Week 14 was wild and challenging with AllSportsPeople' picks and predictions against the spread. Injuries were in play as well as upsets in key games.
But with only four weeks left in the 2025 NFL regular season, the only thing to do is get right back on that holiday horse with another fearless forecast for Week 15:
POWER RANKINGS: Packers, Steelers jump as Chiefs, Colts slide again in Week 15
NFL picks against the spread for Week 15
Game of Midweek: Falcons at Buccaneers (-4.5, 44.5 o/u)
Thursday 8:15 p.m. ET, Amazon Prime Video
The Falcons are facing an injury-riddled freefall for their offense and after an OK start, Raheem Morris' defense is getting destroyed The Bucs will rebound well from their slogging loss to the Saints at home with possible extra help for Baker Mayfield and Bucky Irving. They just need to contain Bijan Robinson from big runs.
Pick: Buccaneers win 27-20 and cover the spread.
Game of the Week: Packers (-2, 42.5 o/u) at Broncos
Sunday 4:25 p.m. ET, CBS
Jordan Love is on a heater with big passing efforts against the Lions and Bears. Denver's defense on the road presents a bigger challenge but support from the running game and the diversity of weapons can help him put up winning production. Bo Nix will face a tough defense led by Micah Parsons on the other side, something he won't overcome as well.
Pick: Packers win 23-20 and cover the spread.
NFL STANDINGS: Updated AFC, NFC playoff pictures after Week 14
Lock of the Week: 49ers (-12.5, 44.5) over Titans
Sunday 4:25 p.m. ET, Fox
George Kittle spends his tight end offseasons in Nashville, but he won't be so kind to the visitors from Tennessee with San Francisco's offense getting healthier and more focused after a welcome Week 14 bye. The Titans got another win, but they are bound to cool off with Cam Ward after Brock Purdy picks them apart with Kittle, Christian McCaffrey and others.
Pick: 49ers win 34-13 and cover the spread.
Upset of the Week: Lions (+5.5, 54 o/u) over Rams
Sunday I p.m. ET, CBS
The Lions are feeling confident in their offense again in this latest QB duel between former Ram Jared Goff and former Lion Matthew Stafford. The Rams can move the ball well on Detroit's defense, but Los Angeles also has plenty of holes to exploit on the back end. Between Amon-Ra St. Brown, Jameson Williams, Jahmyr Gibbs, Puka Nacua, Davante Adams and Kyren Williams, there's too much receiver and back talent not to expect a SoFi shootout. The Lions steal it late with a lot of Gibbs.
Pick: Lions win 34-31.
Browns at Bears (-7, 40 o/u)
Sunday 1 p.m. ET, Fox
Shedeur Sanders tried to prove head-to-head with Ward he's the best rookie QB in his class, despite being a fifth-round pick. But now he faces the legit No. 1 overall pick in the 2024 draft, Caleb Williams. Williams was upset about his late interception in Green Bay and will be ready to make amends vs. Cleveland, a defense that was surprisingly leaky at home in Week 14 and isn't as good on the road.
Pick: Bears win 24-14 and cover the spread.
MORE: Ben Johnson's questionable clock management dooms Bears
Ravens (-2.5, 51.5 o/u) at Bengals
Sunday 1 p.m. ET, CBS
The Ravens couldn't get swept by the Bengals in a span of three weeks, could they? Sure they can. Baltimore was ripped by Pittsburgh's dormant passing game and Joe Burrow, before the game-sealing late interceptions, was blowing through Buffalo in the snow. The Bengals continue to match up well and the Ravens' secondary is vulnerable. Lamar Jackson and Derrick Henry aren't doing enough to overcome that.
Pick: Bengals win 24-20.
Chargers at Chiefs (-4.5, 43.5 o/u)
Sunday 1 p.m. ET, CBS
The Chargers will be coming into Kansas City on a short week with a banged-up QB, Justin Herbert. They won the first wild meeting in Week 1 late, but it would be difficult to do it again. There's not much wrong with KC's defense, except a lacking pass rush, which can get going vs. Herbert's shaky pass protection. The Chiefs will grind this out to maintain a playoff picture pulse.
Pick: Chiefs win 20-17 but fail to cover the spread.
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- What Chiefs' loss to Texans means for 2025 playoff chances
- Kansas City's nine-year divisional streak snaps with Texans loss
Bills (-1.5, 49.5 o/u) at Patriots
Sunday 1 p.m. ET, CBS
Josh Allen and Buffalo are getting the buzz as the team to beat in the AFC, despite the fact at 9-4, they still trail New England by two games and lost the first matchup at home. The Patriots also enjoyed a Week 14 bye to further settle Drake Maye and the defense for Josh McDaniels and coach of the year Mike Vrabel. The Patriots have shown the better overall D, while the Bills still have too many holes on that side.
