There are only a few Monday Night Football matchups remaining in the 2025 season, and the Week 16 edition is set to feature two playoff contenders in opposing conferences.
The Indianapolis Colts will be hosting the San Francisco 49ers on Monday night, with each squad holding onto playoff hopes despite varying circumstances. Injuries have been a theme for each; for San Francisco, virtually every big name on its veteran roster has missed some kind of time in 2025.
It's Indianapolis' quarterback situation that will be in the spotlight though, as the 44-year-old Philip Rivers trots back out for his second start after making a shocking return to the NFL in Week 15 as a fill-in starter after Daniel Jones' injury.
After nearly taking down the Seahawks last week, Rivers will be seeking his first win in five years against the 49ers. Meanwhile, Kyle Shanahan's unit will be eyeing a win to come closer to locking in a playoff spot.
Here's everything you need to know about watching Monday Night Football, including TV and streaming information for 49ers vs. Colts.
Who plays on Monday Night Football tonight?
- Matchup: 49ers vs. Colts
- Location: Lucas Oil Stadium in Indianapolis, Indiana
The Colts host the 49ers on Monday Night Football in Week 16, with the game set to be played at Lucas Oil Stadium in Indianapolis, Indiana.
What time is the NFL game on tonight?
- Date: Monday, Dec. 22
- Time: 8:15 p.m. ET
Kickoff for Monday Night Football is scheduled for 8:15 p.m. ET on Monday, Dec. 22.
What channel is Monday Night Football on tonight?
Monday Night Football will be simulcast live on both ABC and ESPN with Joe Buck (play-by-play) in the booth alongside Troy Aikman (analyst).
The game will stream live on Fubo, which offers a free trial, as well as via the brand-new ESPN app.
Now you can watch ESPN without cable. Stream live NBA, NFL, MLB, NHL, college sports, plus SportsCenter, First Take, and all your favorite ESPN shows—anytime, anywhere—only in the new ESPN app.
Monday Night Football radio station
- Radio channel: SiriusXM
Fans can listen to Monday Night Football live with SiriusXM on channel 88, NFL Radio, for the national broadcast.
Team-specific calls are available on channel 226 (49ers broadcast) and 225 (Colts broadcast).
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