The 49ers (2-2) will face the Cardinals (4-0) on Sunday at 4:25 p.m. ET at State Farm Stadium in Glendale, Arizona. The game will be televised by FOX.
San Francisco, which is in its fifth season under coach Mike Shanahan, is coming off a 28-21 loss to the Seahawks, the team’s first NFC opponent this season. The 49ers trailed by as many as 14 points in the third quarter and were unable to make a comeback, as they could not build on a late touchdown score in the final two minutes.
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49ers quarterback Jimmy Garoppolo suffered a calf contusion in the first half of that game, forcing backup Trey Lance into the game. Lance completed 9-of-18 passes for 157 yards and two touchdowns and also had seven rushes for 41 yards.
According to Mike Jones of USA TODAY, Lance could start for the 49ers on Sunday, as Garoppolo said previously he could miss multiple weeks of action.
Arizona is arguably the best team in the NFL to this point, defeating the Rams — which beat the defending Super Bowl champion Tampa Bay Buccaneers on Sunday, Sept. 26 — 37-20 last Sunday on the road. The Cardinals have the NFL’s top-ranked scoring offense at 35.0 points per game, and quarterback Kyler Murray is viewed as the betting favorite for the league’s Most Valuable Player award.
Arizona was ranked as the No. 1 squad on NFL.com’s Power Rankings on Tuesday, with Around the NFL writer Dan Hanzus calling the Cardinals’ triumph a “certified, no-doubt-about-it,” kind of win.
Here’s everything you need to know to watch the 49ers vs. Cardinals game on Sunday, including kickoff time, TV channels and a full Week 5 NFL schedule.
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What channel is 49ers vs. Cardinals on today?
- TV channel (national): FOX
- TV channel (San Francisco): KTVU FOX 2
- TV channel (Arizona): FOX 10 Arizona
- Live stream: fuboTV
Play-by-play analyst Chris Meyers will work with analyst Daryl Johnston and field reporter Jennifer Hale for Sunday’s 49ers-Cardinals game.
For those looking for radio information, the 49ers broadcast can be heard on Sirius XM channel 387, or the Cardinals broadcast can be heard on Sirius XM channel 227.
Viewers in Canada can watch the 49ers vs. Cardinals on DAZN, which has rights to every NFL game, as well as some CTV regional channels.
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49ers vs. Cardinals start time
- Date: Wednesday, Oct. 6
- Time: 4:25 p.m. ET
San Francisco vs. Arizona is scheduled to start at 4:25 p.m. ET on Sunday, one of two afternoon games on FOX (Giants vs. Cowboys).
NFL schedule Week 5
Thursday, Oct. 7
| Game | Time (ET) | TV |
| Los Angeles at Seattle | 8:20 p.m. | FOX |
Sunday, Oct. 10
| Game | Time (ET) | TV |
| New York Jets at Atlanta | 9:30 a.m. | NFL Network |
| Detroit at Minnesota | 1 p.m. | FOX |
| New Orleans at Washington | 1 p.m. | CBS |
| New England at Houston | 1 p.m. | CBS |
| Miami at Tampa Bay | 1 p.m. | CBS |
| Green Bay at Cincinnati | 1 p.m. | FOX |
| Denver at Pittsburgh | 1 p.m. | FOX |
| Philadelphia at Carolina | 1 p.m. | FOX |
| Tennessee at Jacksonville | 1 p.m. | CBS |
| Cleveland at Los Angeles Chargers | 4:05 p.m. | CBS |
| Chicago at Las Vegas | 4:05 p.m. | CBS |
| San Francisco at Arizona | 4:25 p.m. | FOX |
| New York Giants at Dallas | 4:25 p.m. | FOX |
| Buffalo at Kansas City | 8:20 p.m. | NBC |
Monday, Oct. 11
| Game | Time (ET) | TV |
| Indianapolis at Baltimore | 8:15 p.m. ET | ESPN |