The Seattle Seahawks and Carolina Panthers clash in a pivotal Week 17 showdown at Bank of America Stadium, with massive playoff implications hanging in the balance. Seattle enters as the NFC's top seed, positioning themselves for a potential first-round bye and home-field advantage throughout the playoffs. Meanwhile, the Panthers are fighting to end an eight-year playoff drought and capture their first postseason berth since 2017.
Seahawks vs Panthers Week 17 Picks
This matchup presents a fascinating contrast between Seattle's explosive offense averaging 29.1 points per game and Carolina's steady, disciplined approach under head coach Dave Canales. The Seahawks are riding high after a dramatic comeback victory over the Rams, with their home crowd creating playoff-like intensity that's now carrying over to the road.
The Panthers counter with their own reinvigorated fanbase, who turned Bank of America Stadium into a raucous environment in their recent home win, complete with black towels and crowd noise that rattled opponents into penalties.
Key individual storylines include the battle in the trenches, where Seattle's ferocious pass rush, featuring Leonard Williams, has accumulated 42 sacks this season. They'll test a Panthers offensive line anchored by veteran Taylor Moton. On the flip side, Carolina's defensive standout Derrick Brown will look to disrupt a Seahawks attack featuring elite playmaker Cooper Kupp.
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Seahawks vs Panthers Betting Odds
Date: Sunday, Dec. 28, 2025
Time: 1:00 PM EST
Venue: Bank of America Stadium — Charlotte, NC
- Moneyline: Seattle Seahawks (-375) | Carolina Panthers (+295)
- Spread: Seattle Seahawks -7 (-118) | Carolina Panthers +7 (-102)
- Total: Over/Under 42.5 (O -110 / U -110)
Betting odds courtesy DraftKings.
The Seahawks enter as significant road favorites with the -375 moneyline reflecting strong oddsmaker confidence in their victory. Carolina sits as considerable home underdogs at +295, while the point spread is set at a full touchdown in Seattle's favor. The 42.5-point total suggests expectations for a moderately scoring affair.
How the Seahawks and Panthers Stack Up Statistically
The offensive disparity between these teams is immediately apparent when examining the numbers. Seattle brings a high-powered attack generating 354.9 yards and 29.1 points per game, with an impressive 58.0% red-zone conversion rate. This contrasts sharply with Carolina's more methodical approach of 306.7 yards and 19 points per game, converting 51.2% of their red-zone opportunities.
The most significant mismatch lies in pass rush effectiveness. The Seahawks' defense has terrorized opposing quarterbacks with 42 sacks this season, while the Panthers have managed a more modest 25 sacks. This battle in the trenches will likely determine the game's flow, especially considering Carolina holds a slight edge on third down efficiency at 38.7% compared to Seattle's 37.9%.
Recent momentum tells an interesting story. Seattle exploded for 38 points in their last outing, showcasing their offensive ceiling, while the Panthers secured their recent win through discipline, committing zero turnovers. However, Seattle's explosive style has led to more mistakes with 26 turnovers and a -5 turnover differential, compared to Carolina's 18 turnovers and -2 differential. The game could hinge on whether Seattle's high-octane offense can overcome its turnover tendencies against a disciplined Panthers squad.
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Seahawks vs Panthers Expert Pick and Prediction
While Carolina enjoys home-field advantage and an improving defense, the statistical gap between these teams is too significant to overlook. Seattle's offense is firing on all cylinders, and their primary strength—a relentless pass rush—directly attacks Carolina's biggest vulnerability in pass protection.
The Panthers' path to victory requires a mistake-free performance, which becomes increasingly difficult against a Seahawks team that excels at creating chaos. Unless Carolina's defense can completely neutralize a unit averaging over 29 points per game, Seattle possesses too many weapons to maintain a comfortable lead throughout.
Best Bet: Seattle Seahawks -7 (-118)
The Seahawks' 29.1 points per game represents a full 10-point advantage over Carolina's 19.0 average. Combined with their 42.0 sacks creating consistent pressure, this two-sided dominance should be sufficient for Seattle to win by more than a touchdown on the road.
Best Prop: Bryce Young Over 0.5 Interceptions Thrown (-148)
This play capitalizes on the game's biggest mismatch. Seattle's pass rush has been a nightmare for opposing quarterbacks all season, and facing a likely negative game script will force Young into uncomfortable throwing situations under duress. This creates a high-probability scenario for at least one turnover.