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Eagles vs Chargers Betting Picks for Monday Night Football

Alex Payton

Eagles vs Chargers Betting Picks for Monday Night Football image

© Bill Streicher-Imagn Images

Monday night brings us a fascinating clash between two 8-6 teams fighting for playoff positioning when the Philadelphia Eagles travel to face the Los Angeles Chargers at SoFi Stadium. Both squads are coming off disappointing losses that snapped potential momentum, making this primetime showdown a crucial bounce-back opportunity.

 

Eagles vs Chargers Betting Picks

The Eagles enter this matchup having dropped two straight games, with team morale reportedly at a low point. Running back Saquon Barkley recently admitted the sideline energy has been "awful," while quarterback Jalen Hurts is working on personal improvements to help turn things around. Meanwhile, the Chargers are looking to capitalize on home-field advantage after their own stumble, with Head Coach Jim Harbaugh emphasizing adaptability in his final preparations.

This contest features elite talent on both sides, headlined by the quarterback duel between Hurts and Justin Herbert. The Eagles boast dynamic playmakers in A.J. Brown and Barkley, while the Chargers counter with defensive stars Khalil Mack and Derwin James Jr. With both teams sitting at identical records and needing wins to solidify their playoff hopes, expect a competitive battle under the Monday night lights.

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Eagles vs Chargers Betting Odds

Date: Monday, December 8, 2025
Kickoff: 8:15 PM EST
Venue: SoFi Stadium, Inglewood, CA

The Eagles enter as slight road favorites in this evenly-matched primetime showdown:

  • Moneyline: Philadelphia Eagles (-130) | Los Angeles Chargers (+110)
  • Spread: Philadelphia Eagles -2.5 (-105)
  • Total: Over/Under 41.5 (Over -112 / Under -108)

Betting odds courtesy of DraftKings.

The tight spread of 2.5 points reflects how evenly matched these teams are on paper. Philadelphia's status as road favorites at -130 suggests oddsmakers see slight edges in their favor, while the Chargers offer decent value at +110 for bettors backing the home team. The relatively low total of 41.5 points indicates expectations of a defensive battle or potentially sloppy offensive play from two teams trying to regain their footing.

Eagles vs Chargers Statistical Breakdown: Contrasting Strengths

This matchup reveals fascinating contrasts in how both teams operate. Offensively, the numbers are nearly identical - the Chargers average 22.8 points per game compared to Philadelphia's 22.5, while Los Angeles generates more total yards with 346.8 per game versus the Eagles' 304.8.

The key difference lies in execution. The Chargers excel at sustaining drives with an impressive 48.3% third-down conversion rate, nearly 14 points better than Philadelphia's 34.5%. However, the Eagles flip the script in the red zone, where they're clinical with a 75.9% touchdown efficiency compared to the Chargers' modest 51.2%. This disparity could be crucial in a tight game where field goals versus touchdowns determine the winner.

Defensively, both teams bring pressure but in different ways. The Chargers have been more effective rushing the passer with 34 sacks compared to Philadelphia's 24. The most telling statistic, though, is ball security. The Eagles protect the football exceptionally well with a +6 turnover differential, while the Chargers sit at -2, having coughed up the ball 14 times this season.

Recent performances highlight key players to watch. Chargers running back Kimani Vidal broke a 59-yard touchdown run in their last outing, while Hurts accounted for three total touchdowns despite the Eagles' losing effort.

Eagles vs Chargers Monday Night Football Pick and Best Bets

 

The statistical tale of two teams reveals why Philadelphia deserves your confidence despite recent struggles. While the Chargers move the ball effectively between the 20-yard lines with that stellar 48.3% third-down rate, the Eagles' ability to finish drives matters more in close games. Their elite 75.9% red-zone touchdown efficiency creates a significant advantage when scoring opportunities arise.

Ball security tells an even more compelling story. Philadelphia's +6 turnover differential demonstrates the discipline that wins tight games, especially compared to Los Angeles sitting at -2. In a contest projected to be decided by a field goal, protecting the football becomes paramount. The Eagles have shown they can be trusted with the ball in crucial moments.

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Best Bet: Philadelphia Eagles -2.5 (-105)

The Eagles' red-zone dominance combined with superior ball security makes them the reliable choice in this pick-em game.

For player props, the turnover narrative creates opportunity. Herbert will face pressure from an Eagles defense that's recorded 8 interceptions this season, while dealing with the hand injury that limited his practice participation. Against a team that forces mistakes and a quarterback who's already thrown multiple picks, the value sits with expecting at least one turnover.

Best Prop Bet: Justin Herbert Over 0.5 Interceptions Thrown (-110)

The combination of Herbert's injury concerns and Philadelphia's opportunistic defense creates favorable odds for this prop.

Eagles vs Chargers Injury Report: Key Players to Monitor

Both teams face significant injury concerns that could impact Monday night's outcome, with 19 players total appearing on the combined injury reports.

Los Angeles Chargers

  • Justin Herbert (QB): Hand - Limited Participation In Practice
  • Tucker Fisk (TE): Ankle - Did Not Participate In Practice

Herbert's hand injury represents the biggest concern for Los Angeles. Limited practice participation for a quarterback always raises red flags about effectiveness, particularly for a player who relies on arm strength and accuracy. The absence of tight end Fisk thins their receiving depth, though other skill players like Quentin Johnston and Omarion Hampton practiced fully.

Philadelphia Eagles

  • Jalen Carter (DT): Shoulder - Did Not Participate In Practice
  • Lane Johnson (T): Foot - Did Not Participate In Practice

Philadelphia faces potentially critical losses on both sides of the trenches. Carter's absence would significantly weaken their interior pass rush, while Johnson's status threatens the protection for Hurts. These non-participations in practice are concerning, especially with Johnson's foot injury potentially compromising the offensive line's effectiveness against the Chargers' pass rush.

The health of these key players could swing the game's outcome, making their final status determinations crucial for both teams' game plans and bettors' considerations.

News Correspondent