Two of the most exciting running backs are set to face each other in Santa Clara on Monday Night Football.
Many didn't have Rico Dowdle being in the same sentence as Christian McCaffrey on their bingo card. However, Dowdle and the Carolina Panthers have won as the underdog plenty of times this season, but the San Francisco 49ers are finally fully healthy.
Bryce Young has made a statement this season about all the doubt surrounding him. Young has won six of his last eight starts and is beginning to click with rookie receiver Tetairoa McMillan.
Meanwhile, the 49ers got Brock Purdy healthy, and the connection with tight end George Kittle is alive and thriving. Also getting his first in-game action since Week 4 was receiver Ricky Pearsall.
Here's everything you need to know about watching 49ers vs. Panthers in Week 12, including TV, streaming, and radio coverage information.
What channel is 49ers vs. Panthers on today?
49ers vs. Panthers will be on "Monday Night Football" in Week 12, which will air nationally on both ABC and ESPN. Joe Buck (play-by-play) will be in the booth alongside Troy Aikman (analyst).
The game will stream live on the ESPN app, along with Fubo, which offers a free trial.
Now you can watch ESPN without cable. Stream live NBA, NFL, MLB, NHL, college sports, plus SportsCenter, First Take, and all your favorite ESPN shows—anytime, anywhere—only in the new ESPN app.
What time is 49ers vs. Panthers today?
- Date: Monday, Nov. 24
- Time: 8:15 p.m. ET
49ers vs Panthers on "Monday Night Football" will be at 8:15 p.m. ET on Monday, Nov. 24.
The game will be played at Levi's Stadium in Santa Clara, California.
49ers vs. Panthers radio coverage
- Radio: SiriusXM
Fans can listen to "Monday Night Football" between San Francisco and Carolina live with SiriusXM on channel 225 (49ers broadcast) or channel 226 (Panthers broadcast).
New subscribers get their first month of SiriusXM for free. Listen to every NFL game live, plus college football, MLB, NBA, NHL, NASCAR and more. Stay updated with all the news and analysis from SiriusXM NFL Radio and other sport-specific channels.
49ers schedule 2025
Here's a look at San Francisco's next five games:
| Date | Game | Time (ET) |
| Sun, Nov. 30 | at Browns | 1:00 p.m. |
| Sun, Dec. 14 | vs. Titans | 4:25 p.m. |
| Mon, Dec. 22 | at Colts | 8:15 p.m. |
| Sun, Dec. 28 | vs. Bears | 8:20 p.m. |
| TBD | vs. Seahawks | TBD |
Panthers schedule 2025
Here's a look at Carolina's next five games:
| Date | Game | Time (ET) |
| Sun, Nov. 30 | vs. Rams | 1:00 p.m. |
| Sun, Dec. 14 | at Saints | 4:25 p.m. |
| Sun, Dec. 21 | vs. Buccaneers | 1:00 p.m. |
| TBD | vs. Seahawks | TBD |
| TBD | at Buccaneers | TBD |