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49ers vs. Rams live score, updates, highlights from NFL 'Thursday Night Football' game

Jake Mozarsky

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49ers vs. Rams live score, updates, highlights from NFL 'Thursday Night Football' game image

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Week 5 of the 2025 NFL season begins with the San Francisco 49ers making the trip to Inglewood, California, to take on the Los Angeles Rams for "Thursday Night Football."

Both teams enter the game 3-1, but San Francisco is notably beat up. Starting quarterback Brock Purdy is dealing with a toe injury and was expected to be listed as questionable for the contest. Instead, when the final injury report came out on Wednesday, Purdy was ruled out, paving the way for Mac Jones to start another game for the 49ers.

San Francisco's injury report didn't stop there as Ricky Pearsall and Jauan Jennings were also ruled out for the game, leaving the Niners' offense depleted. 

Los Angeles comes into this game off a win over the Indianapolis Colts. Wide receiver Puka Nacua continued his hot start to the season and finished with 170 yards and a touchdown on 13 receptions. Veteran quarterback Matthew Stafford is already up to 1,114 passing yards with eight touchdowns and two interceptions in four games.

Linebacker Byron Young, who leads the Rams and is tied for the overall league lead with five sacks, will look to introduce himself to the San Francisco backfield early and often on Thursday night.

The Sporting News has you covered with LIVE updates, results and highlights from the 49ers-Rams Week 5 "Thursday Night Football" game. 

STREAM: Watch 49ers vs. Rams live with Amazon Prime

49ers vs. Rams score

 

49ers vs. Rams live updates, highlights from Thursday Night Football

9:08 p.m.: Adams has his first reception of the night, with Stafford hitting him on a left-side curl route for 11 yards. The next play, Stafford finds Nacua near the line-to-gain, but a defensive holding makes it an automatic first down.

9:04 p.m.: San Francisco is unable to covert on a 3rd & 5, with Jones trying to hit Bourne but the receiver drops it.

Los Angeles takes over on its own 15-yard line, down 14.

8:57 p.m.: Right when it looks like the Rams are in business, they turn it over. Blake Corum, the second year running back out of Michigan, drops a pitch play, and the 49ers jump on the ball.

San Francisco takes over up 14-0.

8:56 p.m.: Los Angeles now goes for it on a 4th & 9 just ahead of midfield, and it's Williams bringing it up the field to keep the chains moving.

8:53 p.m.: The Rams keep the drive moving, with Stafford hitting Nacua for the second time of the night. This time, it goes for 14 yards.

49ers 14, Rams 0

8:48 p.m. TOUCHDOWN: The 49ers score a touchdown again, and this time, it's Christian McCaffrey.

The running back lined up in the left slot and found himself open on an out-route for a one-yard touchdown. Jones rolled right and found him.

It's the quarterback's second touchdown of the day.

8:47 p.m.: Facing a 3rd & 9, Jones once again connects with a receiver downfield to move the chains. This time, it's Demarcus Robinson, who gets both feet down on the left sideline for an 18-yard completion.

End of the first quarter: 49ers 7, Rams 0

8:43 p.m.: The first quarter was all about the San Francisco offense.

At the end of one, the 49ers are outgaining the Rams 139 to seven and are knocking on the door again. Mac Jones is 9-for-11 for 112 yards and a touchdown.

8:40 p.m.: San Francisco goes for it on fourth down for the second time on the drive, and once again, it converts. A Brian Robinson one-yard carry gets the offense down to the Los Angeles 38.

8:36 p.m.: With the 49ers near midfield, Kyle Shanahan opts to go for it on a 4th & inches. Jones keeps it himself on a quarterback sneak and San Francisco keeps the drive going.

8:29 p.m.: The 49ers get the first sack of the night. Robert Saleh's defense blitzed on second down, and it was Bryce Huff who got to Stafford for a -11 yard sack. 

Los Angeles is unable to convert on third down and the first drive results in a punt.

8:28 p.m.: On second down, Stafford rolls left and hits Nacua for his first reception of the night. After the five-yard reception, Kyren Williams gets his first touch on a two-yard carry, moving the chains.

