In a game fitting of the Champions League final, Barcelona host holders PSG at the Estadi Olimpic Lluis Companys in the clash of the league phase.
Barca started their campaign off with a Marcus Rashford-inspired win at Newcastle and the England international has plenty of history with the French giants.
He has twice scored late winners against them, while his new club famously beat them 6-1 in 2017 to pull off the best comeback in tournament history.
PSG manager Luis Enrique was in charge of Barca but there will be little in way of sentimentality here. His side started their defence of the title in the same manner they won it, with a hammering of an Italian side but their injury list has extended since then.
The Sporting News betting preview covers everything you need to know ahead of this titanic clash.
Barcelona vs. PSG: Form Guide & Predictions
Barcelona are top of La Liga and PSG top the bill as expected after five matches played in Ligue 1 but both also have injury concerns.
PSG's are far greater with numerous key players missing out including Ballon d'Or winner and ex-Barca winger Ousmane Dembele.
That could be the difference here and we think Barca will have too much for the injury-hit Parisians.
The Sporting News Score Prediction for Barcelona vs. PSG
Barcelona 3-1 PSG
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Barcelona vs. PSG Predicted Lineups
Both sides have numerous injuries with PSG set to be without more than half of their starting lineup from last season's final. Here's how we think the two teams will lineup on Wednesday night.
Barcelona predicted lineup vs. PSG
(4-2-3-1, right to left)
Szczesny (GK) — Kounde, Araujo, Cubarsi, Martin — Pedri, De Jong — Lamine Yamal, Olmo, Rashford — Lewandowski.
Injured: Raphinha, Gavi, Eric Garcia, Fermin Lopez
Suspended: None
PSG predicted lineup vs. Barcelona
(4-2-3-1, right to left)
Chevalier (GK) — Hakimi, Zabarnyi, Beraldo, Hernandez — Ruiz, Mayulu — Lee, Barcola, Mendes — Ramos.
Injured: Ousmane Dembele, Marquinhos, Joao Neves, Desire Doue, Khvicha Kvaratskhelia, Vitinha (doubt) Fabian Ruiz (doubt)
Suspended: None
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Barcelona vs. PSG Odds
Barca are favourites to win at 37/40 with BetVictor, while PSG can be found at 14/5 to win with AK Bets. The draw is also best priced at 10/3 with AK Bets.
Our 3-1 prediction is at good odds but here are some other potential scorelines worth looking at.
| Result | Odds | Bet with |
| Barcelona 1-0 | 12/1 | AK Bets |
| PSG 1-0 | 18/1 | Sky Bet |
| Barcelona 2-1 | 8/1 | Bet365 |
| Barcelona 3-1 | 12/1 | Bet365 |
| Draw 1-1 | 17/2 | AK Bets |
Barcelona vs. PSG Team News
As mentioned, both sides are missing several star names. Gavi is out until the new year for Barca while Raphinha's absence means another start for the in-form Marcus Rashford.
PSG could possibly be without seven of the starters from last year's final with Luis Enrique hoping Fabian Ruiz and Vitinha are passed fit at the last minute.
Barcelona vs. PSG Bet Builder Tips
Our bet builder for this one is Barcelona to win with a -1 handicap, over 3.5 goals and Robert Lewandowski to score anytime. That is currently just over 11/1 with Betway.
How to watch Barcelona vs. PSG: Live stream, TV channel
- Date: Wednesday, 28 September
- Venue: Estadi Olimpic Lluis Companys, Barcelona
- Time: 8:00 p.m. (BST)
- TV/Stream: TNT Sports