The Rams and 49ers will face off in a pivotal Week 5 showdown Thursday night.
The winner of this game will take sole possession at the top of the NFC West, as both teams enter the game 3-1.
Los Angeles is coming off a big win in Week 4 thanks to an 88-yard touchdown strike from Matthew Stafford to Tutu Atwell late in the game. San Francisco couldn't muster a fourth-quarter comeback against Jacksonville and lost its first game of the 2025 season.
The Rams also enter the game very healthy; the team will have its full complement of players, including Stafford, receivers Davante Adams and Puka Nacua, running back Kyren Williams and their entire defensive line.
The 49ers, on the other hand, are very injured. Quarterback Brock Purdy and receiver Ricky Pearsall are both questionable with injuries; receiver Jauan Jennings is still hurt; and tight end George Kittle is still on injured reserve. A lot will be riding on star running back Christian McCaffrey in this one.
Here is everything you need to know about Rams vs. 49ers, including TV and streaming options for Thursday's game.
What channel is Rams vs. 49ers on?
- TV channel: N/A
- Live stream: Prime Video
The Rams vs. 49ers game will air exclusively on Prime Video.
Al Michaels (play-by-play) and Kirk Herbstreit (analyst) will be on the call with Kaylee Hartung reporting from the sidelines.
Rams vs. 49ers start time
- Date: Thursday, Oct. 2
- Time: 8:15 p.m. ET
Rams vs. 49ers will kick off at 8:15 p.m. ET on Thursday, Oct. 2. The game will be played at SoFi Stadium in Los Angeles.
Rams vs. 49ers radio station
- Radio station: SiriusXM channels 225 (Rams broadcast), 226 (49ers broadcast)
You can listen to Rams vs. 49ers live on SiriusXM. Coverage will be available on channels 225 (Rams broadcast) and 226 (49ers broadcast).
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Rams 2025 schedule
Here's the full 2025 schedule for Los Angeles.
| Date | Game | Time | TV/Live stream |
|---|---|---|---|
| Sept. 7 | Rams 14, Texans 9 | — | — |
| Sept. 14 | Rams 33, Titans 19 | — | — |
| Sept. 21 | Eagles 33, Rams 26 | — | — |
| Sept. 28 | Rams 27, Colts 20 | — | — |
| Oct. 2 | vs. 49ers | 8:15 p.m. | Prime Video |
| Oct. 12 | at Ravens | 1 p.m. | FOX |
| Oct. 19 | vs. Jaguars | 9:30 a.m. | NFL Network, NFL+ |
| Nov. 2 | vs. Saints | 4:05 p.m. | FOX |
| Nov. 9 | at 49ers | 4:25 p.m. | FOX |
| Nov. 16 | vs. Seahawks | 4:05 p.m. | FOX |
| Nov. 23 | vs. Buccaneers | 8:20 p.m. | NBC |
| Nov. 30 | at Panthers | 1 p.m. | FOX |
| Dec. 7 | at Cardinals | 4:25 p.m. | FOX |
| Dec. 14 | vs. Lions | 4:25 p.m. | FOX |
| Dec. 18 | at Seahawks | 8:15 p.m. | Prime Video |
| Dec. 29 | at Falcons | 8:15 p.m. | TBD |
| TBD | vs. Cardinals | TBD | TBD |
49ers 2025 schedule
Here's the full 2025 schedule for San Francisco.
| Date | Game | Time | TV/Live stream |
|---|---|---|---|
| Sept. 7 | 49ers 17, Seahawks 13 | — | — |
| Sept. 14 | 49ers 26, Saints 21 | — | — |
| Sept. 21 | 49ers 16, Cardinals 15 | — | — |
| Sept. 28 | Jaguars 26, 49ers 21 | — | — |
| Oct. 2 | at Rams | 8:15 p.m. | Prime Video |
| Oct. 12 | at Buccaneers | 1 p.m. | CBS |
| Oct. 19 | vs. Falcons | 8:20 p.m. | NBC |
| Oct. 26 | at Texans | 1 p.m. | FOX |
| Nov. 2 | at Giants | 1 p.m. | CBS |
| Nov. 9 | vs. Rams | 4:25 p.m. | FOX |
| Nov. 16 | at Cardinals | 4:05 p.m. | FOX |
| Nov. 24 | vs. Panthers | 8:15 p.m. | — |
| Nov. 30 | at Browns | 1 p.m. | CBS |
| Dec. 14 | vs. Titans | 4:25 p.m. | FOX |
| Dec. 22 | at Colts | 8:15 p.m. | — |
| Dec. 28 | vs. Bears | 8:20 p.m. | NBC |
| TBD | vs. Seahawks | TBD | — |
NFL Week 5 schedule
Thursday, October 2, 2025
| Game | Time | TV/Live stream |
|---|---|---|
| San Francisco at Los Angeles | 8:15 p.m. | Prime Video |
Sunday, October 5, 2025
| Game | Time | TV/Live stream |
|---|---|---|
| Minnesota at Cleveland | 9:30 a.m. | NFL Net / NFL+ |
| Las Vegas at Indianapolis | 1 p.m. | FOX, Fubo |
| New York at New Orleans | 1 p.m. | CBS |
| Dallas at New York | 1 p.m. | FOX |
| Denver at Philadelphia | 1 p.m. | CBS |
| Miami at Carolina | 1 p.m. | FOX |
| Houston at Baltimore | 1 p.m. | CBS |
| Tennessee at Arizona | 4:05 p.m. | CBS |
| Tampa Bay at Seattle | 4:05 p.m. | CBS |
| Detroit at Cincinnati | 4:25 p.m. | FOX |
| Washington at Los Angeles | 4:25 p.m. | FOX |
| New England at Buffalo | 8:20 p.m. | NBC |
Monday, October 6, 2025
| Game | Time | TV/Live stream |
|---|---|---|
| Kansas City at Jacksonville | 8:15 p.m. | ABC, ESPN |