49ers 7, Rams 0

8:22 p.m. TOUCHDOWN: San Francisco might be without some major weapons, but it didn't stop the 49ers from making a statement in the opening minutes.

On 1st and goal from the Rams 6, Jones finds a wide open Jake Tonges for a touchdown to open the scoring. The quarterback was 5-for-5 for 77 yards and a touchdown on the drive.

8:20 p.m.: Jones' first connection of the night to a player not-named McCaffrey is Kendrick Bourne.

Jones hits Bourne, his former Patriots teammate, on a drag route, and Bourne takes it 35 yards before being brought down right outside of the red zone.

8:18 p.m.: The first three 49ers plays have both ended up in CMC's hands.

After opening up with a short-yardage run, Jones hits McCaffrey on a screen pass and the receiver finds space, turning it upfield for 15 yards.

With a new set of downs, Jones finds McCaffrey underneath again, and the running back picks up a first down for the second straight play. He has two receptions for 30 yards on the first drive of the game.

8:16 p.m.: The Rams have kicked off and we are underway in Los Angeles.

San Francisco will start on offense,

8:10 p.m.: Teams have entered the field and we are moments away from kickoff.

7:50 p.m.: Both quarterbacks are on the field before tonight's contest. Mac Jones is ready for his third start of the season.

Los Angeles' Matthew Stafford is coming off a 375 yards, three touchdown performance against the Colts.

7:28 p.m.: With key offensive pieces out, San Francisco is going to need a big game out of superstar running back Christian McCaffrey.

The 2023 Offensive Player of the Year is yet to have a rushing touchdown this season. He has 225 yards on 69 carries.

7:20 p.m.: We have more stars out at SoFi Stadium, including Ric Flair and LAFC's Son Hueng-Min.

 

Son joined Los Angeles from Tottenham Hotspur before the season. 

7:03 p.m.: The 49ers and Rams have a detailed history, including the regular season finale in 2021. San Francisco was down 14 points and came all the way back to win the game.

The two teams met later that season in the NFC Championship. The Rams, who lost to San Francisco twice in the regular season, won en route to their second Super Bowl title.

6:55 p.m.: It's not "Thursday Night Football" in Los Angeles without celebrities. That includes Kirk Herbstreit's dog, Peter.

Peter, who travels with his owner to all the "Thursday Night Football" and "College GameDay" sets, is a national celebrity. 

6:44 p.m.: ESPN's Adam Schefter has posted the 49ers starting offense for tonight.

San Francisco has posted its inactives for tonight, including Purdy, Jennings, Pearsall and George Kittle. 

6:34 p.m.: We have both former 49ers and Rams on the "Thursday Night Football" crew, and they're not afraid to show it. First, it's Richard Sherman, who played for the 49ers from 2018 to 2020.

On the other side, both Ryan Fitzpatrick and Andrew Whitworth played for the Rams. Whitworth won the Super Bowl in 2021 with Los Angeles, his final game before retiring. 

6:20 p.m.: The Rams have arrived for tonight's game, including star wide receiver Davante Adams.

Adams, the northern California native, has 46 catches for 633 yards and has scored 7 touchdowns in 5 regular games against San Francisco in his career. He has caught a touchdown in every game.

6:05 p.m.: SoFi Stadium is ready for primetime. As usual, Thursday Night Football will be on Prime Video.

Week 4's "Thursday Night Football" broadcast featured the other two NFC West teams with the Seattle Seahawks facing the Arizona Cardinals. Seattle won that contest, 23-20.

5:00 p.m.: San Francisco will be down most of its receiving core with both Ricky Pearsall and Juan Jennings being ruled out. Here are all the active wide receivers for the road team tonight.

4:21 p.m.: Mac Jones has arrived ahead of Thursday Night Football. Jones backed up Brock Purdy on Sunday against the Jacksonville Jaguars, but Purdy was ruled out for tonight's contest earlier in the week.

Jones has 563 yards, four touchdowns and an interception in two starts with San Francisco. The 49ers are 2-0 with Jones as a starter.

