Your fantasy football semi-final playoff match-up could be decided tonight! Monday Night Football finds the San Francisco 49ers heading into Indianapolis to battle the Colts. Both are fighting for post-season positioning, but which players are ready to help your fantasy team the most?
✅ Starts (PPR)
49ers
- Christian McCaffrey, RB: The safest start in fantasy. Elite receiving usage keeps his PPR floor sky-high. Six total touchdowns over the past four games. Slight concern over his PPR point totals dropping to the mid-teens over the last two weeks. Regardless, a no-brainer play.
- George Kittle, TE: A premium red-zone option with consistent target volume, and five of his six touchdowns coming since Week 8. Elite 20-plus fantasy point production in three of his last five. Colts have also allowed the 10th most FPTS to tight ends.
- Brock Purdy, QB: If you have to choose from one of the two quarterbacks playing on MNF, Purdy is the obvious choice. Coming off a stellar fantasy day against Tennessee (3-TDs/0-INTs, 295-yards), he’ll face a stiffer test in the Indianapolis defense.
- Jauan Jennings, WR: Four scores, and mid-to-high teen fantasy points in four of his last five outings, makes Jennings a strong option. The absence of Ricky Pearsall tonight (knee injury), and that the Colt’s allow the third most FPTS to wide receivers, are two more reasons to get him into your lineup.
Colts
- Jonathan Taylor, RB: Heavy touch projection and goal-line work keep him locked in. However, his sky high output has plummeted since the Colts’ bye. From Week 12-to-15, Taylor was RB-20 in PPR formats, with just a single TD.
- Michael Pittman Jr., WR: Under Daniel Jones, Pittman emerged as a target hog with double-digit PPR upside. 44-year old Philip Rivers on the other hand…well…it’s understandably downgraded his appeal. Pittman is still startable, just as long as your expectations are set at fringe WR-3 or Flex levels.
❌ Sits (PPR)
49ers
- Brian Robinson Jr., RB: He’s struggled in the change of pace role behind McCaffrey. Provides little upside, and is strictly a bench stash handcuff.
- Demarcus Robinson, WR: Ricky Pearsall being out may raise him up the 49ers depth chart, but Robinson is still very much a TD or bust option. Expect any extra Pearsall reps to be distributed between CMC, Kittle, Jennings, and Kendrick Bourne.
Colts
- Philip Rivers, QB: While it’s a fun story, relying on a freshly un-retired Phil Rivers to advance to your fantasy championship would be a fool's errand.
- Ameer Abdullah, RB: He may have been Rivers' top receiver (5-receptions) last Sunday, it’s probably best to avoid Jonathan Taylor’s backup.
- Alec Pierce, WR: A single target in Rivers’ debut, plus a run heavy offense, equals “stay away” vibes.
🌟 Sleeper Pick
- 49ers — Kendrick Bourne, WR (4% rostered): Bourne was at his best in 2025 when Ricky Pearsall missed six games. During that stretch, the nine-year veteran recorded consecutive 142-receiving yard outings. With Pearsall out again this evening, expect another increase in opportunities.
Set your lineups wisely—this Monday Night showdown could decide a trip to your fantasy football championships! 🏆