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NFL Week 6 betting odds, lines, point spreads and over/under totals for every 2024 football game

Sloan Piva

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Over a quarter of the 2024 NFL regular season has passed, and it has been a wild ride for bettors and fans alike. We've seen surprise upsets and stunning comebacks in each of the first five weeks, but the AllSportsPeople best bets, top props, and DFS lineups have managed to succeed through it all. 

The most important part of betting is not luck — it's knowledge. Checking this column early and often each week helps you identify value wagers, recognize betting trends, and understand how oddsmakers think.

Then, when the betting public influences shifts in the odds throughout the week, you start realizing the angles worth attacking. Paired with SN's best bets, primetime game predictions, and weekly pick'em columns, you'll have all the resources you need to be a confident and informed bettor.

Long story short, this column will host the moneyline, spread, and over/under odds for every matchup on the Week 6 schedule. Let's dive in, then break down the early values, top storylines, and props to target from the weekend's games. 

NFL Week 6 odds: Lines, spreads, over/under totals

All odds courtesy of BetMGM. 

Day/time (ET)	Game	ML	ATS	O/U
Thu., 10/10 8:15 p.m.	49ers @ Seahawks	SF -160 SEA +135	SF -3 (-115) SEA +3 (-105)	O 47.5 (-110) U 47.5 (-110)
Sun., 10/13 9:30 a.m.	Jaguars @ Bears (UK)	CHI -135 JAX +110	CHI -2.5 (-105) JAX +2.5 (-115)	O 43 (-105) U 43 (-115)
Sun., 10/13 1:00 p.m.	Cardinals @ Packers	GB -250 ARI +210	GB -5 (-110) ARI +5 (-110)	O 49.5 (-110) U 49.5 (-110)
Sun., 10/13 1:00 p.m.	Browns @ Eagles	PHI -350 CLE +250	PHI -8.5 (-110) CLE +8.5 (-110)	O 44.5 (-110) U 44.5 (-110)
Sun., 10/13 1:00 p.m.	Texans @ Patriots	HOU -350 NE +280	HOU -7 (-110) NE +7 (-110)	O 37.5 (-110) U 37.5 (-110)
Sun., 10/13 1:00 p.m.	Colts @ Titans	TEN -110 IND -110	TEN -1.5 (+100) IND +1.5 (-120)	O 42.5 (-110) U 42.5 (-110)
Sun., 10/13 1:00 p.m.	Buccaneers @ Saints	NO -150 TB +130	NO -2.5 (-120) TB +2.5 (+100)	O 45.5 (-110) U 45.5 (-110)
Sun., 10/13 1:00 p.m.	Commanders @ Ravens	BAL -300 WAS +240	BAL -6.5 (-110) WAS +6.5 (-110)	O 51.5 (-110) U 51.5 (-110)
Sun., 10/13 4:05 p.m.	Chargers @ Broncos	LAC -150 DEN +125	LAC -2.5 (-115) DEN +2.5 (-105)	O 36.5 (-110) U 36.5 (-110)
Sun., 10/13 4:25 p.m.	Falcons @ Panthers	ATL -225 CAR +185	ATL -5.5 (-110) CAR +5.5 (-110)	O 48.5 (-105) U 48.5 (-115)
Sun., 10/13 8:20 p.m.	Bengals @ Giants	CIN -200 NYG +165	CIN -3.5 (-110) NYG +3.5 (-110)	O 48.5 (-110) U 48.5 (-110)
Mon., 10/14 8:15 p.m.	Bills @ Jets	BUF -145 NYJ +120	BUF -2.5 (-115) NYJ +2.5 (-105)	O 41.5 (-110) U 41.5 (-110)

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NFL Week 6: Odds, betting storylines to watch

This week features plenty of close matches, including the Thursday Night Football opener between the division-rival 49ers and Seahawks (SF -3). Tampa Bay and Atlanta mounted a similar divisional battle last Thursday, and the offenses of both San Francisco and Seattle have started hot this season. Still, the opening total of 47.5 seems a bit high given these teams both have strong defenses. 

As for the Bears and Jaguars at Tottenham Hotspur Stadium in the UK (CHI -2.5), the early OVER of 43 seems very alluring. Chicago and Jacksonville both got wins in Week 5, while finishing with respective totals of 36 and 37 points in the process. 

Coming off a bye week, the Eagles (-9) at home against the stumbling, bumbling Browns seems like the heavy favorite of the week. Cleveland can't seem to get anything going offensively, so a potentially back-to-healthy Philly squad could be big trouble for Deshaun Watson and company. The Texans (-7) in New England seems intriguing, too.

The shootout of the week could be reigning MVP Lamar Jackson and the Ravens against Rookie of the Year frontrunner Jayden Daniels and the Commanders (BAL -6.5, O/U 51.5). The defensive battle of the Sunday slate could be Broncos vs. Chargers in Denver (LAC -2.5, O/U 36.5). 

A player prop we can't wait to drop: Mike Evans' receiving total. The man always gets up for Bucs-Saints games, as he and cornerback Marshon Lattimore have one of the better rivalries in today's NFL. Our money's on Evans to win the battle, as the future Hall-of-Famer is coming off a two-touchdown game and a mini-bye following the TNF game. 

Be sure to check back often throughout the week as the action shifts and the lines change. And don't miss our best bets and top props, dropping Monday and updated daily until the weekend's games!