The road to Super Bowl 60 has begun with the 2025 NFL season well and truly underway.
With the Philadelphia Eagles' triumph in Super Bowl 59 firmly in the rear-view mirror, all attention is on the new campaign.
The 2025/26 season will once again see three games in London featuring six different teams, all taking place in three consecutive weeks. Two of those games will be played at Tottenham Hotspur Stadium, before the final game will move to Wembley Stadium for the London series finale.
The fabled Kansas City Chiefs are off to a 3-3 having beaten the Lions last time out. However, it's early days and the task remains the same for all 32 sides: Plot a path to Levi's Stadium in Santa Clara, California on February 8, 2026 and a date at the Super Bowl.
But who will follow in the footsteps of the Eagles and emerge as the pre-eminent team in the NFL? The Sporting News has all the latest odds.
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NFL 2025/26 Super Bowl odds, betting and predictions
The Eagles will have no shortage of challengers after thwarting the Kansas City Chiefs' bid for a three-peat in February, their win serving as a reminder to the rest of the NFL that Patrick Mahomes can be defeated on the biggest stage.
With the Chiefs having attacked the issues that proved their downfall and, with multiple teams aiming to follow the Eagles' blueprint, the road to Super Bowl 60 promises to be as competitive as ever.
At least one of the Eagles or Chiefs has contested six of the last eight Super Bowls. The Eagles remain the favourites in the NFC, but the top two teams in the odds are the Baltimore Ravens and the Buffalo Bills.
That makes some sense, as it's exceedingly rare for the same teams to make the Big Game in two consecutive years. And, before the Chiefs won two in a row in 2023 and '24, the last team to repeat was the New England Patriots in '04 and '05.
What do the experts think? Well when it comes to early championship picks, our team of seasoned US Sports writers were divided.
The Sporting News' Vinnie Iyer backed The Eagles. After their Super Bowl win back in February he noted on their 2025/26 prospects: "Jalen Hurts and Saquon Barkley will bring back a loaded offense, and the defense is young enough in key spots to think it will maintain its strength. Philadelphia now has the game's best young coach in Nick Sirianni and Hurts' rise to elite play as Super Bowl MVP gives the team a high ceiling."
Meanwhile, Bill Bender also favours the reigning champions, adding: "Philadelphia is the most consistent team in the NFC in the postseason, although the Eagles will have to fend off the usual contenders again — the Commanders in the NFC East, and the Lions, 49ers and Packers outside the division."
For those seeking an alternative pick, though, look no further than our very own Sloan Piva, who has predicted the Bills to claim the Vince Lombardi Trophy.
He said: "Buffalo made great strides in 2024, fuelled by the heroics of first-time MVP Josh Allen and second-time Pro Bowl running back James Cook. With even one star wideout, Sean McDermott's squad probably would have made Super Bowl 59.
"The Bills have a solid offensive line, a promising defense that will be potent with some pass-rushing reinforcements, and a fairly friendly 2025/26 schedule. Buffalo might finally win its first Super Bowl."
Below are the latest odds for the 2025/26 season, and the teams' various records in 2024/25 for comparison.
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| Team | Odds* | 2024 Record (W-L) |
| Buffalo Bills | 7/1 | 13-4 |
| Kansas City Chiefs | 8/1 | 15-2 |
| Green Bay Packers | 17/2 | 11-6 |
| Detroit Lions | 17/2 | 15-2 |
| Philadelphia Eagles | 12/1 | 14-3 |
| Los Angeles Rams | 16/1 | 10-7 |
| Indianapolis Colts | 20/1 | 8-9 |
* Odds correct at time of publish and subject to change