Indiana vs. Oregon predictions: Expert picks and odds for 2025 CFP semifinal at Peach Bowl

Bill Bender

Indiana vs. Oregon predictions: Expert picks and odds for 2025 CFP semifinal at Peach Bowl image

No. 1 Indiana will meet No. 5 Oregon in a College Football Playoff semifinal at the Chick-fil-A Peach Bowl on Friday, Jan. 9. 

Kickoff is scheduled for 7:30 p.m. The game will be televised on ESPN. This is an all-Big Ten matchup. 

Indiana (14-0) dominated No. 9 Alabama 38-3 in the Rose Bowl Game presented by Prudential. The Hoosiers are the lone unbeaten team remaining in the FBS, and second-year coach Curt Cignetti has the Hoosiers one victory away from playing for a national championship. Heisman Trophy winner Fernando Mendoza finished 14 of 16 for 192 passing yards and three TDs in the blowout against the Crimson Tide.

Oregon (13-1) shut out No. 5 Texas Tech 23-0 in the Capital One Orange Bowl. Dan Lanning is making his first CFP semifinal appearance as the Ducks' coach, and the combination of efficient play from Dante Moore and a defense that forced four turnovers against the Red Raiders has been tough to beat. The Ducks made the BCS championship game in 2011 and CFP championship game in 2015.

Indiana beat Oregon 30-20 at Autzen Stadium on Oct. 11. Will the Hoosiers win the rematch at a neutral site?

MORE: Indiana continues to smash narratives under Curt Cignetti

Here is an early look at the betting odds and our pick for the winner of the Fiesta Bowl (Odds courtesy of Caesars):

College Football Playoff semifinal odds

  • Spread: Indiana -4.5
  • Over/under: 48
  • Moneyline: Indiana -200, Oregon +170 

The Hoosiers were a seven-point underdog in the first meeting. That will be the case in the rematch. Expect the Hoosiers to be a favorite by less than a touchdown for the first time all season.

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College Football Playoff semifinal pick, prediction

Indiana-Oregon II has all the makings of an instant classic, and it starts with the quarterback matchup. Mendoza threw a fourth-quarter pick six to freshman Brandon Finney Jr. In the last meeting – but the Heisman winner bounced back to lead the game-winning drive. According to PFF, Mendoza was 5 of 11 for 73 yards on passes of 10 yards or more. Elijah Sarratt, Omar Cooper Jr. And Charlie Becker all caught TD passes in the Rose Bowl. Finney had two interceptions and fumble recovery against Texas Tech. Still, Indiana might get the ball out of Mendoza's hands early in this matchup. 

The same could be said for Oregon quarterback Dante Moore Jr, who was 4 of 9 for 89 yards a TD and an interception in the same situation. Malik Benson had a 44-yard TD catch in the first meeting – the longest catch on either side. Indiana had six sacks in the first meeting. Oregon had one. Will those trends stay the same? Moore should be better the second time around against the Hoosiers. 

Both teams rely on a physical running game – and Indiana remains in high gear with the tag team of Roman Hemby and Kaelon Black. They combined for 26 carries for 101 yards in the first matchup, and Hemby had two TDs. Oregon running backs Jordon Davison and Noah Whittington combined for 13 carries for 86 yards. Lanning will need to stay more patient in the running game. Oregon had one more turnover in that matchup – and Indiana feasts on mistakes. 

Which disruptive defensive player is a difference-maker? Indiana linebacker Aiden Fisher and Oregon linebacker Bryce Boettcher combined for 24 tackles in the first meeting. Oregon safety Dillon Thieneman and Indiana cornerback D'Angelo Ponds are game-changers in the secondary. The Hoosiers are a little better on third down and creating tackles for loss – so that is another in-game trend to watch. 

Both defenses are playing at an elite level right now – which will put more pressure on Mendoza and Moore in a matchup that is sure to draw more than enough interest for the 2026 NFL Draft. These could be the first two quarterbacks selected in that draft. Oregon will have to be better on third down (3 of 14), but we know Lanning will not shy away from going for it on a key fourth-down situation. Will Cignetti do the same?

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Rematches are always tricky, and the Ducks' defense has been solid since that first loss to the Hoosiers. We had Indiana in our initial CFP bracket, and the Hoosiers have given us no reason to change that pick. Mendoza delivers in the clutch again in the fourth quarter, and Indiana advances to the CFP championship game. 

College Football Playoff semifinal score prediction

Indiana 28, Oregon 21

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