Seahawks-Cardinals Pick: Betting Prediction, Odds for Thursday Night Football

The NFL action resumes this evening with an NFC West divisional matchup slated for a Thursday night primetime kickoff. Before the battle gets underway, football fans throughout the country can get the best Seahawks-Cardinals betting picks for wagering on the game.

• A devastating injury report for Arizona, featuring star RB James Conner (out for the season) and other key contributors has fueled a massive four-point line swing. The Seahawks, who opened as underdogs, are now 1.5-point road favorites due to heavy sharp money backing them.
• The top betting plays are Seattle -1.5 and the Under 43.5. This strategy bets against Arizona's impressive 6-0 ATS run as an underdog, banking on their injury-depleted offense struggling to score against a Seahawks team that has won seven straight in this series.
• Player props are directly tied to the injury news. The most compelling wagers include Kenneth Walker III Over 52.5 rushing yards, anticipating a run-heavy Seattle game script, and Kyler Murray Under 215.5 passing yards, a fade of the Cardinals' unproven offense.

A pivotal NFC West showdown is on tap as the Seattle Seahawks look to continue their divisional dominance over the Arizona Cardinals. The quarterback matchup features Seattle's Sam Darnold and Arizona's Kyler Murray's, each looking to earn the third win of the young season.

This game presents a classic clash of historical trends and current realities. The Seahawks enter this matchup having won seven consecutive games against the Cardinals, a streak of dominance that has defined this rivalry in recent years.

However, the narrative for this specific contest has been completely reshaped by a devastating string of injuries to Arizona's key offensive players. This has created a "something's gotta give" scenario for bettors, pitting Seattle's head-to-head mastery against Arizona's perfect 6-0 record against the spread in their last six games as an underdog.

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Seahawks-Cardinals Betting Picks

This evening's divisional battle kicks off at 8:15 pm ET, from the climate-controlled State Farm Stadium in Glendale, Arizona. The Seahawks enter this contest with a high-powered offense, averaging a robust 29.3 points and 315.0 total yards per game. Their efficiency near the goal line has been a major factor, converting on 63.6% of their red zone attempts.

In contrast, the Cardinals have put up 20.0 points per game on 276.3 yards of offense. While the Cardinals' offense has been remarkably careful with the football—committing just one turnover on the season—they have been less effective in scoring situations with a 50.0% red zone conversion rate. Defensively, Seattle has been more opportunistic, collecting five interceptions to Arizona's two, setting the stage for a classic battle of offensive firepower against a more ball-secure, yet less explosive, opponent.

Seahawks vs. Cardinals Betting Odds

The NFL betting lines point to a tightly contested game, with the Seahawks installed as slight 1.5-point road favorites. The (-125) moneyline for Seattle implies a 55.6% chance of victory, while the Cardinals' (+105) odds suggest a 48.8% chance. After removing the sportsbook's vig, the normalized probabilities show the Seahawks at approximately 53.2% and the Cardinals at 46.8%.

Bettors are faced with compelling but conflicting trends. The Cardinals have been a covering machine as underdogs, going a perfect 6-0 against the spread (ATS) in their last six games in that role. Conversely, the Seahawks have dominated this head-to-head series, posting a 6-1 ATS record against Arizona over their last seven meetings and winning seven straight outright. Seattle has also excelled as a favorite, going 7-1 in their last eight games when favored.

The total for this matchup has seen significant movement, opening at 46.5 before dropping to 43.5. This shift suggests early money favored the under, a trend supported by history, as the under has hit in three of the last four games between these two teams. While Arizona has seen the over hit in its last four home games, the Cardinals have also gone under the total in eight of their last nine games as an underdog.

Seahawks vs. Cardinals Odds Movement & Analysis

The betting market for Thursday Night Football has undergone a dramatic transformation since lines opened, indicating a significant shift in sentiment and likely some heavy-hitting wagers. This game opened with the Arizona Cardinals as (-2.5) point home favorites, but the line has completely flipped.

Spread Movement: The most significant shift occurred on the point spread, which has swung a full four points. After opening with the Cardinals favored by 2.5 points, the line now lists the Seahawks as 1.5-point road favorites. This indicates substantial and respected money has come in on Seattle, enough to move the line through the key number of zero and establish them as the favorite.

Moneyline Flip: The moneyline tells the same story. Arizona opened as a clear (-141) favorite, while Seattle was a (+115) underdog. The market has completely reversed, with the Seahawks now sitting at (-125) and the Cardinals relegated to (+105) underdog status.