Pick: Patriots win 27-24.
Commanders at Giants (-2.5, 47.5 o/u)
Sunday 1 p.m. ET, Fox
The Commanders are facing an offseason nightmare in hoping that Jayden Daniels can be healthy enough to return to rookie form vs. The lost 2025 campaign. The Giants should see that cautionary tale and do better to protect Jaxson Dart, also calling upon him to be smarter with his body after the bye. Mike Kafka has the Giants playing inspired and will work them out of the NFC cellar vs. A fading, aging team.
Pick: Giants win 24-20 and cover the spread.
Mike Dinovo-Imagn Images
Raiders at Eagles (-12.5, 38.5 o/u)
Sunday 1 p.m. ET, Fox
The Raiders are going through the motions except for their most talented players, including Maxx Crosby, Brock Bowers and Ashton Jeanty. Losing Geno Smith to injury didn't make things better with former Eagle Kenny Pickett also stuck in the new offense. The Eagles will immensely enjoy this needed all-around get-well game for Jalen Hurts and all of his weapons.
Pick: Eagles win 38-17 and cover the spread.
MORE: 6 Eagles most to blame for offensive struggles
Jets at Jaguars (-11.5, 42 o/u)
Sunday 1 p.m. ET, CBS
The Jets saw Tyrod Taylor get hurt and got stuck with Brady Cook at QB. The Jaguars won't care who the QB is; they'll see chum in the water and attack like sharks on defense. Offensively, Trevor Lawrence and his receivers plus Travis Etienne Jr. In the running game are starting to put it all together in Liam Coen's offense at the right time.
Pick: Jaguars win 30-14 and cover the spread.
Cardinals at Texans (-9.5, 42.5 o/u)
Sunday 1 p.m. ET, Fox
The Cardinals have been game with their backup offense led by Jacoby Brissett, Michael Wilson and Bam Knight but they're always producing it seems in trailing garbage time. Jonathan Gannon's defense has fallen apart, not right for a J.J. Watt Bowl. The Texans, however, can keep honoring their GOAT's legacy with more dominant, physical and fundamentally sound play.
Pick: Texans win 27-14 and cover the spread.
Brian Fluharty-Imagn Images
Panthers (-2.5, 40.5 o/u) at Saints
Sunday 4:25 p.m. ET, Fox
Which Panthers team will show up? The one that beat the Packers, Rams and Cowboys... Or the one that lost to the 49ers, Bills and Saints? Carolina lost 17-7 at New Orleans in Week 10 with anemic offense. The hosts will be back on track there with Dave Canales after the bye and on sharp upset alert after the Saints helped them by shocking the Bucs last week.
Pick: Panthers win 20-17 and cover the spread.
Colts at Seahawks (-11.5, 42.5 o/u)
Sunday 4:25 p.m. ET, CBS
Daniel Jones' comeback story was inspiring while it lasted. But now the Colts face the prospect of Riley Leonard starting against a tough Seattle pass defense on the road that also doesn't give up much on the ground. That will limit Jonathan Taylor's support for the second-year QB. On the flip side, Sam Darnold needed that second half in Atlanta to get right and his receivers match up well against Sauce Gardner-less coverage.
Pick: Seahawks win 34-17 and cover the spread.
MORE: How Colts' Super Bowl chances take massive hit with Daniel Jones injury
Vikings at Cowboys (-6, 47.5 o/u)
Sunday 8:20 p.m. ET, NBC/Peacock
Minnesota got some promise from J.J. McCarthy to lead the victory at home, but it was the defense making the much-needed big statement to keep faint playoff hopes alive. Dallas lost to Detroit to hurt its fading chances, but it is a different kind of explosive, efficient offensive machine at home. Dak Prescott will hope CeeDee Lamb will be cleared with extra time, but regardless, he can execute better with his weapons than McCarthy can.
Pick: Cowboys win 31-24 and cover the spread.
Dolphins at Steelers (-3.5, 42 o/u)
Monday 8:15 p.m. ET, ESPN
Mike Tomlin and Aaron Rodgers have flipped the narrative on the team's play with just one big game at Baltimore. Now Pittsburgh faces a different 6-7 team trying to save its own coach, Mike McDaniel. Look for Jalen Ramsey to make the winning play vs. Tua Tagovailoa to seal it as this cold road matchup is rough for Tua Tagovailoa.
Pick: Steelers win 27-20 and cover the spread.
Stats of the Week
- Week 14 record straight up: 7-6
- Week 14 record against the spread: 3-10
- 2025 season record straight up: 132-73
- 2025 season record against the spread: 100-109