With just two weeks of regular-season play remaining, there are still plenty of playoff positions to be determined, milestones to be reached and individual performances that could wind up in the record books.
Here's what to watch for in NFL Week 16 action:
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The return of record-breaking Brady
It's been a somewhat uneventful season for Patriots quarterback Tom Brady, but that could change Sunday.
Brady ranks fifth in the league with 3,979 passing yards this season. With 21 more against the Bills, he can join Peyton Manning and Drew Brees as the only quarterbacks in NFL history to record at least 10 seasons with at least 4,000 passing yards.
Chargers quarterback Phillip Rivers, who is tied for seventh in the league with 3,951 passing yards, could also join the elite company Saturday against the Ravens.
| Player | Team(s) | Seasons with 4,000+ passing yards |
|---|---|---|
| Peyton Manning | Indianapolis, Denver | 14 |
| Drew Brees | New Orleans | 12 |
| Tom Brady | New England | 9* |
| Philip Rivers | Los Angeles Chargers | 9* |
Baker on the rise
Browns quarterback Baker Mayfield is poised to keep his breakout season going.
Mayfield leads all rookies with 21 touchdown passes in 2018. If he can manage three scoring passes Sunday against the Bengals, he would surpass Andrew Luck for the second-most touchdown passes by a rookie quarterback selected No. 1 overall in the common draft era.
The most touchdown passes by a rookie selected No. 1 overall in that time:
| Player | Team | Season | Passing touchdowns |
|---|---|---|---|
| Peyton Manning | Indianapolis | 1998 | 26 |
| Andrew Luck | Indianapolis | 2012 | 23 |
| Jameis Winston | Tampa Bay | 2015 | 22 |
| Baker Mayfield | Cleveland | 2018 | 21* |
| Cam Newton# | Carolina | 2011 | 21 |
#Named Associated Press Offensive Rookie of the Year
Mighty McCaffrey
Carolina's playoff hopes may be shattered, but Panthers running back Christian McCaffrey has more work to do.
McCaffrey leads all running backs with 94 receptions this season, and has the opportunity to surpass Matt Forte for the most catches by a running back in a single season in NFL history if he can get nine more Sunday against the Falcons.
The rushers with the most receptions in a single season in NFL history:
| Player | Team | Season | Receptions |
|---|---|---|---|
| Matt Forte | Chicago | 2014 | 102 |
| Larry Centers | Arizona | 1995 | 101 |
| LaDainian Tomlinson^ | San Diego | 2003 | 100 |
| Larry Centers | Arizona | 1996 | 99 |
| Chrstian McCaffrey | Carolina | 2018 | 94* |
^Pro Football Hall of Famer
Saquon can do it all
Giants running back Saquon Barkley is on the verge of yet another record, but it's not on the ground.
Barkley leads all rookies with 82 receptions. With seven more at Indianapolis on Sunday, he can surpass Reggie Bush for the most catches by a rookie rusher in league annals.
The rookie running backs with the most receptions in a season:
| Player | Team | Season | Receptions |
|---|---|---|---|
| Reggie Bush | New Orleans | 2006 | 88 |
| Earl Cooper | San Francisco | 1980 | 83 |
| Saquon Barkley | New York Giants | 2018 | 82* |
Kelce's career season
Chiefs tight end Travis Kelce has more than the AFC West division title riding on his performance this week.
Kelce leads all tight ends with a career-high 1,220 receiving yards in 2018, and can surpass Rob Gronkowski for the most receiving yards by a tight end in a single season in NFL history if he can manage 108 more Sunday night against the Seahawks.
The tight ends with the most receiving yards in a single season in NFL history:
| Player | Team | Season | Receiving yards |
|---|---|---|---|
| Rob Gronkowski | New England | 2011 | 1,327 |
| Jimmy Graham | New Orleans | 2011 | 1,310 |
| Kellen Winslow^ | San Diego | 1980 | 1,290 |
| Tony Gonzalez | Kansas City | 2004 | 1,258 |
| Todd Christensen | Los Angeles Raiders | 1983 | 1,247 |
| Travis Kelce | Kansas City | 2018 | 1,220* |
^Pro Football Hall of Famer