Total Points Drop: The game total has also seen major movement, opening at 46.5 before plummeting three full points to 43.5. This sharp decline suggests early bettors are anticipating a lower-scoring affair, a belief supported by the fact that the under has hit in eight of Arizona's last nine games as an underdog.

This movement appears to be driven by market action rather than external factors. With the game being played inside State Farm Stadium, weather is not a consideration. The reversal suggests that bettors are weighing Seattle's historical dominance in this matchup—winning seven straight and going 6-1 ATS against the Cardinals in their last seven meetings—more heavily than Arizona's recent success as an underdog, where they are a perfect 6-0 ATS in their last six tries.

For bettors, the initial value on Seattle has evaporated. The strategic focus now shifts to those who still favor the Seahawks, who must lay points on the road, a position where they have struggled to cover recently, going 0-3-2 ATS in their last five road games as a favorite. The value may now lie with the contrarian play: taking the Cardinals (+1.5) at home, allowing you to back their impressive underdog trend and capitalize on a line that has moved significantly in your favor.

Seahawks vs. Cardinals Injury Report

Both NFL teams enter this divisional matchup with lengthy injury reports, but the Cardinals are facing more significant and potentially game-altering concerns. The health of key offensive players for Arizona could be the deciding factor and helps explain the dramatic line movement in Seattle's favor.

Seattle Seahawks

The Seahawks have 11 players on their report, but many key contributors were able to practice in a limited or full capacity, offering hope for their availability.

Arizona Cardinals

The Cardinals' injury situation is far more precarious, with multiple offensive starters failing to practice early in the week. James Conner was lost to a season ending foot injury, forcing the Cardinals running back depth to step up on a short week.

On top of Conner being out, the potential absence of several offensive linemen would severely hamstring the Arizona offense, which already averages nearly 10 points fewer per game than Seattle.

This makes the Under 43.5 an increasingly compelling wager, as Arizona may struggle to put up points. The injuries provide clear context for why the betting line has swung four full points in Seattle's favor.

Seahawks vs. Cardinals – Key Matchups to Watch

The outcome of this NFC West matchup will likely be decided in the trenches and by which team can best exploit the other's injury-related weaknesses. While Seattle boasts a potent offense, the Cardinals' precarious health situation creates several glaring mismatches that could dictate the flow of the game.

Darnold vs. Cardinals Pass Defense

This matchup pits Seattle's efficient passing game against a Cardinals secondary that could be missing key personnel. Darnold pilots an offense that has been effective, contributing to the team's average of 29.3 points per game. Seattle has proven they can finish drives, a stark contrast to their opponent.

The Cardinals' pass defense has generated two interceptions this season, showing a degree of opportunism. However, their ability to consistently disrupt opposing quarterbacks is a major question mark, particularly with starting cornerback Will Johnson listed as "Did Not Participate" on the injury report.

His potential absence would create a significant vulnerability for Seattle's receivers to exploit. For Arizona to succeed, their pass rush must find a way to pressure Darnold and prevent him from finding favorable matchups against a potentially depleted secondary.

Seahawks Running Game vs. Cardinals Run Defense

Seattle's backfield duo of Kenneth Walker III and Zach Charbonnet enters this game with a decisive advantage, especially in the red zone. The Seahawks have been clinical near the goal line, converting on a robust 63.6% of their red zone trips into touchdowns. Charbonnet's full participation in practice signals the 1-2 punch is at full strength and ready to test Arizona's defensive front.

The Cardinals' run defense faces a monumental task, and the real story is on the other side of the ball. Arizona's offense will need to find a new way to run the football as Conner has been lost for the season due to a foot injury, a devastating blow. His absence cripples Arizona's ground attack and removes their most reliable weapon in the red zone, where the team already struggles with a 50.0% conversion rate.

Seahawks Pass Catchers vs. Cardinals Secondary

This is arguably the most significant mismatch of the game. The Seahawks feature a talented receiving corps led by Jaxon Smith-Njigba complemented by veteran Cooper Kupp. This duo presents a formidable challenge for any secondary, let alone one that may be shorthanded.

Arizona's defensive backfield is already under fire, with CB Johnson's availability in serious doubt. If he is unable to go, the Cardinals will have to find an answer for Seattle's weapons with backup players, creating a scenario ripe for big plays.

Seahawks Defensive Line vs. Cardinals Offensive Line

The battle in the trenches heavily favors Seattle. The Cardinals' injury report is a disaster for their offensive line, with starting tackle Paris Johnson Jr. listed as questionable and three other linemen also on the report. This unit was already facing a tough test, and its compromised state is a major liability.

