The college football world will turn its attention to Lucas Oil Stadium on Saturday night as two undefeated powerhouses clash in what promises to be one of the most compelling Big Ten Championship games in recent memory. The No. 1 ranked Ohio State Buckeyes bring their championship pedigree and explosive offense to face the No. 2 Indiana Hoosiers, who have authored one of the most remarkable turnaround stories in college football under head coach Curt Cignetti.
Indiana vs Ohio State Betting Picks
This isn't just any conference championship – it's a meeting between programs traveling completely different trajectories. The Buckeyes enter with their typical championship expectations, averaging 37.0 points per game behind head coach Ryan Day's high-powered attack. Meanwhile, the Hoosiers have shattered every preseason prediction, posting an incredible 44.3 points per game while completely transforming the perception of Indiana football in just one season.
The stakes couldn't be higher with College Football Playoff positioning on the line. Both teams sport perfect records and have earned their way to Indianapolis through dominant regular seasons. The winner secures the Big Ten title and likely locks up a top seed in the playoff, while the loser faces uncertainty about their postseason fate. With social media buzzing and both fan bases fired up for this neutral-site showdown, we're breaking down the key matchups and betting angles for what should be an offensive fireworks display.
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Indiana Hoosiers vs. Ohio State Buckeyes Betting Odds
- Moneyline: Ohio State -195, Indiana +162
- Spread: Ohio State -4 (-112)
- Total: Over/Under 47.5 (Over -114 / Under -107)
Betting odds courtesy of consensus odds.
The Buckeyes enter this championship clash as moderate favorites at -195 on the moneyline, while the Hoosiers offer intriguing value as +162 underdogs. The 4-point spread reflects just how competitive oddsmakers expect this game to be, with the line actually tightening from its opening number of 4.5 points as bettors have shown interest in Indiana's chances.
Game Information
- Date: Saturday, December 6, 2025
- Kickoff: 8:00 PM EST
- Venue: Lucas Oil Stadium - Indianapolis, IN
- Weather: Played indoors under controlled conditions
Offensive Firepower Meets Defensive Opportunism
When you examine the numbers, it becomes clear why this matchup has captured the college football world's imagination. The Hoosiers have assembled one of the nation's most explosive offensive attacks, putting up 44.3 points and 483.8 total yards per game. Their foundation is a punishing ground game, coming off a dominant 56-3 victory where they racked up 355 rushing yards.
The Buckeyes counter with their own formidable offense, averaging 37.0 points and 438.5 total yards per game. While they're more balanced between run and pass, Ohio State leans heavily on an aerial assault that generates 267.0 passing yards per game, complemented by a solid rushing attack that produces 171.5 yards on the ground.
The most compelling storyline, however, centers on ball security and defensive playmaking. Indiana's defense has been absolutely predatory this season, generating an astronomical +17 turnover differential thanks to 16 interceptions and 8 fumble recoveries. They've also been disruptive up front with 34 sacks. The Buckeyes have been solid with a +5 turnover margin, securing 7 interceptions and 6 fumble recoveries while recording 30 sacks.
This sets up a fascinating chess match: Can Indiana's ball-hawking defense create the short fields and extra possessions needed to fuel their high-octane offense? Or will Ohio State's experience and talent allow them to protect the football while matching the Hoosiers' scoring pace?
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Big Ten Championship Prediction: Hoosiers Keep It Close in Upset Alert
In a game featuring two high-powered offenses, the deciding factor may come down to which team creates more chaos and capitalizes on mistakes. While the Buckeyes deserve respect as the favorite, there's compelling value backing the underdog Hoosiers to keep this within the number.
Indiana's staggering +17 turnover differential tells the story of a defense that doesn't just stop opponents – it creates game-changing moments. Those 16 interceptions and 8 fumble recoveries have consistently provided short fields for an offense that already leads the nation in scoring. The Hoosiers have shown an elite ability to turn defensive stops into points, a trait that becomes magnified in high-stakes games.
While Ohio State has been solid protecting the football, they haven't faced a defense this opportunistic all season. Indiana's ball-hawking secondary and aggressive pass rush create the type of pressure that can force even experienced quarterbacks into costly mistakes. In a game where both offenses should move the ball effectively, those extra possessions could prove decisive.
The Hoosiers' dominant rushing attack, which just torched their last opponent for 355 yards, also gives them a reliable way to control clock and keep pace with the Buckeyes. With their defense creating turnovers and their ground game eating up yardage, Indiana has the formula to not just cover the spread but potentially pull off the upset.
Best Pick: Indiana +4 (-112)