JUMP TO:
Week 5 of the 2025 NFL season begins with the San Francisco 49ers making the trip to Inglewood, California, to take on the Los Angeles Rams for "Thursday Night Football."
Both teams enter the game 3-1, but San Francisco is notably beat up. Starting quarterback Brock Purdy is dealing with a toe injury and was expected to be listed as questionable for the contest. Instead, when the final injury report came out on Wednesday, Purdy was ruled out, paving the way for Mac Jones to start another game for the 49ers.
San Francisco's injury report didn't stop there as Ricky Pearsall and Jauan Jennings were also ruled out for the game, leaving the Niners' offense depleted.
Los Angeles comes into this game off a win over the Indianapolis Colts. Wide receiver Puka Nacua continued his hot start to the season and finished with 170 yards and a touchdown on 13 receptions. Veteran quarterback Matthew Stafford is already up to 1,114 passing yards with eight touchdowns and two interceptions in four games.
Linebacker Byron Young, who leads the Rams and is tied for the overall league lead with five sacks, will look to introduce himself to the San Francisco backfield early and often on Thursday night.
The Sporting News has you covered with LIVE updates, results and highlights from the 49ers-Rams Week 5 "Thursday Night Football" game.
STREAM: Watch 49ers vs. Rams live with Amazon Prime
49ers vs. Rams score
49ers vs. Rams live updates, highlights from Thursday Night Football
7:28 p.m.: With key offensive pieces out, San Francisco is going to need a big game out of superstar running back Christian McCaffrey.
Sights from SoFi 📸 pic.twitter.com/uTnP3KHsIr
— San Francisco 49ers (@49ers) October 2, 2025
The 2023 Offensive Player of the Year is yet to have a rushing touchdown this season. He has 225 yards on 69 carries.
7:20 p.m.: We have more stars out at SoFi Stadium, including LAFC's Son Hueng-Min.
Iconic link up. 🤝 pic.twitter.com/Bvw4QXRoBZ
— Los Angeles Rams (@RamsNFL) October 2, 2025
Son joined Los Angeles from Tottenham Hotspur before the season.
7:03 p.m.: The 49ers and Rams have a detailed history, including the regular season finale in 2021. San Francisco was down 14 points and came all the way back to win the game.
The Week 18 comeback that sent the @49ers to the playoffs in the 2021 season ‼️
— NFL (@NFL) October 2, 2025
SFvsLAR – 8:15pm ET on Prime Video
Also streaming on @NFLPlus pic.twitter.com/5DOXCMfxIp
The two teams met later that season in the NFC Championship. The Rams, who lost to San Francisco twice in the regular season, won en route to their second Super Bowl title.
6:55 p.m.: It's not "Thursday Night Football" in Los Angeles without celebrities. That includes Kirk Herbstreit's dog, Peter.
🗣️ CAN I PET THAT DOG pic.twitter.com/PllyIePeqs
— Los Angeles Rams (@RamsNFL) October 2, 2025
Peter, who travels with his owner to all the "Thursday Night Football" and "College GameDay" sets, is a national celebrity.
6:44 p.m.: ESPN's Adam Schefter has posted the 49ers starting offense for tonight.
49ers offensive starters tonight: pic.twitter.com/nSKkTLVJSe
— Adam Schefter (@AdamSchefter) October 2, 2025
San Francisco has posted its inactives for tonight, including Purdy, Jennings, Pearsall and George Kittle.
Brock Purdy, Ricky Pearsall, and Jauan Jennings are inactive for Week 5.
— San Francisco 49ers (@49ers) October 2, 2025
Full @DignityHealth inactives list: https://t.co/YMP3dVvJMr pic.twitter.com/7OkxUPx2Rx
6:34 p.m.: We have both former 49ers and Rams on the "Thursday Night Football" crew, and they're not afraid to show it. First, it's Richard Sherman, who played for the 49ers from 2018 to 2020.
Start us off, Sherm 😤 pic.twitter.com/oDKC5FWwY5
— San Francisco 49ers (@49ers) October 2, 2025
On the other side, both Ryan Fitzpatrick and Andrew Whitworth played for the Rams. Whitworth won the Super Bowl in 2021 with Los Angeles, his final game before retiring.
Current Rams 🤝 Former Rams pic.twitter.com/t17ErTXCSG
— Los Angeles Rams (@RamsNFL) October 2, 2025
6:20 p.m.: The Rams have arrived for tonight's game, including star wide receiver Davante Adams.
Primetime Tae 🫡 pic.twitter.com/j0WRzRWfzm
— Los Angeles Rams (@RamsNFL) October 2, 2025
Adams, the northern California native, has 46 catches for 633 yards and has scored 7 touchdowns in 5 regular games against San Francisco in his career. He has caught a touchdown in every game.
6:05 p.m.: SoFi Stadium is ready for primetime. As usual, Thursday Night Football will be on Prime Video.
No place like #RamsHouse for primetime. 🤩 pic.twitter.com/Kh1mTKCcMH
— Los Angeles Rams (@RamsNFL) October 2, 2025
Week 4's "Thursday Night Football" broadcast featured the other two NFC West teams with the Seattle Seahawks facing the Arizona Cardinals. Seattle won that contest, 23-20.
5:00 p.m.: San Francisco will be down most of its receiving core with both Ricky Pearsall and Juan Jennings being ruled out. Here are all the active wide receivers for the road team tonight.