Seattle's pass rush, featuring defensive end Leonard Williams and linebacker Boye Mafe, must be salivating. Although both are dealing with injuries, their presence creates enormous problems for a patched-up Arizona front.

If Williams and Mafe can consistently win their one-on-one matchups, they can disrupt the Cardinals' offense at its source, generating pressure, forcing turnovers, and shutting down an attack that is already missing its most important playmakers. This matchup advantage for the Seattle defense is a primary driver behind the massive four-point line swing in their favor.

Seahawks vs. Cardinals Passing Props

The passing game props for this matchup reflect the overall game narrative: a relatively low total and significant questions surrounding the health of the Arizona offense. Both quarterbacks have similar yardage props, but the context surrounding them suggests very different potential outcomes.

Prop Analysis

Sam Darnold (SEA)

Darnold's passing line is set at a modest 219.5 yards. While Seattle's offense has been potent, averaging 29.3 points per game, the heavily juiced Under 1.5 Passing TDs (-200) suggests the market expects the Seahawks to do their damage on the ground, aligning with their strong red zone efficiency. The most intriguing angle for Darnold might be attacking the over on his yardage.

The Cardinals' secondary has managed just two interceptions all season and could be without starting cornerback Johnson, who is listed as doubtful for tonight's contest. This creates a potential mismatch for Seattle's receivers and could allow Darnold to comfortably surpass his yardage total, even if he isn't throwing for touchdowns.

Kyler Murray (ARI)

The deck appears stacked against Murray. His passing yardage line of 215.5 seems high given the circumstances. He'll be operating behind an offensive line with four players on the injury report. This is a recipe for disaster against a Seahawks defense that has already collected five interceptions this season and features a pass rush duo of Williams and Mafe.

With his top weapons sidelined and pressure likely coming early and often, the Under 215.5 passing yards (-115) is a compelling play. The Over 0.5 Interceptions (-111) also holds significant appeal, as Murray will be forced to make difficult throws under duress.

Best Bet: Murray Under 215.5 Passing Yards (-115)

The combination of significant injuries to his top playmakers and a compromised offensive line facing an opportunistic Seattle defense makes it difficult to project a productive day for Murray. The Cardinals' offense already averages just 276.3 total yards per game, and without its key pieces, staying under this number feels like the most probable outcome.

Seahawks vs. Cardinals Rushing & Receiving Props

The player prop market for this game is heavily influenced by the significant injuries on the Arizona side, creating clear opportunities for bettors. The lines for Seattle's playmakers suggest a positive game script, while the props for Arizona's skill players point to a challenging offensive day.

Prop Analysis

Kenneth Walker III (SEA)

Walker's rushing line of 52.5 yards appears to be one of the most attackable props on the board. With the Cardinals' offense severely compromised by injuries to James Conner, Zay Jones, and the offensive line, the Seahawks are positioned for a favorable game script that should feature a heavy dose of the run.

Seattle boasts a 63.6% red zone conversion rate, and feeding their top back is a key part of that success. Against a potentially demoralized defense that will spend a lot of time on the field, Walker is in a prime position to exceed this modest total. His Anytime TD prop at (+105) also offers excellent value.

Trey Benson & the Arizona Backfield

With Conner out for the season, the props indicate  Benson will step into the lead role. His rushing line is set at 59.5 yards. However, he faces a tough task against a Seattle front seven that knows Arizona's offense is one-dimensional.

The Seahawks' defense has already forced 5 interceptions and will likely focus on stopping the run to make Murray beat them with a depleted receiving corps. This sets up a difficult environment for Benson to find running lanes, making the Under 59.5 Rushing Yards (-118) a logical play.

Jaxon Smith-Njigba (SEA) & McBride (ARI)

This matchup highlights two receivers poised for big volume for different reasons. Smith-Njigba's receiving line of 82.5 yards is a direct reflection of the potential absence of Cardinals starting CB Johnson. This creates a significant mismatch that Sam Darnold and the Seattle offense will likely exploit early and often.

For the Cardinals, McBride is set to be Murray's primary target. With Marvin Harrison Jr. off to a slow start and Zay Jones in the concussion protocol, McBride's role as the safety blanket and go-to receiver elevates significantly. His receptions line of 6.5 (O -115) is a testament to this expected volume. Against a Seahawks pass rush that will be hunting a banged-up offensive line, expect Murray to look for McBride on quick, high-percentage throws, making the over on his receptions a strong consideration.

Best Bet: Kenneth Walker III Over 52.5 Rushing Yards (-114)

Everything points to a run-heavy game plan for Seattle. The injuries to Arizona's offense, combined with Seattle's efficiency and historical dominance in this series, suggest the Seahawks will look to control the clock and pound the rock. Walker is the primary beneficiary of this game script, and 52.5 yards is a low bar for a lead back to clear in what should be a favorable matchup.

