It's a next-man-up type game when San Franciso travels to Metlife Stadium for a contest between two teams struck worst by the injury bug last week. The 49ers will be playing on the same turf that they believe is the culprit of all those injuries.
The 49ers (1-1) may have gotten the easy win last week against the Jets, but it really was a losing weekend after both Nick Bosa and Solomon Thomas were lost for the season with ACL tears, and Jimmy Garoppolo and Raheem Mostert sustained injuries that put their playing status in jeopardy. Richard Sherman is still on IR and George Kittle is battling a knee injury sustained in Week 1. Making matters even worse for the reigning NFC champions, the NFC West is arguably the best division in the league this year. The 49ers are the only team with a loss.
Things already were trending downward for the Giants (0-2) before Saquon Barkley tore his ACL and Sterling Shepard aggravated a turf toe injury. Both injuries slow the development of second-year quarterback Daniel Jones who has been just okay this year, throwing for 520 yards, two touchdowns and three picks. Despite the Giants' run defense being one of the worst in the NFL, their pass defense ranks second in yards allowed (377) through a pair of games against Ben Roethlisberger and Mitchell Trubisky.
Dating back to 2014, San Francisco and New York have split the last four times they have played each other. Despite all the injuries to the 49ers' defense, they enter Week 3 as a favorite by about a field goal.
Here's everything you need to know to watch the 49ers vs. Giants game on Sunday, including kickoff time, TV channels and a full Week 3 NFL schedule.
MORE: Watch 49ers vs. Giants live with fuboTV (7-day trial)
What channel is 49ers vs. Giants on today?
- TV channel (national): Fox
- TV channel (San Francisco): KTVU
- TV channel (NYC): WNYW
- Live stream: Fox Sports app, fuboTV
Kevin Burkhardt will be on the call, joined by new partner Daryl Johnston. Pam Oliver will work as sideline reporter with the duo. Former NFL Vice President of Officiating Dean Blandino will float amongst broadcasts to give his analysis of officiating.
For those looking for radio information, the 49ers broadcast can be heard on SiriusXM channel 386, or the Giants broadcast can be heard on SiriusXM channel 227.
In Canada, viewers can watch 49ers vs. Giants on DAZN, which has rights to every NFL game.
49ers vs. Giants start time
- Date: Sunday, Sept. 27
- Kickoff: 1 p.m. ET
49ers vs. Giants is scheduled to start at 1 p.m. ET, one of four regional early games on Fox. Northern California, Oregon and New York City will have access to the game. Other parts of the country will have access to Washington vs. Cleveland, Chicago vs. Atlanta or Los Angeles vs. Buffalo.
MORE: NFL Week 3 TV coverage map
NFL schedule Week 3
Thursday, Sept. 24
| Game | Time (ET) | TV channel |
| Dolphins at Jaguars | 8:20 p.m. | NFL Network, fuboTV |
Sunday, Sept. 27
| Game | Time (ET) | TV channel |
| Bears at Falcons | 1 p.m. | Fox, fuboTV |
| Rams at Bills | 1 p.m. | Fox, fuboTV |
| WFT at Browns | 1 p.m. | Fox, fuboTV |
| Titans at Vikings | 1 p.m. | CBS, fuboTV |
| Raiders at Patriots | 1 p.m. | CBS, fuboTV |
| 49ers at Giants | 1 p.m. | Fox, fuboTV |
| Bengals at Eagles | 1 p.m. | CBS, fuboTV |
| Texans at Steelers | 1 p.m. | CBS, fuboTV |
| Jets at Colts | 4:05 p.m. | CBS, fuboTV |
| Panthers at Chargers | 4:05 p.m. | CBS, fuboTV |
| Lions at Cardinals | 4:25 p.m. | Fox, fuboTV |
| Buccaneers at Broncos | 4:25 p.m. | Fox, fuboTV |
| Cowboys at Seahawks | 4:25 p.m. | Fox, fuboTV |
| Packers at Saints | 8:20 p.m. | NBC, fuboTV |
Monday, Sept. 28
| Game | Time (ET) | TV channel |
| Chiefs at Ravens | 8:15 p.m. | ESPN, fuboTV |
49ers schedule 2020
| Week | Date | Opponent | Kickoff time | TV |
| 1 | Sept. 13 | Cardinals | 4:25 p.m. | FOX |
| 2 | Sept. 20 | @Jets | 1 p.m. | FOX |
| 3 | Sept. 27 | @Giants | 1 p.m. | FOX |
| 4 | Oct. 4 | Eagles | 8:20 p.m. | NBC |
| 5 | Oct. 11 | Dolphins | 4:05 p.m. | FOX |
| 6 | Oct. 18 | Rams | 8:20 p.m. | NBC |
| 7 | Oct. 25 | @Patriots | 4:25 p.m. | CBS |
| 8 | Nov. 1 | @Seahawks | 4:25 p.m. | FOX |
| 9 | Nov. 5 | Packers | 8:20 p.m. | NFL Network |
| 10 | Nov. 15 | @Saints | 4:25 p.m. | FOX |
| 11 | - | BYE | - | - |
| 12 | Nov. 29 | @Rams | 4:05 p.m. | FOX |
| 13 | Dec. 7 | Bills | 4:25 p.m. | FOX |
| 14 | Dec. 13 | Redskins | 4:25 p.m. | FOX |
| 15 | Dec. 20 | @Cowboys | 8:20 p.m. | NBC |
| 16 | Dec. 26 or Dec. 27 | @Cardinals | TBD | TBD |
| 17 | Jan. 3 | Seahawks | 4:25 p.m. | FOX |
Giants schedule 2020
Here is the New York Giants' complete schedule for 2020:
| Week | Date | Opponent | Kickoff time | TV |
| 1 | Sept. 14 | Steelers | 7:15 p.m. | ESPN |
| 2 | Sept. 20 | @Bears | 1 p.m. | Fox |
| 3 | Sept. 27 | 49ers | 1 p.m. | Fox |
| 4 | Oct. 4 | @Rams | 4:05 p.m. | Fox |
| 5 | Oct. 11 | @Cowboys | 4:25 p.m. | Fox |
| 6 | Oct. 18 | Redskins | 1 p.m. | Fox |
| 7 | Oct. 22 | @Eagles | 8:20 p.m. | NFL Network |
| 8 | Nov. 2 | Buccaneers | 8:15 p.m. | ESPN |
| 9 | Nov. 8 | @Redskins | 1 p.m. | Fox |
| 10 | Nov. 15 | Eagles | 1 p.m. | Fox |
| 11 | - | BYE | - | - |
| 12 | Nov. 29 | @Bengals | 1 p.m. | - |
| 13 | Dec. 6 | @Seahawks | 4:05 p.m. | - |
| 14 | Dec. 13 | Cardinals | 1 p.m. | - |
| 15 | Dec. 20 | Browns | 1 p.m. | - |
| 16 | Dec. 27 | @Ravens | 1 p.m. | - |
| 17 | Jan. 3 | Cowboys | 1 p.m. | - |