A marquee Big Ten conference battle awaits in Week 13 as the USC Trojans travel north to face the Oregon Ducks at Autzen Stadium. This Saturday afternoon clash between two former Pac-12 powerhouses carries significant College Football Playoff implications, with Oregon looking to solidify their position in the Big Ten race while USC fights to keep their postseason dreams alive.
USC vs Oregon Betting Predictions and Picks
Both programs bring explosive offenses into this matchup. USC enters averaging an impressive 488.9 total yards and 37.6 points per game, showcasing the high-octane attack that Lincoln Riley has built in Los Angeles. The Trojans are particularly lethal in scoring situations, converting a staggering 94.0% of their red zone attempts. Oregon matches that firepower under Dan Lanning, putting up 38.8 points per game on 475.4 total yards while maintaining excellent ball security with a +4 turnover differential.
The stakes couldn't be higher for this late-season showdown. Oregon sits comfortably in playoff position and can take a major step toward the Big Ten championship game with a victory. For USC, this represents a must-win scenario to stay in the playoff conversation, making for compelling television when these offensive juggernauts collide.
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USC vs Oregon Betting Odds
- Moneyline: Oregon -391 | USC +304
- Spread: Oregon -10 (-111) | USC +10 (-109)
- Total: Over/Under 59.5 (Over -107 / Under -114)
Betting odds courtesy of consensus odds.
The Ducks enter as heavy home favorites, with the -391 moneyline reflecting their playoff positioning and home-field advantage. USC comes in as substantial +304 underdogs, though the 10-point spread has tightened from an opening line of Oregon -14.5, suggesting some sharp action on the Trojans. The total has climbed significantly from 55.5 to 59.5, indicating the betting market expects a high-scoring affair between these offensive powerhouses.
Game Information:
- Date: Saturday, November 22, 2025
- Kickoff: 3:30 p.m. EST
- Location: Autzen Stadium, Eugene, OR
- TV: CBS
Offensive Firepower Takes Center Stage in Key Statistical Matchup
This showdown features two of the Big Ten's most potent offensive units, with each team bringing distinct strengths that should create fascinating tactical battles. USC holds a slight edge in total offense at 488.9 yards per game compared to Oregon's 475.4, while the scoring is virtually even with the Ducks at 38.8 points per game and the Trojans at 37.6.
The contrasting offensive philosophies set up intriguing matchups across the field. USC relies heavily on their aerial attack, generating 298.1 passing yards per game through Lincoln Riley's system, while Oregon deploys a more balanced approach with 241.8 passing yards complemented by a powerful ground game that churns out 233.6 rushing yards per contest.
Execution in crucial moments separates both teams from the pack. The Trojans have been masterful in the red zone, converting an elite 94.0% of their trips into points while maintaining a solid 51.7% third-down conversion rate. Oregon nearly matches that efficiency, scoring on 87.8% of red zone attempts and converting 49.2% on third downs.
The defensive battle will center on USC's pass rush, which has generated 24.0 sacks this season, trying to disrupt Oregon's rhythm, while the Ducks' defense (17.0 sacks) must find ways to pressure USC's passing attack. Both teams enter with positive turnover margins, suggesting ball security won't be a major factor unless the pressure creates uncharacteristic mistakes.
USC vs Oregon Expert Prediction and Best Bet
While Oregon deserves respect as the home favorite at the intimidating Autzen Stadium, the most compelling angle in this game centers on the explosive offensive potential both teams bring to the table.
The numbers strongly support a high-scoring affair. These two teams combine to average over 76 points per game, well above the 59.5 total. More importantly, both offenses excel at finishing drives - USC's 94.0% red zone conversion rate paired with Oregon's 87.8% efficiency suggests that sustained drives will consistently result in points rather than field goals or turnovers.
Given the playoff implications and both teams' ability to move the ball effectively, expect both offensive coordinators to be aggressive throughout the contest. The Ducks will look to establish their ground game early while USC will test Oregon's secondary with their dynamic passing attack.
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Best Bet: Over 59.5 (-107)
The statistical evidence points toward a shootout, and with both teams needing offensive production to achieve their respective goals, this total feels achievable even if one team pulls away late.