The New Orleans Saints (0-3) travel north to Orchard Park in Week 4, where they’ll square off with the unbeaten Buffalo Bills (3-0) at Highmark Stadium.
New Orleans enters the contest still searching for their first win of the season after being dismantled 44-13 by the Seattle Seahawks in their previous outing. Following this matchup, the Saints return to the Superdome for a clash with the New York Giants.
Buffalo, meanwhile, has been firing on all cylinders, improving to 3-0 after a 31-21 triumph over the Miami Dolphins last week. The Bills will look to keep their perfect start intact before hosting division rival New England in a key AFC East battle next Sunday.
Here is everything you need to know in order to listen to Bills vs. Saints on the radio.
Bills vs. Saints radio station
- National radio channels: SiriusXM channel 227 (home), 382 (away)
- Bills radio channels: WGR 550 AM
- Saints radio channels: WWL (870 AM/105.3 FM)
You can listen to the Bills vs. Saints live on SiriusXM. Coverage will be available on channels 227 (Buffalo Bills) and 382 (New Orleans Saints).
Football fans in the local markets can listen to the game on WGR 550 AM for the Bills and WWL (870 AM/105.3 FM) for the Saints.
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Bills vs. Saints start time
- Date: Sunday, Sep. 28
- Time: 1:00 p.m. ET | 10:00 a.m. PT
Bills vs. Saints will kick off at 1:00 p.m. ET on Sunday, Sep. 28. The game will be played at Highmark Stadium in New York.
Bills 2025 schedule
Here are Buffalo's next five games:
| Date | Matchup | Kickoff time (ET) |
| Sept. 28 | vs. Saints | 1 p.m. |
| Oct. 5 | vs. Patriots | 8:20 p.m. |
| Oct. 13 | at Falcons | 7:15 p.m. |
| BYE | — | — |
| Oct. 26 | at Panthers | 1 p.m. |
| Nov. 2 | vs. Chiefs | 4:25 p.m. |
Saints 2025 schedule
Here are New Orleans' next five games:
| Date | Matchup | Kickoff time (ET) |
| Sept. 28 | at Bills | 1 p.m. |
| Oct. 5 | vs. Giants | 1 p.m. |
| Oct. 12 | vs. Patriots | 4:25 p.m. |
| Oct. 19 | at Bears | 1 p.m. |
| Oct. 26 | vs. Buccaneers | 4:05 p.m. |
NFL schedule 2025: Week 4
Here's a complete look at the NFL schedule for Week 4 of the new season, with games spread out across three days.
Thursday, Sept. 25
| Game | Time (ET) | TV/Live stream |
|---|---|---|
| Cardinals vs. Seahawks | 8:15 p.m. | Prime Video |
Sunday, Sept. 28
| Game | Time (ET) | TV/Live stream |
|---|---|---|
| Steelers vs. Vikings | 9:30 a.m. | Fox, Fubo |
| Falcons vs. Commanders | 1 p.m. | CBS, Fubo |
| Giants vs. Chargers | 1 p.m. | CBS, Fubo |
| Texans vs. Titans | 1 p.m. | CBS, Fubo |
| Buccaneers vs. Eagles | 1 p.m. | Fox, Fubo |
| Patriots vs. Panthers | 1 p.m. | Fox, Fubo |
| Bills vs. Saints | 1 p.m. | CBS, Fubo |
| Lions vs. Browns | 1 p.m. | CBS, Fubo |
| 49ers vs. Jaguars | 4:05 p.m. | Fox, Fubo |
| Rams vs. Colts | 4:05 p.m. | Fox, Fubo |
| Raiders vs. Bears | 4:25 p.m. | CBS, Fubo |
| Chiefs vs. Ravens | 4:25 p.m. | CBS, Fubo |
| Cowboys vs. Packers | 8:20 p.m. | NBC, Fubo, Peacock |
Monday, Sept. 29
| Game | Time (ET) | TV/Live stream |
|---|---|---|
| Dolphins vs. Jets | 7:15 p.m. | ESPN, Fubo |
| Broncos vs. Bengals | 8:15 p.m. | ABC, Fubo |