49ers vs Colts Player Props for Monday Night Football

The ground-and-pound philosophy meets air raid efficiency in this intriguing primetime matchup that presents exceptional value for player prop bettors. The San Francisco 49ers and Indianapolis Colts showcase two of the league's most dominant workhorses in Christian McCaffrey and Jonathan Taylor, who has been bulldozing defenses for an impressive 103.1 rushing yards per game this season. McCaffrey continues his dual-threat excellence, coming off a touchdown performance in the 49ers' commanding 37-24 victory.

49ers vs Colts Player Props and Picks for Monday Night Football

Under center, the quarterback duel features San Francisco's Brock Purdy, fresh off a multi-touchdown showcase, squaring off against Indianapolis's Phillip Rivers, who is making his second start after making his return. With kickoff set for 8:15 p.m. EST at Lucas Oil Stadium, this contest promises fireworks as both offenses look to exploit favorable matchups.

The betting markets have already responded with significant line movement across multiple props, signaling sharp action on key players who figure to dominate touches and target share.

Sign up with the BetMGM bonus code to wager on Monday Night Football to win $150 in bonus bets or get a $1,500 First Bet Offer.

49ers vs Colts Player Props: Complete Betting Board

Passing Props

The quarterback market centers entirely around Purdy's expected aerial assault against Indianapolis. His passing yards total has climbed from an opening number of 241.5 to the current 247.5, reflecting market confidence in his ability to move the ball consistently.

The most telling indicator comes from his touchdown prop, where the over 1.5 passing scores has shifted dramatically from +105 at opening to -149, suggesting widespread belief that he'll find the end zone multiple times through the air.

Rushing and Receiving Props

The skill position markets tell a fascinating story of divergent expectations. Taylor's combined Rushing + Receiving yards prop has surged from 113.5 to 120.5, indicating the market views him as Indianapolis's primary offensive weapon. Conversely, McCaffrey's rushing total dropped from 65.5 to 61.5, suggesting bettors anticipate his production coming more through the passing game where his receiving line moved up to 38.5.

The most dramatic shift belongs to George Kittle, whose receiving yards exploded from 59.5 to 68.5 - a massive nine-yard adjustment that screams target volume and red zone opportunities.

Touchdown Props

The touchdown markets mirror the expected workload distribution, with both feature backs heavily favored to reach paydirt. Taylor's anytime scorer odds shortened from -310 to -242, while McCaffrey moved from -230 to -212, indicating slightly more balanced value. Kittle's first touchdown odds tightened from +750 to +683, aligning with his elevated receiving projection.

49ers vs Colts Player Betting Trends Analysis

• Brock Purdy (Passing TDs): The market has aggressively backed Purdy's multi-touchdown potential, driving his over 1.5 TD prop from +105 to -149. His interception prop simultaneously moved from -115 to -139, reflecting expectations for both high volume and efficiency.
• Jonathan Taylor (Total Production): Taylor's rushing yards sit at 97.5 despite his season average of 103.07 yards per game, creating immediate value. His combined rushing and receiving yards prop surged from 113.5 to 120.5, indicating market recognition of his expanded role.
• George Kittle (Receiving Volume): The most significant individual player movement belongs to Kittle, whose receiving yards rocketed from 59.5 to 68.5. This nine-yard adjustment suggests inside information about his expected target share and red zone involvement.
• Christian McCaffrey (Usage Split): McCaffrey's props show interesting divergence - his rushing total dropped from 65.5 to 61.5 while his receiving yards climbed from 35.5 to 38.5, pointing toward heavier passing game utilization.
• Alec Pierce (Fade Signal): The Colts receiver faces significant market skepticism, with his receiving yards plummeting from 27.5 to 19.5 and his receptions dropping from 2.5 to 1.5.

Best Player Props Bets: 49ers vs Colts Lock Picks

After dissecting the market movement and situational factors, three standout props emerge as premium betting opportunities. The 49ers' offensive efficiency and red zone prowess create ideal conditions for their skill position players, while the Colts' ground-centric attack positions their bell cow for massive production.

New users can score the DraftKings promo code for Monday Night Football to bet $5 and get $200 in bonus bets (if you win).

Lock #1: Jonathan Taylor Over 97.5 Rushing Yards (-118)

The Indianapolis ground game revolves entirely around Taylor's elite production, and the numbers paint a clear picture of value on this total. His consistent workload and proven efficiency against all defensive fronts make this the strongest play on the board.

Statistical Foundation:

• Elite Season Average: Taylor's 103.07 rushing yards per game sits more than five yards above his current prop, providing immediate mathematical edge
• Expected Volume: The 22.5 rushing attempts line projects heavy usage, giving him 22+ carries to accumulate yardage
• Offensive Support: Indianapolis averages 27.7 points per game, ensuring positive game scripts that won't abandon the ground attack

Situational Analysis:
The Colts have built their offensive identity around Taylor's between-the-tackles power and outside zone excellence. Against a 49ers defense that can be susceptible to physical running backs, Taylor's combination of vision and breakaway speed creates multiple paths to eclipsing 100 yards. The betting market has recognized his expanded role by boosting his total yards prop significantly, yet his rushing-specific line remains below his proven production level.

Lock #2: Brock Purdy Over 1.5 Passing Touchdowns (-149)

Despite the heavy juice, Purdy's touchdown prop represents elite process meeting favorable circumstances. The 49ers' offensive system and red zone efficiency create optimal conditions for multiple scoring passes.

Red Zone Dominance:

• Third Down Efficiency: San Francisco converts 49.2% of third down attempts, the league's elite rate for sustaining drives
• Red Zone Touchdown Rate: The 49ers score touchdowns on 63.0% of red zone possessions, capitalizing when they reach scoring position
• Target Quality: Elite receivers like Kittle and McCaffrey provide reliable red zone options who excel in tight coverage

System Advantages:
Kyle Shanahan's offensive scheme creates natural mismatches through motion and formation diversity, particularly near the goal line. Purdy's pocket presence and quick decision-making allow him to exploit defensive weaknesses, while his chemistry with primary targets has developed into automatic connections in crucial situations. The market's aggressive move toward the over reflects widespread recognition of these systemic advantages.

Value Play: George Kittle Over 68.5 Receiving Yards (-115)

The tight end market rarely sees nine-yard adjustments without insider reasoning, making Kittle's elevated total a window into expected game flow and target distribution.

Target Concentration Factors:

• Injury-Related Opportunity: Ricky Pearsall's knee injury removes a key target, funneling additional looks toward established receivers
• Matchup Advantages: Kittle's route versatility creates problems for Indianapolis linebackers and safeties in coverage
• Red Zone Magnet: His combination of size and hands makes him Purdy's preferred target in scoring situations

Market Intelligence:
The dramatic line movement from 59.5 to 68.5 receiving yards suggests market makers expect heavy target volume and efficient production. This adjustment occurred despite Kittle's consistent role, indicating external factors like game script or personnel changes favor his involvement. Combined with Purdy's projected passing success, Kittle profiles as a primary beneficiary of San Francisco's aerial attack.

Correlated Same Game Parlay

Three-Leg SGP:

• Jonathan Taylor Anytime TD (-242)
• George Kittle Over 68.5 Receiving Yards (-115)
• Christian McCaffrey Over 38.5 Receiving Yards (-115)

This combination targets the primary offensive weapons for both teams while capitalizing on expected game flow. Taylor's goal line opportunities pair naturally with the 49ers' passing game success, creating a balanced approach that doesn't rely on one team's complete dominance.