George Kittle was having his best game of the season against the Indianapolis Colts on "Monday Night Football," reeling in over 100 yards and a touchdown. But the 49ers star tight end suffered an apparent injury on San Francisco's final drive of the third quarter.
Kittle was noticeably frustrated on the sidelines after the injury and did not return to the game, which the 49ers' won 48-27.
Here are the latest updates on the 49ers star's status.
George Kittle injury updates
After the 49ers' 48-27 win, head coach Kyle Shanahan said that it is too soon to determine the severity of Kittle's injury.
Kyle Shahanan said it’s too soon to determine the severity of George Kittle’s ankle injury
— Sleeper49ers (@SleeperSF49ers) December 23, 2025
Kittle will have further testing tomorrow pic.twitter.com/MIXmVyssoa
Kittle did not return to the game after leaving. He was questionable to return with an ankle injury.
49ers TE George Kittle is questionable to return tonight due to an ankle injury.
— Adam Schefter (@AdamSchefter) December 23, 2025
*This story will be updated with the latest available information.
What happened to George Kittle?
In the 49ers' final drive of the third quarter, Kittle suffered an ankle injury while running a route. The tight end was in noticeable frustration.
ESPN's broadcast showed a shot of Kittle warming up, but he did not return to the game. He was seen celebrating on the field afterwards.
George Kittle didn't finish tonight's game because of an ankle injury, but was all smiles on the field after the game.
— Adam Hoge (@AdamHoge) December 23, 2025
Have to think it would take a lot for him not to play Sunday night against the team he grew up cheering for.
The tight end led the team in receiving on Monday night with seven catches for 115 yards and a touchdown.