We have another third meeting between two divisional rivals in the 2026 NFL Playoffs.
The No. 1-seeded Seattle Seahawks and No. 6 San Francisco 49ers split their meetings this season: San Francisco topped Seattle in Week 1, but the '12' got the (then) last laugh by winning the battle for the NFC's top spot 17-7 in Week 18.
Early odds for Divisional Playoffs round paint this as the biggest blowout of the four games. Is that the proper market read?
Keep scrolling for NFL betting predictions and the best odds to wager for Seahawks vs. 49ers.
49ers vs. Seahawks best bet
49ers +7 (+100) • DraftKings Sportsbook
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49ers vs. Seahawks betting odds
For this list, I'm using DraftKings Sportsbook odds for 49ers vs. Seahawks, current as of Wednesday at 3 p.m. ET.
I will not necessarily use these odds for finding the best bets on this NFC Divisional Round game. (Learn why bettors should use multiple sportsbook apps.)
- Moneyline: 49ers (+275) • Seahawks (-345)
- Spread (ATS): 49ers +7 (+100) • Seahawks -7 (-120)
- Total: Over 45.5 (-105) • Under 45.5 (-115)
- Implied Point Totals Score: Seahawks 26.25, 49ers 19.25
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49ers vs. Seahawks predictions and betting angles
More importantly than analyzing betting trends, which are often deployed in betting punditry universally without context, bettors should consider what angles can affect the event action and follow a betting trail from that.
Here's how Seahawks vs. 49ers bettors should break this game down.
Can 49ers' injury-riddled defense continue hanging on?
They beat the erratic Eagles by a thread in the NFL Wild Card round. Their next challenge is -- for all of the legit Sam Darnold critiques -- a much more consistent offense, with its own impact players: NFL receiving yardage leader Jaxon Smith-Njigba and the running back duo of Kenneth Walker and Zach Charbonnet.
San Francisco has an outside shot of getting linebacker Fred Warner (ankle) back from injured reserve, but this is the biggest point against the Niners' chances of advancing.
George Kittle injury won't slow SF against elite Seattle D
Why is the spread the best bet? QB Brock Purdy will keep things close, even facing one of the league's best defenses.
Even if the Seahawks' elite cornerbacks can contain Jauan Jennings and other wideouts, Jake Tonges has filled in admirably for Kittle often this year, and involving more depth pieces like Brian Robinson Jr. To complement Christian McCaffrey can add another layer to this offense.
🏅 MORE: See where Seahawks and 49ers stars rank in Super Bowl 60 MVP odds.
49ers vs. Seahawks spread bet (ATS)
49ers +7 (+100) • DraftKings Sportsbook
For however much this matters, the Seahawks and 49ers rank among the top five teams for record against the spread.
This leans in favor of Purdy keeping this a one-possession game; Darnold didn't even log a touchdown pass in that Week 18 win over San Francisco.
The fact that we see plenty of 49ers +7.5 with less juice -- and this gives us the possible benefit of a push -- makes this line require a quick pounce before it's corrected.
🎫 MORE: Early NFL Divisional Round lines to bet
49ers vs. Seahawks bet on the Over/Under total
Under 45.5 (-115) • theScore Bet
We'll sacrifice better juice with lower 44 and 44.5 totals for the security of the higher total.
The 49ers likely will want to slow the pace down in order to have a shot to win, which could result in longer drives on their end. And Seattle likely will chew up yardage with the Walker-Charbonnet 1-2 punch in its biggest advantage on offense.
49ers vs. Seahawks moneyline bet to win
49ers (+285) • FanDuel Sportsbook
With little-to-no value in the overwhelming favorite of this matchup, a "low-commitment" bet on the underdog could at least gain some found money in an upset.
49ers vs. Seahawks betting trends data
Again, these should not be considered gospel but can help inform betting decisions on the fringes. Stats include postseason games.
- ATS record 2025: 49ers 11-6-1 • Seahawks 12-5
- Over/Under record 2025: 49ers 10-7-1 • Seahawks 9-8
📋 MORE: How sportsbooks set betting lines
Best sportsbook apps for 49ers vs. Seahawks bets that may be available in your area
Even if sports betting is legal in your state, not all sportsbooks may be available to you. Here are some of the most popular options to look into:
🆓 MORE: How to use bonus bets when signing up for a sportsbook