The 49ers only activated one WR (Malik Turner) for tonight's game, so their WRs will be:
— Mike Clay (@MikeClayNFL) October 2, 2025
Kendrick Bourne
Demarcus Robinson
Skyy Moore
Marquez Valdes-Scantling
Malik Turner
4:21 p.m.: Mac Jones has arrived ahead of Thursday Night Football. Jones backed up Brock Purdy on Sunday against the Jacksonville Jaguars, but Purdy was ruled out for tonight's contest earlier in the week.
#49ers QB Mac Jones arrives for #TNFonPrime pic.twitter.com/F2LFOu1hxY
— Clayton Holloway (@HollowayNFLN) October 2, 2025
Jones has 563 yards, four touchdowns and an interception in two starts with San Francisco. The 49ers are 2-0 with Jones as a starter.
NFL HQ: Live NFL scores | Updated NFL standings | Full NFL schedule
Where to watch 49ers vs. Rams tonight
49ers vs Rams start time
- Date: Thursday, October 2
- Start time: 8:15 p.m. ET
"Thursday Night Football" between the 49ers and Rams will kick off at 8:15 p.m. ET. The game will be held at SoFi Stadium in Inglewood, California, which means it will begin at 5:15 p.m. PT local time.
MORE NFL: Ranking the greatest 49ers ever
What channel is 49ers vs. Rams on today?
- Date: Thursday, October 2
- TV Channel: None, except local markets
- Live stream: Amazon Prime
The Week 5 matchup between the 49ers and Rams will primarily be carried on Amazon Prime. It will only air on TV in local San Francisco and Los Angeles markets, and will be on a Fox affiliate in those areas.
MORE NFL: Who is on the Mount Rushmore of Bay Area sports?
49ers schedule 2025
| Week | Date | Opponent | Kickoff time (ET) | TV channel |
| 1 | Sunday, Sept. 7 | at Seahawks | 4:05 p.m. | Fox |
| 2 | Sunday, Sept. 14 | at Saints | 1 p.m. | Fox |
| 3 | Sunday, Sept. 21 | vs. Cardinals | 4:25 p.m. | Fox |
| 4 | Sunday, Sept. 28 | vs. Jaguars | 4:05 p.m. | Fox |
| 5 | Thursday, Oct. 2 | at Rams | 8:15 p.m. | Prime Video |
| 6 | Sunday, Oct. 12 | at Buccaneers | 4:25 p.m. | CBS |
| 7 | Sunday, Oct. 19 | vs. Falcons | 8:30 p.m. | NBC |
| 8 | Sunday, Oct. 26 | at Texans | 1 p.m. | Fox |
| 9 | Sunday, Nov. 2 | at Giants | 1 p.m. | CBS |
| 10 | Sunday, Nov. 9 | vs. Rams | 4:25 p.m. | Fox |
| 11 | Sunday, Nov. 16 | at Cardinals | 4:05 p.m. | Fox |
| 12 | Monday, Nov. 24 | vs. Panthers | 8:15 p.m. | ESPN |
| 13 | Sunday, Nov. 30 | at Browns | 1 p.m. | CBS |
| 14 | BYE | — | — | — |
| 15 | Sunday, Dec. 14 | vs. Titans | 4:25 p.m. | Fox |
| 16 | Monday, Dec. 22 | at Colts | 8:15 p.m. | ESPN |
| 17 | Sunday, Dec. 28 | vs. Bears | 8:20 p.m. | NBC |
| 18 | TBD | vs. Seahawks | TBD | TBD |
MORE NFL: Complete list of Super Bowl MVP winners through the years
Rams schedule 2025
| Week | Date | Opponent | Kickoff Time | TV Channel |
| 1 | Sunday, Sept. 7 | vs. Texans | 4:25 p.m. | CBS |
| 2 | Sunday, Sept. 14 | at Titans | 1 p.m. | CBS |
| 3 | Sunday, Sept. 21 | at Eagles | 1 p.m. | Fox |
| 4 | Sunday, Sept. 28 | vs. Colts | 4:05 p.m. | Fox |
| 5 | Thursday, Oct. 2 | vs. 49ers (TNF) | 8:15 p.m. | Prime Video |
| 6 | Sunday, Oct. 12 | at Ravens | 1 p.m. | Fox |
| 7 | Sunday, Oct. 19 | vs. Jaguars (London) | 9:30 a.m. | NFL Network |
| 8 | BYE | — | — | — |
| 9 | Sunday, Nov. 2 | vs. Saints | 4:05 p.m. | Fox |
| 10 | Sunday, Nov. 9 | at 49ers | 4:25 p.m. | Fox |
| 11 | Sunday, Nov. 16 | vs. Seahawks | 4:05 p.m. | Fox |
| 12 | Sunday, Nov. 23 | vs. Buccaneers (SNF) | 8:20 p.m. | NBC |
| 13 | Sunday, Nov. 30 | at Panthers | 1 p.m. | Fox |
| 14 | Sunday, Dec. 7 | at Cardfinals | 4:25 p.m. | Fox |
| 15 | Sunday, Dec. 14 | vs. Lions | 4:25 p.m. | Fox |
| 16 | Thursday, Dec. 18 | at Seahawks (TNF) | 8:15 p.m. | Prime Video |
| 17 | Monday, Dec. 29 | at Falcons (MNF) | 8:15 p.m. | ESPN |
| 18 | TBD | vs. Cardinals | TBD | TBD |