Seahawks vs. Cardinals Picks & Prediction

Our fearless forecast centers on a narrative of dominance meeting desperation, where Seattle's arsenal bulldozes through Arizona's injury-riddled roster. This divisional battle has been defined by a dramatic four-point line swing, and for good reason.

The injury report tells the entire story, painting a grim picture for an Arizona team that is now a home underdog. While the Cardinals have been an incredible bet as an underdog, going a perfect 6-0 ATS in their last six opportunities, the sheer volume of injuries to key offensive players is too much to overcome. The Seahawks have won seven straight against Arizona and are 6-1 ATS in their last seven meetings, a trend that is poised to continue.

The decisive factor is the catastrophic state of the Arizona offense. Murray faces a nightmarish scenario: he'll be without his starting running back (Conner) and will potentially be playing behind an offensive line with four players on the injury report. This is a recipe for disaster against a Seattle defensive front featuring Williams and Mafe.

The Seahawks' defense has already forced five interceptions this season and will be able to pin its ears back, knowing the Cardinals lack the weapons to make them pay. Conversely, Darnold pilots an offense averaging 29.3 points per game against a Cardinals secondary that may be without starting corner Will Johnson. Seattle's offensive efficiency, particularly its 63.6% red zone conversion rate, provides multiple paths to victory.

With the game in a climate-controlled stadium, weather is a non-issue. The game plan for Seattle seems clear: control the clock with Walker and Charbonnet, and let Darnold pick apart a wounded secondary. This methodical approach, combined with Arizona's offensive struggles, makes the total a compelling play. The under has hit in eight of the Cardinals' last nine games as an underdog, and there's little reason to believe their depleted offense can do its part to push this game over the total.

Against the Spread (ATS) Pick: Seahawks -1.5 (-110)

Trust the matchup, not the trend. Arizona's 6-0 ATS run as an underdog is impressive, but it runs headlong into a Seattle team that is healthier, more talented, and has historically owned this series. The injuries to Conner, Jones, and the offensive line cripple the Cardinals' ability to compete. Lay the small number with the superior team.

Over/Under Pick: Under 43.5 (-110)

This is the strongest play on the board. The Cardinals' offense, which averages just 20.0 points per game at full strength, will be lucky to score half that given the injuries. The Seahawks will likely lean on their run game to control the tempo, bleeding the clock and limiting total possessions. This aligns perfectly with the trend of the under hitting in eight of Arizona's last nine games as an underdog.

Best Prop Bet: Walker III Over 52.5 Rushing Yards (-114)

A positive game script for Seattle means a heavy dose of the run. With the Seahawks expected to play with a lead, Walker will be called upon to wear down the Arizona defense and salt away the clock. This line is simply too low for a lead back in such a favorable situation.

Same-Game Parlay Idea:

• Seahawks Moneyline (-125)
• Under 43.5 Total Points (-110)
• Kenneth Walker III 40+ Rushing Yards (Alt Line)

This parlay combines the most likely outcomes: a Seattle win in a lower-scoring, grind-it-out game where their lead back handles a significant workload.

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Public Betting Splits

The public and sharp money have spoken, and they are largely in agreement on the side but divided on the total. The betting splits reveal overwhelming professional confidence in the Seahawks, which directly explains the dramatic four-point line swing in their favor.

Against the Spread: The action on the spread is about as one-sided as it gets. A staggering 96.06% of the money is backing the Seahawks (-1.5), even though that side has only attracted 85.91% of the total bets. This indicates that while the public is heavily on Seattle, the largest, most respected wagers are pounding the Seahawks, providing clear evidence that sharp money drove the line from ARI (-2.5) to SEA (-1.5).

Moneyline: The moneyline shows a more defined split between sharps and the public. While bets are nearly split down the middle (52.81% on Seattle, 47.19% on Arizona), the money tells a different story. A commanding 86.7% of the handle is on the Seahawks moneyline, compared to just 13.3% on the Cardinals. This is a classic indicator of professional bettors backing the favorite to win outright, while smaller, public bets are taking a shot on the plus-money home underdog.

Game Total (Over/Under): The total reveals the most significant disagreement. The majority of bets (55.93%) are on the Under 43.5, aligning with the line dropping three full points. However, the sharp money is pushing back against this trend, with 62.61% of the handle placed on the Over. This suggests that while the public is reacting to Arizona's injuries and trends, sharps believe the market has overcorrected and are "buying low" on the Over at the new number of 43.5.