Last week, we saw five underdogs outright win on Sunday afternoon (Jets, Giants, Texans, Cowboys, and Colts), and the Falcons covered their double-digit spread against the Bucs to stay a perfect 5-0 ATS this season. Week 6 should bring us more betting action and fun despite a lackluster Thursday Night Football matchup between the Commanders and Bears. However, on Sunday afternoon, we have a solid 12-game schedule beginning at 1 p.m. ET where bettors will be looking to cash in on player props, sides, totals, and money line.
Outside of the 12 games on Sunday, we have a pivotal AFC West matchup next Monday night between the Broncos and Chargers in Los Angeles. The Chargers are six-point favorites after coming off a tough win over the Browns on the road, while the Broncos are trying to snap their two-game losing skid and pick up a win in the division. We also have our first set of byes this season with the Lions, Titans, Raiders, and Texans getting a much-needed week off.
Please remember that the odds and lines will move throughout the week as we get updates on various injuries across the league. There could be some opportunity for closing line value (CLV) in a few games leading up to kickoff. Below, we take a look at the latest odds for Week 6 from Caesars Sportsbook and provide a few best bets that need to be on your radar.
NFL odds Week 6
Odds courtesy of Caesar's and updated on Sunday morning at 11 AM ET
| Game | Spread |
| Washington Commanders at Chicago Bears | PK |
| Minnesota Vikings at Miami Dolphins | MIN -3 |
| Baltimore Ravens at New York Giants | BAL -5.5 |
| New England Patriots at Cleveland Browns | CLE -2.5 |
| Cincinnati Bengals at New Orleans Saints | CIN -3 |
| San Francisco 49ers at Atlanta Falcons | SF -4 |
| New York Jets at Green Bay Packers | GB -7.5 |
| Tampa Bay Buccaneers at Pittsburgh Steelers | TB -9.5 |
| Jacksonville Jaguars at Indianapolis Colts | IND -1.5 |
| Arizona Cardinals at Seattle Seahawks | AZ -3 |
| Carolina Panthers at Los Angeles Rams | LAR -10 |
| Buffalo Bills at Kansas City Chiefs | BUF -2.5 |
| Dallas Cowboys at Philadelphia Eagles | PHI -6.5 |
| Denver Broncos at Los Angeles Chargers | LAC -4.5 |
NFL moneylines Week 6
| Game | Moneyline |
| Washington Commanders at Chicago Bears | WSH -110 | CHI -110 |
| Minnesota Vikings at Miami Dolphins | MIN -165 | MIA +140 |
| Baltimore Ravens at New York Giants | BAL -267 | NYG +215 |
| New England Patriots at Cleveland Browns | NE +118 | CLE -140 |
| Cincinnati Bengals at New Orleans Saints | CIN -170 | NO +143 |
| San Francisco 49ers at Atlanta Falcons | SF -210 | ATL +175 |
| New York Jets at Green Bay Packers | NYJ +285 | GB -365 |
| Tampa Bay Buccaneers at Pittsburgh Steelers | TB -455 | PIT +345 |
| Jacksonville Jaguars at Indianapolis Colts | JAX +105 | IND -125 |
| Arizona Cardinals at Seattle Seahawks | AZ -145 | SEA +122 |
| Carolina Panthers at Los Angeles Rams | CAR +345 | LAR -455 |
| Buffalo Bills at Kansas City Chiefs | BUF -145 | KC +122 |
| Dallas Cowboys at Philadelphia Eagles | DAL +228 | PHI -285 |
| Denver Broncos at Los Angeles Chargers | DEN +180 | LAC -220 |
NFL over/unders Week 6
| Game | Over/Under |
| Washington Commanders at Chicago Bears | 38.5 |
| Minnesota Vikings at Miami Dolphins | 45 |
| Baltimore Ravens at New York Giants | 45.5 |
| New England Patriots at Cleveland Browns | 43 |
| Cincinnati Bengals at New Orleans Saints | 42.5 |
| San Francisco 49ers at Atlanta Falcons | 45.5 |
| New York Jets at Green Bay Packers | 45.5 |
| Tampa Bay Buccaneers at Pittsburgh Steelers | 46 |
| Jacksonville Jaguars at Indianapolis Colts | 41 |
| Arizona Cardinals at Seattle Seahawks | 50.5 |
| Carolina Panthers at Los Angeles Rams | 41.5 |
| Buffalo Bills at Kansas City Chiefs | 54.5 |
| Dallas Cowboys at Philadelphia Eagles | 42 |
| Denver Broncos at Los Angeles Chargers | 45.5 |
NFL best bets for Week 6
Bengals (-170) at Saints
The Bengals are coming off a tough road loss to the Ravens in Week 5, while the Saints snuck away with a seven-point win at home over Seattle. Cincinnati should be able to ride its defense (17.8 points, 99.6 rushing yards per game) to a win over a Saints squad that is banged up on offense (Jameis Winston, Michael Thomas, Jarvis Landry, Chris Olave). This should be a big Joe Mixon game, too, as the Saints' defense is allowing 130 rushing yards per game. Cincinnati is 4-2 straight up in their past six games against New Orleans and 5-1 ATS over that span.
Falcons (+4) vs. 49ers
It's only right for us to take the Falcons to cover the spread at home against the 49ers. Even though they lack talent at a bunch of skill positions, Atlanta head coach Arthur Smith has his team playing competitive football. In their three losses this season, the Falcons have only lost by 3.6 points per game. They've played the Buccaneers, Rams, and Browns all tough this season. The Niners are riding a two-game winning streak, but I don't believe they are almost a touchdown better than Atlanta. San Francisco beat up the Panthers and took down the Rams at SoFi Stadium in consecutive weeks. However, they also lost to Denver in a slop fest of a game. With Drake London set to play and the Falcons' ability to run the ball, they will keep it close at home.
Cardinals vs. Seahawks (+115)
Every week in the NFL, there's always guaranteed to be a few upsets that catch football fans and bettors off guard. In Week 6, we will take Seattle to pull the upset at home over Kyler Murray and Arizona. Seattle has played good complementary football through the first five games of the season. Geno Smith has been locked in under center, completing 75 percent of his passes for 1,305 yards, nine touchdown passes, and two interceptions. The Seahawks will be without Rashaad Penny (fractured fibula), but they have a good rookie running back in Kenneth Walker III. Both teams' defenses will give up a ton of points, but you gotta love the consistency Smith and the offense are playing with. Take the Seahawks to pull the upset in the waning moments of the fourth quarter.