NFL HQ: Live NFL scores | Updated NFL standings | Full NFL schedule

Where to watch 49ers vs. Rams tonight

49ers vs Rams start time

  • Date: Thursday, October 2
  • Start time: 8:15 p.m. ET

"Thursday Night Football" between the 49ers and Rams will kick off at 8:15 p.m. ET. The game will be held at SoFi Stadium in Inglewood, California, which means it will begin at 5:15 p.m. PT local time. 

MORE NFL: Ranking the greatest 49ers ever

What channel is 49ers vs. Rams on today?

  • Date: Thursday, October 2
  • TV Channel: None, except local markets
  • Live stream: Amazon Prime

The Week 5 matchup between the 49ers and Rams will primarily be carried on Amazon Prime. It will only air on TV in local San Francisco and Los Angeles markets, and will be on a Fox affiliate in those areas. 

MORE NFL: Who is on the Mount Rushmore of Bay Area sports?

49ers schedule 2025

WeekDateOpponentKickoff time (ET)TV channel
1Sunday, Sept. 7at Seahawks4:05 p.m.Fox
2Sunday, Sept. 14at Saints1 p.m.Fox
3Sunday, Sept. 21vs. Cardinals4:25 p.m.Fox
4Sunday, Sept. 28vs. Jaguars4:05 p.m.Fox
5Thursday, Oct. 2at Rams8:15 p.m.Prime Video
6Sunday, Oct. 12at Buccaneers4:25 p.m.CBS
7Sunday, Oct. 19vs. Falcons8:30 p.m.NBC
8Sunday, Oct. 26at Texans1 p.m.Fox
9Sunday, Nov. 2at Giants1 p.m.CBS
10Sunday, Nov. 9vs. Rams4:25 p.m.Fox
11Sunday, Nov. 16at Cardinals4:05 p.m.Fox
12Monday, Nov. 24vs. Panthers8:15 p.m.ESPN
13Sunday, Nov. 30at Browns1 p.m.CBS
14BYE———
15Sunday, Dec. 14vs. Titans4:25 p.m.Fox
16Monday, Dec. 22at Colts8:15 p.m.ESPN
17Sunday, Dec. 28vs. Bears8:20 p.m.NBC
18TBDvs. SeahawksTBDTBD

MORE NFL: Complete list of Super Bowl MVP winners through the years

Rams schedule 2025

WeekDateOpponentKickoff TimeTV Channel
1Sunday, Sept. 7vs. Texans4:25 p.m.CBS
2Sunday, Sept. 14at Titans1 p.m.CBS
3Sunday, Sept. 21at Eagles1 p.m.Fox
4Sunday, Sept. 28vs. Colts4:05 p.m.Fox
5Thursday, Oct. 2vs. 49ers (TNF)8:15 p.m.Prime Video
6Sunday, Oct. 12at Ravens1 p.m.Fox
7Sunday, Oct. 19vs. Jaguars (London)9:30 a.m.NFL Network
8BYE———
9Sunday, Nov. 2vs. Saints4:05 p.m.Fox
10Sunday, Nov. 9at 49ers4:25 p.m.Fox
11Sunday, Nov. 16vs. Seahawks4:05 p.m.Fox
12Sunday, Nov. 23vs. Buccaneers (SNF)8:20 p.m.NBC
13Sunday, Nov. 30at Panthers1 p.m.Fox
14Sunday, Dec. 7at Cardfinals4:25 p.m.Fox
15Sunday, Dec. 14vs. Lions4:25 p.m.Fox
16Thursday, Dec. 18at Seahawks (TNF)8:15 p.m.Prime Video
17Monday, Dec. 29at Falcons (MNF)8:15 p.m.ESPN
18TBDvs. CardinalsTBDTBD

Jake Mozarsky

Jake Mozarsky joined The Sporting News as an Editorial Intern in August 2025 after earning both his bachelor’s and master’s degrees from Northwestern University. He has previously written for Marquee Sports Network, Chicago This Week, Inside NU and The Daily Northwestern.