There are plenty of matchups you can exploit in Week 6 for fantasy football.
Remember, you should never start a good NFL defense in a bad match, which does not equate to fantasy points. The best way to address the D/ST position is purely based on matchups.
Here are our Week 6 D/ST fantasy football rankings, best starts, sleepers, and some matchups to avoid.
Fantasy Football Defense Rankings Week 6: Who to start, sit at D/ST
Track our weekly fantasy football rankings for every position's lineup tips.
Note: Players who have already had their game are in italicized, strikethrough font.
| Rk | Team Defense | OPP |
| 1 | Green Bay Packers | CIN |
| 2 | Philadelphia Eagles | @NYG |
| 3 | Denver Broncos | NYJ |
| 4 | Buffalo Bills | @ATL |
| 5 | Arizona Cardinals | @IND |
| 6 | Detroit Lions | @KC |
| 7 | New England Patriots | @NO |
| 8 | Pittsburgh Steelers | CLE |
| 9 | San Francisco 49ers | @TB |
| 10 | Washington Commanders | CHI |
| 11 | Cleveland Browns | @PIT |
| 12 | Los Angeles Chargers | @MIA |
| 13 | Tampa Bay Buccaneers | SF |
| 14 | Baltimore Ravens | LAR |
| 15 | Seattle Seahawks | @JAX |
| 16 | Kansas City Chiefs | DET |
| 17 | Los Angeles Rams | @BAL |
| 18 | Indianapolis Colts | ARI |
| 19 | Tennessee Titans | @LV |
| 20 | Las Vegas Raiders | TEN |
| 21 | Dallas Cowboys | @CAR |
| 22 | New York Jets | DEN |
| 23 | Jacksonville Jaguars | SEA |
| 24 | New York Giants | PHI |
| 25 | New Orleans Saints | NE |
| 26 | Chicago Bears | @WAS |
| 27 | Carolina Panthers | DAL |
| 28 | Miami Dolphins | LAC |
| 29 | Atlanta Falcons | BUF |
| 30 | Cincinnati Bengals | @GB |
| BYE | Houston Texans | BYE |
| BYE | Minnesota Vikings | BYE |
Who are the best fantasy defenses in Week 6?
There is zero doubt that the Green Bay Packers' defense will feast on this struggling Bengals team. Cincinnati has scored just 13 total points in the last 2 weeks of football.
Denver also offers a viable start in Week 6. They will travel to London to take on the Jets, who struggled immensely against the Dallas Cowboys' defense and should offer plenty of chances for sacks and takeaways.
ADD THESE D/STs: Waiver Wire Week 6 pickups
Who are the best fantasy defense sleepers in Week 6?
Tennessee has looked bad to start the season, but don't let that deter you from taking advantage of facing a QB who is turning the ball over. In Week 6, the Titans face Geno Smith, who is leading the NFL in thrown interceptions.
Defenses to avoid in fantasy Week 6
The bottom 3 this week are Cincinnati, Atlanta, and Miami. None of them are particularly good, and all have tough matchups vs good offenses.
Even though the Dallas Cowboys looked good defensively against Carolina, there is still no need to start them in Week 6 against Carolina, who saw its offense wake up in Week 5.
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