Two championship contenders collide in Orchard Park as the Philadelphia Eagles head north to face the Buffalo Bills in what many are calling a potential Super Bowl preview. This late-season showdown pits contrasting offensive philosophies against each other - Buffalo's explosive aerial attack versus Philadelphia's methodical ground-and-pound efficiency.
Eagles vs Bills Week 17 Prediction
The Bills enter this matchup riding high with their high-octane offense averaging 28.8 points per game, led by the dynamic Josh Allen who recently declared his team is in "playoff mode." Meanwhile, the Eagles have quietly transformed into one of the NFL's most clinical red zone units, converting a league-best 71.8% of their scoring opportunities into touchdowns. With Saquon Barkley anchoring a resurgent ground game and A.J. Brown providing explosive plays downfield, Philadelphia has all the pieces to match Buffalo's firepower.
Both defenses bring serious pass-rushing pedigree to this contest, with the Eagles leading slightly at 37.0 sacks compared to Buffalo's 34.0. In a game where protecting the quarterback could determine the outcome, every snap figures to be a chess match between elite front sevens.
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Eagles vs Bills Betting Odds
Mark your calendars for Sunday, December 28, 2025, with kickoff scheduled for 4:25 PM EST. The action unfolds at Highmark Stadium in Orchard Park, NY, where Buffalo will enjoy the home-field advantage in what should be frigid conditions typical of late December in western New York.
- Moneyline: Buffalo Bills (-125) | Philadelphia Eagles (+105)
- Spread: Buffalo Bills -1.5 (-105) | Philadelphia Eagles +1.5 (-115)
- Total: 44 (Over -110 / Under -110)
Betting odds courtesy of MGM.
The oddsmakers see this as essentially a pick 'em game, with Buffalo getting just 1.5 points at home. That razor-thin spread tells the story of two evenly matched teams, while the Eagles' +105 moneyline odds offer solid value for a road underdog capable of winning outright. The 44-point total reflects respect for both defenses despite the offensive firepower on display.
Eagles vs Bills: How These Teams Match Up Statistically
This game sets up as a fascinating contrast in offensive approaches. Buffalo brings the more explosive attack, averaging 373.1 total yards and converting an impressive 45.1% of their third-down attempts. The Bills' ability to sustain drives has been their calling card, allowing them to control games through sheer volume and efficiency between the 20-yard lines.
Philadelphia counters with surgical precision in scoring territory. While averaging a more modest 23.1 points per game, the Eagles' red zone dominance at 71.8% represents the great equalizer in this matchup. When they get close, they finish - a championship-level trait that keeps them competitive against any opponent.
The defensive battle in the trenches promises fireworks, with both teams generating consistent pressure. The Eagles hold a slight edge with 37.0 sacks compared to Buffalo's 34.0, but both units have proven capable of disrupting opposing quarterbacks. Philadelphia's +4 turnover differential also edges Buffalo's +2 mark, suggesting the Eagles have been slightly better at creating short fields and protecting the football.
Recent performances tell an interesting story. The Eagles are coming off a dominant showing that produced 385 total yards, with Barkley finding the end zone to cap an efficient offensive display. Buffalo, meanwhile, managed just 259 total yards in their last outing despite securing the victory - a concerning trend for a team that relies on offensive volume.
Eagles vs Bills Prediction: Philadelphia Offers Value as Road Underdog
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This matchup projects as the ultimate coin flip, with home-field advantage providing Buffalo's only tangible edge. However, the smart money lies with Philadelphia's underdog status, particularly at plus-money odds on the moneyline.
The Eagles' red zone efficiency represents the decisive X-factor in what should be a possession-by-possession battle. While Buffalo excels at moving the ball between the 20s, Philadelphia's ability to maximize scoring opportunities could prove decisive in a tight contest. Their 71.8% red zone touchdown rate significantly outpaces Buffalo's still-respectable 64.3% mark.
Best Bet: Eagles Moneyline (+105)
In a game with such a tight spread, backing the team that converts opportunities into points at an elite level makes perfect sense, especially when getting plus-money odds. The Eagles have shown they can win ugly on the road, and their clinical finishing ability gives them multiple paths to victory even if Buffalo controls yardage totals.
Best Prop Bet: Josh Allen Over 32.5 Rushing Yards (+130)
The Eagles' relentless pass rush has generated 37.0 sacks this season, creating consistent pressure that forces quarterbacks to scramble. Allen's mobility becomes a weapon when pocket protection breaks down, and the plus-money odds fail to account for his ability to clear this total on designed runs or a couple of extended scrambles against an aggressive front.
Final Score Prediction: Eagles 24, Bills 23