Reacting to fantasy football Week 1 requires a nuanced approach. Not everything that happens in that first week of action winds up being real, but fantasy players can't ignore everything.
Our experts' Week 2 bold predictions harken back to either Week 1 happenings or react to news that's happened since, with a dash of Week 2 matchup plays tying in.
With this in mind, keep reading to see what we're keeping an eye on for 2025's second fantasy football weekend.
FANTASY WEEK 2 RANKINGS: QB | RB | WR | TE | D/ST | PK | Non-PPR Flex Cheat Sheet
Week 2 Fantasy Football Bold Predictions
Zach Charbonnet continues his takeover of the Seahawks backfield
Kenneth Walker III looked woefully inadequate in Week 1 against the 49ers, managing just 20 yards on 10 carries while Charbonnet amassed 47 yards and a touchdown on 12 carries.
If K9 can’t get it going against Pittsburgh — which just allowed Breece Hall to rack up 145 all-purpose yards on 21 touches — Charbs could take over as Seattle’s bell-cow back as early as the second half of this Week 2 game.
Consider making a trade offer for the 24-year-old now, because the asking price might rise considerably after this weekend in Steel City. - Sloan Piva
Jakobi Meyers will finish as the fantasy WR10 or better
The bolder part of this take is it has zero correlation to the Brock Bowers injury. Now of course if Bowers is hurt, this finish seems more attainable for Meyers.
But even in Week 1, where Bowers played most of the game, Meyers was targeted 10 times. With the way the Chargers looked in Week 1, it’s safe to say Geno Smith will be asked to throw the ball a lot on MNF.
Jakobi Meyers has now played 13 games without Davante Adams in Las Vegas since last season.
— Adam Pfeifer (@APfeifer24) September 10, 2025
The results?
•8.6 targets
•6.2 catches
•74.7 receiving yards
•15.2 PPR PPG
•26.3% target share
Remains the most underrated WR in fantasy football. Pic.twitter.com/93CzDKVUV3
Bowers or not, Meyers is going to be a volume machine in Week 2. - Griffin Missant
FANTASY LINEUP TIPS: Week 2 Start-Sit | Week 2 Sleepers | Week 2 Busts
Jaylen Warren will be a top 10 RB in Week 2
With shades of Chase Brown and Bucky Irving, the Steelers’ change of pace is the workhorse back of choice until they trust rookie Kaleb Johnson.
The Seahawks struggle to cover receivers out of the backfield and Aaron Rodgers will pepper him with checkdowns.
Warren is a good bet to score again and add at least 50 rushing yards to go with his big role in the passing game. - Vinnie Iyer
Braelon Allen will score multiple touchdowns vs. Bills
One of the league's best interior run defenders, Bills lineman Ed Oliver, will miss a few weeks with a foot injury. Even with Oliver in the Week 1, Buffalo struggled to contain Derrick Henry.
This is not saying Allen is anywhere near Henry in terms of skill, and run-first Jets QB Justin Fields could easily accomplish this same feat.
But the Jets will be content in punishing the Bills up the middle and keep the ball out of Josh Allen's hands.
Only FIVE Running Backs w/5+ Carries Registered 1+ Fantasy Points Per Rush in Week 1:
— Sean Mitchell (@smitchell17) September 11, 2025
🥇 (BAL) Derrick Henry (1.49)
🥈 (WAS) BILL Croskey-Merritt (1.42)
🥉 (DEN) RJ Harvey (1.17)
4⃣ (DAL) Javonte Williams (1.16)
5⃣ (NYJ) Braelon Allen (1.15)
Data: @StatRankings
Allen and Breece Hall can coexist as weekly, startable fantasy options, but Allen will again steal the TD spotlight in Week 2. - Tim Heaney
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