The high-stakes world of the Premier League has claimed its first managerial casualty of the season, with Nottingham Forest's Nuno Espírito Santo now gone.
The focus of the "sack race" has now shifted to several other managers feeling the heat just a few weeks into the campaign.
Based on the latest odds from the major bookmakers, compiled by Oddschecker, here are the three managers considered most likely to be the next to face the axe.
Ruben Amorim (Manchester United) - 10/3
The pressure on Manchester United manager Ruben Amorim has reached boiling point after a humiliating Carabao Cup exit at the hands of League Two side Grimsby Town.
The shock penalty-shootout defeat has brought renewed scrutiny on Amorim, whose team has struggled for form and consistency since the beginning of the season.
The poor start, coupled with the embarrassing cup loss, has seen his odds to be sacked tumble.
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His team has looked disjointed and short on confidence, raising serious questions about his ability to turn things around.
With the team's performances failing to match the expectations of the club's new ownership, a change in management is now seen as a real possibility by the bookies.
Graham Potter (West Ham United) - 4/1
Despite being a popular choice for his previous work at Brighton, Graham Potter's tenure at West Ham has been nothing short of a disaster.
With a dismal run of results that includes a heavy 5-1 defeat to Chelsea and a poor start to the season, the pressure on Potter is mounting rapidly.
The team's defensive frailties and apparent lack of fighting spirit have left them near the bottom of the table.
Potter's odds have been slashed, reflecting the growing belief that his time at the London Stadium is running out.
The fans' patience is wearing thin, and a continuation of this poor form could prove fatal for his future at the club.
Oliver Glasner (Crystal Palace) - 8/1
In a surprising turn of events, Crystal Palace manager Oliver Glasner has seen his odds dramatically shortened.
While he has delivered success for the Eagles, a recent, dramatic transfer saga involving club captain Marc Guéhi and his threatened resignation if the player was sold has reportedly strained his relationship with the club's hierarchy.
This public clash has thrust Glasner into the thick of the sack race, despite his team's solid start to the season.
The bookies believe this internal conflict could be enough to end his time at Selhurst Park, making him a surprise third favourite in the market.
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