TL;DR
- Christian McCaffrey traded to 49ers from Panthers for draft picks in October 2022.
- McCaffrey faces his former team, the Panthers, in a crucial Week 12 "Monday Night Football" game.
- Both 49ers and Panthers are in playoff contention, with running backs as a focal point.
- The game's outcome will significantly impact NFC wild card standings and playoff picture.
JUMP TO:
On October 20, 2022, the Carolina Panthers traded All-Pro running back Christian McCaffrey to the San Francisco 49ers for four draft selections. McCaffrey is now scheduled to play against his old team more than three years later.
Carolina will journey to play the 49ers on "Monday Night Football" to conclude Week 12, in a matchup that will subtly carry considerable NFC wild card weight. The Panthers are experiencing their best season in quite some time, arriving at Week 12 with a 6-5 record and still possessing a shot at the NFC South title. The 49ers, on the other hand, have battled through injuries, yet remain firmly in the playoff contention.
Running backs will be the focal point of Monday's contest. Not only is McCaffrey's initial game against the Panthers following the 2022 major trade a significant narrative, but he also stands among the NFL's top performers in receptions (74) and total touchdowns (11). On the opposing side, Rico Dowdle has spearheaded the Panthers' offensive revival in 2025, accumulating more than 800 rushing yards across 11 games.
The victor of Monday night's 49ers-Panthers matchup will have a greater impact on the NFC playoff standings. Will Bryce Young's Panthers secure a road victory, or will Brock Purdy's 49ers maintain their pace in the NFC West?
AllSportsPeople is providing real-time updates and key moments as the 49ers face the Panthers on Monday night, concluding Week 12 of the NFL schedule. Stay tuned for the game's developments below.
WATCH: Stream 49ers vs. Panthers via the new ESPN app
49ers vs. Panthers score
NFL HQ: Live NFL scores | Updated NFL standings | Full NFL schedule
49ers and Panthers face off in live updates and highlights from Their Week 12 'Monday Night Football' matchup.
5:21 p.m.: Christian McCaffrey is on-site ahead of the first matchup vs. His former team.
CMC means business 👔@LEVIS | #FTTB pic.twitter.com/czwF0MwyJQ
— San Francisco 49ers (@49ers) November 24, 2025
McCaffrey established new Panthers franchise benchmarks for total scrimmage yards in a season, receptions in a season, and career receptions and receiving yards. He also achieved NFL single-season milestones, becoming the third player in league history to achieve a 1,000-yard rushing and 1,000-yard receiving season (in 2019), setting the NFL record for receptions by a running back with 116 in 2019, and becoming the quickest to reach 3,000 rushing and receiving yards combined, accomplishing this in 57 games.
5:19 p.m.: The Panthers are breaking out a new uniform combination for tonight's primetime matchup.
New fit unlocked 🔓 pic.twitter.com/Z3B1BNmDRy
— Carolina Panthers (@Panthers) November 24, 2025
Carolina will wear its alternate black helmets and black pants with its white road uniforms.
MORE NFL WEEK 12:
- Why Chiefs remain outside playoff picture even after beating Colts in OT
- How Steelers' loss, Ravens' win flips leaderboard in AFC North
- Lions, Bears, Packers all picks up wins to maintain pace in NFC North
- Jaxon Smith-Njigba breaks Seahawks' single-season receiving record in just 11 games
- Amon-Ra St. Browns trolls Giants with Victor Cruz salsa celebration
How to view the 49ers versus Panthers game
49ers vs. Panthers start time
- Date: Monday, Nov. 24
- Start time: 8:15 p.m. ET
The 49ers and Panthers will kick off Week 12's edition of "Monday Night Football" at 8:15 p.m. ET.
The game will be played at Levi's Stadium in Santa Clara, California.
MORE: Rams, Cowboys rise in Week 12 NFL power rankings
You can watch the 49ers vs. Panthers game on FOX.
The "Monday Night Football" matchup between San Francisco and Carolina will air nationally on ESPN.
Fans have the option to stream "Monday Night Football" via the ESPN app. Additionally, the game is available for live streaming on Fubo, a service that includes ABC, ESPN, and ESPN2 in its programming and is presently providing a complimentary trial period.
49ers 2025 schedule
Here's the rest of San Francisco's 2025 schedule.
| Date | Opponent | Time (EST) |
| Sun., Nov 30 | at Browns | 1 p.m. |
| Sun., Dec. 14 | vs. Titans | 4:25 p.m. |
| Mon., Dec. 22 | at Colts | 8:15 p.m. |
| Sun., Dec. 28 | vs. Bears | 8:20 p.m. |
| TBD | vs. Seahawks | TBD |
Panthers 2025 schedule
Here's the rest of Carolina's 2025 schedule.
| Date | Opponent | Time (EST) |
| Sun., Nov 30 | vs. Rams | 1 p.m. |
| Sun., Dec. 14 | at Saints | 4:25 p.m. |
| Sun., Dec. 21 | vs. Buccaneers | 1 p.m. |
| TBD | vs. Seahawks | TBD |
| TBD | at Buccaneers | TBD |