A classic AFC East rivalry will headline Sunday Night Football on October 5 when the Buffalo Bills host the New England Patriots at Highmark Stadium.
Dating back to the 1960s, the Patriots lead the all-time series against the Bills, 79-51-1. Bills QB Josh Allen is 7-6 against the Patriots.
BUY NOW: Tickets to see Bills vs. Patriots via StubHub
Allen is one of the top players in the league. He’s ready to repeat as MVP. It may not be hard with James Cook, Keon Coleman, Dalton Kincaid, and more by his side.
The Patriots are a long way from the team’s glory days. Going through multiple coaches over the years, Mike Vrabel looks to lead New England past the Bills. QB Drake Maye has reliable weapons in Rhamondre Stevenson and Kayshon Boutte.
Here's everything you need to know about this Week 5 matchup, including links to the best and most affordable tickets.
Bills vs. Patriots tickets for Week 5 NFL game
- Tickets: StubHub
Tickets for the Bills-Patriots game are available now on StubHub!
Ticket prices start at $223.
Prices then range from $300 to $5,679.
BUY NOW: Tickets for Bills vs. Patriots at Highmark Stadium
Bills vs. Patriots start time for Week 5 NFL game
- Date: Sunday, October 5
- Time: 8:20 p.m. ET (7:20 p.m. CT)
The Bills and Patriots will clash on October 5 at 8:20 p.m. ET from Highmark Stadium.
The home of the Bills can hold up to 71,608 people.
Highmark Stadium seat map
Here's the seating map for Highmark Stadium:
Buffalo Bills 2025-26 schedule
Here's the Bills' schedule for 2025. You can purchase tickets to any Buffalo game by clicking here.
| Week | Date | Opponent | Time (ET)/Result |
| 1 | Sun., Sept. 7 | vs. Ravens | W, 41-40 |
| 2 | Sun., Sept. 14 | at Jets | W, 30-10 |
| 3 | Thurs., Sept. 18 | vs. Dolphins | W, 31-21 |
| 4 | Sun., Sept. 28 | vs. Saints | 1 p.m. |
| 5 | Sun., Oct. 5 | vs. Patriots | 8:20 p.m. |
| 6 | Mon., Oct. 13 | at Falcons | 7:15 p.m. |
| 7 | BYE | - | - |
| 8 | Sun., Oct. 26 | at Panthers | 1 p.m. |
| 9 | Sun., Nov. 2 | vs. Chiefs | 4:25 p.m. |
| 10 | Sun., Nov. 9 | at Dolphins | 1 p.m. |
| 11 | Sun., Nov. 16 | vs. Buccaneers | 1 p.m. |
| 12 | Thurs., Nov. 20 | at Texans | 8:15 p.m. |
| 13 | Sun., Nov. 30 | at Steelers | 4:25 p.m. |
| 14 | Sun., Dec. 7 | vs. Bengals | 4:25 p.m. |
| 15 | Sun., Dec. 14 | at Patriots | 1 p.m. |
| 16 | Sun., Dec. 21 | at Browns | 1 p.m. |
| 17 | Sun.. Dec. 28 | vs. Eagles | 4:25 p.m. |
| 18 | Sun., Jan. 4 | vs. Jets | TBD |
New England Patriots 2025-26 schedule
Here's the Patriots' schedule for 2025. You can purchase tickets to any New England game by clicking here.
| Week | Date | Opponent | Time (ET)/Result |
| 1 | Sun., Sept. 7 | vs. Raiders | L, 20-13 |
| 2 | Sun., Sept. 14 | at Dolphins | W, 33-27 |
| 3 | Sun., Sept. 21 | vs. Steelers | 1 p.m. |
| 4 | Sun., Sept. 28 | vs. Panthers | 1 p.m. |
| 5 | Sun., Oct. 5 | at Bills (SNF) | 8:20 p.m. |
| 6 | Sun., Oct. 12 | at Saints | 4:25 p.m. |
| 7 | Sun., Oct. 19 | at Titans | 1 p.m. |
| 8 | Sun., Oct. 26 | vs. Browns | 1 p.m. |
| 9 | Sun., Nov. 2 | vs. Falcons | 1 p.m. |
| 10 | Sun., Nov. 9 | at Buccaneers | 1 p.m. |
| 11 | Thurs., Nov. 13 | vs. Jets (TNF) | 8:15 p.m. |
| 12 | Sun., Nov. 23 | at Bengals | 1 p.m. |
| 13 | Mon., Dec. 1 | vs. Giants (MNF) | 8:15 p.m. |
| 14 | Sun., Dec. 7 | BYE | — |
| 15 | Sun., Dec. 14 | vs. Bills | 1 p.m. |
| 16 | Sun., Dec. 21 | at Ravens | 1 p.m. |
| 17 | Sun., Dec. 28 | at Jets | 1 p.m. |
| 18 | Sun., Jan. 4 | vs. Dolphins | TBD |