The Missouri Tigers head to Norman for a pivotal Southeastern Conference battle against the Oklahoma Sooners in Week 13, with both teams fighting for different but equally important goals. Oklahoma has surged into the top 10 in recent power rankings following strong performances, positioning themselves as legitimate College Football Playoff contenders under head coach Brent Venables. The Sooners need to finish strong against Missouri to solidify their postseason chances in this high-stakes SEC matchup.
Missouri vs Oklahoma Betting Picks and Predictions
Meanwhile, Missouri is looking to build momentum after snapping a recent skid. Coach Eliah Drinkwitz has framed this as a redemption opportunity for the Tigers, emphasizing the importance of regaining their offensive rhythm in a road test that could significantly impact their late-season SEC positioning and bowl eligibility. This classic border-state rivalry renewed in the SEC will be showcased on a prominent network slot, amplifying the stakes for both programs.
The matchup features contrasting offensive philosophies that should make for compelling viewing at Gaylord Family Oklahoma Memorial Stadium.
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Missouri vs Oklahoma Betting Odds
• Moneyline: Oklahoma Sooners (-266), Missouri Tigers (+215)
• Spread: Oklahoma Sooners -6.5 (-114), Missouri Tigers +6.5 (-106)
• Total (Over/Under): 42.5 (Over -109 / Under -111)
Betting odds courtesy of consensus odds.
Oklahoma enters as the clear home favorite at -266 on the moneyline with a 6.5-point spread, while Missouri sits as the road underdog at +215 to pull off the upset. The most notable movement has been in the game total, which has dropped dramatically from its opening line of 54.5 points down to 42.5, signaling oddsmakers now expect a much more defensive battle than initially projected.
Game Information:
• Kickoff: Friday, November 22, 2025, at 12:00 p.m. EST
• Location: Gaylord Family Oklahoma Memorial Stadium, Norman, OK
• Network: SEC Network
Statistical Breakdown: Contrasting Offensive Philosophies
This game presents a fascinating clash between Missouri's high-octane offense and Oklahoma's methodical, efficient attack. The Tigers bring a dynamic offensive machine that averages an impressive 34.5 points and 450.4 total yards per game. Their identity centers around a powerful rushing attack generating 241.7 yards per contest, complemented by 2087 passing yards. Most impressively, Missouri converts an exceptional 49.3% of their third-down attempts, showcasing their ability to sustain drives.
Oklahoma operates differently, averaging a solid but more conservative 27.7 points on 357.5 total yards per game. The Sooners lean slightly more toward the passing game with 226.8 yards through the air compared to 130.7 on the ground. However, their defining characteristic is clinical red zone execution - Oklahoma has converted a perfect 100.0% of their red zone opportunities this season.
The key battle will likely occur in the trenches. Oklahoma's defense has been relentless, accumulating 37.0 sacks this season and creating consistent pressure on opposing quarterbacks. This presents the ultimate test for Missouri's high-powered offense, which has otherwise been difficult to contain. The Tigers' defense has also shown it can disrupt, recording 29.0 sacks of their own this year.
Running back performances will be crucial, with Oklahoma's ground game looking to build on recent success while Missouri seeks to bounce back after being held to just one touchdown in their last outing.
Injury Report: Both Teams Enter Healthy
Both the Missouri Tigers and Oklahoma Sooners appear to be heading into this critical conference matchup in excellent health. Neither team has reported significant, game-altering injuries to key players on either side of the ball as of the latest reports.
This development is massive for a game where the total has dropped to just 42.5 points, meaning every possession will be magnified. Missouri's potent rushing attack that averages 241.7 yards per game will be at full strength to challenge Oklahoma's pass-rushing unit responsible for 37.0 sacks. Similarly, the Sooners' offense will have all weapons available as they look to maintain their perfect red zone efficiency.
The absence of major injuries sets up a true best-on-best clash where neither team will have excuses.
Game Prediction: Defense Takes Center Stage in Norman
This matchup boils down to a classic battle between Missouri's explosive offense and Oklahoma's disruptive defense, but the trenches will ultimately decide the outcome. While the Tigers have been impressive offensively all season, the Sooners' defensive front presents their toughest challenge yet.
Oklahoma's defense has been a wrecking crew with 37.0 sacks, and that relentless pressure should test Missouri's rhythm-based offensive approach. The Tigers rely on sustaining drives and their exceptional 49.3% third-down conversion rate, but consistent pass rush can disrupt timing and force uncomfortable situations. Meanwhile, Oklahoma's methodical 27.7 points per game suggests they're built for grinding out wins rather than shootouts.
The dramatic drop in the game total from 54.5 to 42.5 points tells the story - this projects as a physical, field-position battle where points will be at a premium.
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Best Bet: Under 42.5 (-111)
The combination of Oklahoma's pass rush against Missouri's offensive line, plus both teams' ability to generate pressure, should keep scoring in check. With the Sooners' perfect red zone efficiency meeting the Tigers' third-down prowess, expect a chess match that stays well below the total.