The 2025/26 La Liga season is off and running, and it is set to be one of the most interesting seasons in recent memory.
Barcelona are the defending champions, having won their 28th title as part of a stunning domestic double in Hansi Flick's first season. On the other side of El Clasico, it was a desperately disappointing season for Real Madrid, who went trophyless despite the goalscoring exploits of Kylian Mbappe.
Elswhere, Atletico Madrid are always a threat as the great disrupters, but could this year see a new team emerge against all the odds?
The Sporting News brings you all the latest odds as the season gets into full swing in Spain.
La Liga predictions 2025/26: Title winners
It's been a summer of change for Real, with Xabi Alonso replacing Carlo Ancelotti in the hotseat, and he has been gifted several new signings amid the departure of Luka Modric. Trent Alexander-Arnold's free transfer arrival is the most eye-catching, but Dean Huijsen and Alvaro Carreras will only further enhance their defence.
Franco Mastantuono has also signed on, with the Argentine the latest young superstar to join the 15-time European champions.
As a result of this and their overall squad depth, they started the season as narrow favourites ahead of Barca, who have added Marcus Rashford to their thrilling frontline, with Lamine Yamal and Raphinha likely to star once again.
But Barca's flying start with seven goals scored and none conceded in their first two games has seen them vault back into favouritism.
Atletico have spent big in a bid to bridge the gap after falling away late last season. Alex Baena is the most high-profile signing, joining from Villarreal, but two draws to open their season have already left them off the pace and they are as a big as 50/1 with Bet365.
The odds reflect the established order in Spanish football, and it would be a shock to rival any in recent football history if someone bar the big three wins the title for the first time since Valencia in 2004.
Here's the best-price currenr La Liga title odds from our selected partners. Click below to bet with each firm.
| Team | Odds* | Bet with |
| Barcelona | 17/20 | Sky Bet |
| Real Madrid | 6/5 | Betway |
| Atletico Madrid | 50/1 | Bet365 |
| Athletic Club | 100/1 | Betway |
| Villarreal | 100/1 | Betway |
*Odds correct at time of publish. Click to bet direct with our selected partners
La Liga predictions 2025/26: Winners without Barcelona and Real Madrid
Barca's title last season made it 12 in the last 21 seasons since Valencia triumphed, with Real claiming seven in that time.
Atletico's stunning successes in 2014 and 2021 broke up the duopoly, so it is hardly a surprise they are odds-on in this market, even after their sub-par start, and very much the favourite to take up their now-regular third place again this season.
Athletic Club did come fourth last season, and kept Nico Williams this summer, so could be worth a look too - and they have started the season strongly.
Here are Bet365's winners' odds without the big two.
| Team | Odds* |
| Atletico Madrid | 1/1 |
| Athletic Club | 3/1 |
| Villarreal | 4/1 |
| Real Betis | 8/1 |
| Real Sociedad | 20/1 |
| Celta Vigo | 50/1 |
*Odds correct at time of publish. Click odds to bet direct with our selected partners
All the latest Real Madrid news | All the latest Barcelona news
La Liga predictions 2025/26: Top four contenders
It's 25 years since Real finished outside the top four and 22 years for Barcelona, while Atletico have been a constant since Diego Simeone's first full season in 2012/13.
As a result, they are all odds-on, and it really is a battle for that fourth Champions League spot, which could become five, as it did last season, dependent on European performances.
Athletic and Villarreal came fourth and fifth last season respectively, only separated by goal difference, and another shootout feels likely this time around.
Here's the latest top four finish odds with Bet365.
| Barcelona | 1/66 |
| Real Madrid | 1/66 |
| Atletico Madrid | 4/7 |
| Athletic Club | 11/10 |
| Villarreal | 11/8 |
| Real Betis | 2/1 |
| Real Sociedad | 8/1 |
| Valencia | 12/1 |
| Celta Vigo | 12/1 |
| Osasuna | 20/1 |
| Getafe | 20/1 |
Click odds to bet direct with our selected partners
Who will win finish in the top four of La Liga this season? Back your pick here with Betfair
La Liga predictions 2025/26: Relegation candidates
Unsurprisingly, the three promoted sides are the favourites to make an immediate return to the second tier.
Elsewhere, Espanyol and Alaves only just stayed up last season, and are tipped for another dogfight at the wrong end of the table.
Here's the latest relegation odds with Bet365.
| Levante | 11/10 |
| Real Oviedo | 11/8 |
| Girona | 11/8 |
| Elche | 2/1 |
| Alaves | 11/4 |
| Espanyol | 3/1 |
| Rayo Vallecano | 3/1 |
| Mallorca | 7/2 |
Click odds to bet direct with our selected partners
La Liga predictions 2025/26: Top goalscorer contenders
Kylian Mbappe might not have won any team trophies in his debut campaign in white, but he did scoop up the Pichichi award with 31 goals, beating off fierce competition from Robert Lewnadowski.
It is likely to be another battle between the two, with one of Atletico pair, Alexander Sorloth or Julian Alvarez, perhaps in with a shout of contention.
Could Lamine Yamal add to his ever-growing legend and become the youngest ever winner of the award?
Here's the latest top goalscorer odds with Sky Bet.
| Kylian Mbappe | 1/2 |
| Robert Lewandowski | 11/4 |
| Raphinha | 8/1 |
| Alexander Sorloth | 11/1 |
| Ante Budimir | 14/1 |
| Julian Alvarez | 14/1 |
| Gonzalo Garcia | 20/1 |
| Lamine Yamal | 20/1 |
Click odds to bet direct with our selected partners
When is the start and end date of the La Liga season 2025/26?
The 2025/26 La Liga season got underway over the space of five days from August 15-19.
There are 38 rounds of games, either side of a two-week winter break from December 21 to January 4.
The season is scheduled to finish on Sunday May 24, 2026.
Bet 5p to get £30 in free bets with Sky Bet for the 2025/26 season
How to watch the La Liga 2025/26 season in the UK
The 2025/26 La Liga season will be available for UK viewers on a range of platforms, with games being shown on Premier Sports and Disney +, as well as on the Bet365 website and app.
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