The Cardinals and 49ers continue a classic NFC West rivalry on September 21 when San Francisco hosts Arizona at Levi’s Stadium.
The Week 3 matchup is the latest chapter in a rivalry that started in 1951. San Francisco leads the series, 36-31.
After multiple injuries last season, Christian McCaffrey looks to return to form this year. Meanwhile, George Kittle is ready to produce for QB Brock Purdy, while pickup Brian Robinson Jr. gears up for a new era in San Francisco.
BUY NOW: Tickets for 49ers vs. Cardinals via StubHub
The Cardinals hope to make the playoffs following a three-year absence. QB Kyler Murray is confident in his abilities. That isn't hard with weapons like Marvin Harrison Jr., Trey Benson, James Conner, and Trey McBride at his disposal.
Who will take home bragging rights in this early 2025 matchup?
Here's everything you need to know about this Week 3 matchup, including links to the best and most affordable tickets.
49ers vs. Cardinals tickets for Week 3 NFL game
- Tickets: StubHub
Tickets for the 49ers vs. Cardinals game are available now on StubHub!
Ticket prices start at $143.
Prices then range from $200 to $5,798.
BUY NOW: Tickets for 49ers vs. Cardinals at Levi's Stadium
49ers vs. Cardinals date, time for Week 3 NFL game
- Date: Sunday, September 21
- Time: 4:25 p.m. ET (3:25 p.m. CT)
The 49ers vs. Cardinals game will be on September 21 at 4:25 p.m. ET from Levi's Stadium.
The home of the 49ers can hold up to 68,500 people.
Levi's Stadium seat map
Here's the seating map for Levi's Stadium:
Levi's Stadium
San Francisco 49ers 2025-26 schedule
Below is a look at every game on San Francisco's 2025 schedule. Click here for tickets to every matchup.
| Week | Date | Game | Time (ET) |
| 1 | Sun., Sept. 7 | at Seahawks | 4:05 p.m. |
| 2 | Sun., Sept. 14 | at Saints | 1 p.m. |
| 3 | Sun., Sept. 21 | vs. Cardinals | 4:25 p.m. |
| 4 | Sun., Sept. 28 | vs. Jaguars | 4:05 p.m. |
| 5 | Thurs., Oct. 2 | at Rams | 8:15 p.m. |
| 6 | Sun., Oct. 12 | at Buccaneers | 1 p.m. |
| 7 | Sun., Oct. 19 | vs. Falcons | 8:20 p.m. |
| 8 | Sun., Oct. 26 | at Texans | 1 p.m. |
| 9 | Sun., Nov. 2 | at Giants | 1 p.m. |
| 10 | Sun., Nov. 9 | at Rams | 4:25 p.m. |
| 11 | Sun., Nov. 16 | at Cardinals | 4:05 p.m. |
| 12 | Mon., Nov. 24 | vs. Panthers | 8:15 p.m. |
| 13 | Sun., Nov. 30 | at Browns | 1 p.m. |
| 14 | BYE | - | - |
| 15 | Sun., Dec. 14 | vs. Titans | 4:25 p.m. |
| 16 | Mon., Dec. 22 | at Colts | 8:15 p.m. |
| 17 | Sun., Dec. 28 | vs. Bears | 8:20 p.m. |
| 18 | TBD | vs. Seahawks | TBD |
Arizona Cardinals 2025-26 schedule
Below is a look at every game on Arizona's 2025 schedule. Click here for tickets to every matchup.
| Week | Date | Game | Time (ET) |
| 1 | Sun., Sept. 7 | at Saints | 1 p.m. |
| 2 | Sun., Sept. 14 | vs. Panthers | 4:05 p.m. |
| 3 | Sun., Sept. 21 | at 49ers | 4:25 p.m. |
| 4 | Thurs., Sept. 25 | vs. Seahawks | 8:15 p.m. |
| 5 | Sun., Oct. 5 | vs. Titans | 4:05 p.m. |
| 6 | Sun., Oct. 12 | at Colts | 1 p.m. |
| 7 | Sun., Oct. 19 | vs. Packers | 4:25 p.m. |
| 8 | BYE | - | - |
| 9 | Mon., Nov. 3 | at Cowboys | 8:15 p.m. |
| 10 | Sun., Nov. 9 | at Seahawks | 4:05 p.m. |
| 11 | Sun., Nov. 16 | vs. 49ers | 4:05 p.m. |
| 12 | Sun., Nov. 23 | vs. Jaguars | 4:05 p.m. |
| 13 | Sun., Nov. 30 | at Buccaneers | 1 p.m. |
| 14 | Sun., Dec. 7 | vs. Rams | 4:25 p.m. |
| 15 | Sun., Dec. 14 | at Texans | 1 p.m. |
| 16 | Sun., Dec. 21 | vs. Falcons | 4:05 p.m. |
| 17 | TBD | at Bengals | TBD |
| 18 | TBD | at Rams | TBD |