The Los Angeles Lakers are looking to bounce back at home as they welcome the San Antonio Spurs to Crypto.com Arena for what promises to be an intriguing Western Conference battle. The Lakers are coming off a disappointing 108-125 loss to the Phoenix Suns, despite a spectacular 38-point performance from Luka Dončić that wasn't quite enough to secure the victory. They'll lean heavily on the dynamic duo of Dončić and LeBron James to get back in the win column.
Lakers vs Spurs Betting Picks
Meanwhile, the Spurs roll into Los Angeles riding high after an explosive 135-132 victory over the New Orleans Pelicans. That thrilling win was powered by a remarkable 42-point second quarter and a stellar 24-point showing from Harrison Barnes.
However, San Antonio faces a major challenge as they'll be without their franchise cornerstone Victor Wembanyama, who remains sidelined with a calf injury. This absence puts additional pressure on players like De'Aaron Fox to step up against a star-studded Lakers squad.
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Spurs vs Lakers Game Details & Betting Odds
Game Information:
- Date: Wednesday, December 10, 2025
- Time: 10:00 p.m. EST
- Location: Crypto.com Arena (Los Angeles, CA)
- TV: Amazon Prime Video, SportsNet LA
Betting Lines:
- Moneyline: LAL (-286) | SAS (+225)
- Spread: LAL -7.5 (-102) | SAS +7.5 (-118)
- Total: Over/Under 238.5 (-110/-110)
Betting odds courtesy of MGM.
The Lakers enter as significant home favorites, with the moneyline shifting from an opening of -179 to the current -286. The point spread has also moved in their favor, widening from an initial 4.5 points to 7.5 points, indicating strong public backing for Los Angeles to win comfortably. The high total of 238.5 suggests oddsmakers expect a fast-paced, offensive showcase between these Western Conference rivals.
Statistical Breakdown: How the Teams Stack Up
This matchup features two high-octane offensive units with contrasting styles. The Spurs arrive averaging an impressive 119.6 points per game, slightly edging the Lakers' 118.3 points per contest. However, the key difference lies in efficiency. Los Angeles has been remarkably sharp, shooting 50.7% from the field with a league-best 62.2% true shooting percentage. San Antonio shoots a solid 48.5% from the field but will face a daunting task slowing down an LA offense that consistently generates quality looks.
Defensively, the numbers tell a similar story. The Spurs allow 115.3 points per game with a defensive rating of 111.5, while the Lakers give up 116.1 points with a 114.1 defensive rating. Where San Antonio typically excels is on the offensive glass, pulling down 11.5 offensive rebounds per contest and converting them into 16.5 second-chance points. This advantage could prove crucial against a Lakers team that needs to finish possessions cleanly.
The pace battle will be fascinating to watch. San Antonio averages 15.7 fast break points compared to the Lakers' 12.9, showcasing their preference for pushing tempo. With Dončić coming off his 38-point explosion and Barnes providing recent scoring punch for the Spurs, individual matchups will be just as important as the team statistics.
Injury Report: Wembanyama's Absence Looms Large
San Antonio Spurs:
- Victor Wembanyama (F-C): Out (Calf)
- Jordan McLaughlin (G): Questionable (Hamstring)
Los Angeles Lakers:
- Maxi Kleber (F): Questionable (Back)
The headline injury is Wembanyama's continued absence due to a calf injury with no clear return timeline. His unavailability represents a massive blow to San Antonio, particularly against a Lakers team loaded with size and talent in the frontcourt. Without their defensive anchor protecting the paint, the Spurs' ability to generate their usual 16.5 second-chance points per game will be tested.
Guard Jordan McLaughlin's questionable status with a hamstring issue adds another layer of uncertainty for the Spurs' backcourt depth. For Los Angeles, forward Maxi Kleber is questionable with a back problem, though his potential absence wouldn't impact their core rotation as dramatically.
Prediction: Lakers Poised to Exploit Wembanyama's Absence
This matchup heavily favors the home team, and the betting lines accurately reflect that reality. The Lakers aren't just winning games – they're dominating with staggering efficiency, posting a 62.2% true shooting percentage. While the Spurs boast a potent 119.6 points per game offense, their chances of keeping pace take a massive hit without Wembanyama anchoring both ends of the floor.
San Antonio's identity revolves partly around crashing the offensive glass where they grab 11.5 boards per contest, but that advantage diminishes significantly without their franchise big man. Expect the Lakers to control the interior, dictate tempo, and force the Spurs into a more one-dimensional offensive attack. The 7.5-point spread might seem substantial, but given the talent disparity and the critical injury situation, Los Angeles is perfectly positioned for a comfortable home victory.
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Best Bet: Lakers -7.5 (-102). With their offense firing on all cylinders at 50.7% field goal shooting and Wembanyama unavailable to anchor San Antonio's defense, the Lakers should handle this talented but undermanned Spurs squad at home.
Best Player Prop: LeBron James Over Rebounds (-136). The Spurs' strength on the offensive glass is largely tied to Wembanyama's presence. With him sidelined, there will be significantly more defensive rebounding opportunities available, and LeBron will be instrumental in securing those boards to limit second-chance opportunities for San Antonio.