Although favorites held strong in Week 6, sporting a 9-5 ATS mark ahead of Monday night's Chargers-Cowboys tilt, we saw two (and nearly three) shocking upsets. Thanks to some late-game miscues, the 49ers' and Eagles' undefeated seasons came to a halt against two of the league's most complete defenses, the Browns and Jets.
In Sunday's nightcap, the Giants (+15.5) closed as the largest point-spread underdog of the season and were one yard short of notching a monumental upset in Orchard Park. Thankfully for Bills in-game and second-half bettors -- as well as those who had Buffalo in survivor pools -- you made it out by the skin of your teeth. This past week was yet another reminder that anything can happen on any given week of the NFL season.
Looking towards the Week 7 slate, the action kicks off with what should be a competitive matchup on Thursday Night Football, when the Saints (-1) host the Jaguars. The slate is condensed to 13 games with six teams on bye, but there are still several intriguing matchups, most notably the Ravens-Lions, Chiefs-Chargers, and Eagles-Dolphins.
Below, we'll look at the latest odds for Week 7 from BetMGM and offer up a couple of early bets to consider. Keep in mind these lines will move throughout the week as we get updates on the playing status of key starters and betting limits increase.
NFL odds Week 7
Odds courtesy of BetMGM
| Game | Spread |
| New Orleans Saints vs. Jacksonville Jaguars | NO -1 (-110) |
| Chicago Bears vs. Las Vegas Raiders | CHI +3 (-105) |
| Indianapolis Colts vs. Cleveland Browns | IND +1.5 (-110) |
| New England Patriots vs. Buffalo Bills | NE +8.5 (-110) |
| New York Giants vs. Washington Commanders | NYG +1.5 (-105) |
| Tampa Bay Buccaneers vs. Atlanta Falcons | TB -2.5 (-110) |
| Baltimore Ravens vs. Detroit Lions | BAL -3 (-110) |
| Los Angeles Rams vs. Pittsburgh Steelers | LAR -3 (-115) |
| Seattle Seahawks vs. Arizona Cardinals | SEA -7.5 (-110) |
| Denver Broncos vs. Green Bay Packers | DEN +1 (-110) |
| Kansas City Chiefs vs. Los Angeles Chargers | KC -5.5 (-120) |
| Philadelphia Eagles vs. Miami Dolphins | PHI -2 (-110) |
| Minnesota Vikings vs. San Francisco 49ers | MIN +6.5 (-105) |
NFL moneylines Week 7
| Game | Moneyline |
| New Orleans Saints vs. Jacksonville Jaguars | NO -120 | JAX +100 |
| Chicago Bears vs. Las Vegas Raiders | LV -160 | CHI +135 |
| Indianapolis Colts vs. Cleveland Browns | CLE -120 | IND +100 |
| New England Patriots vs. Buffalo Bills | BUF -400 | NE +310 |
| New York Giants vs. Washington Commanders | WAS -130 | NYG +110 |
| Tampa Bay Buccaneers vs. Atlanta Falcons | TB -145 | ATL +120 |
| Baltimore Ravens vs. Detroit Lions | BAL -155 | DET +135 |
| Los Angeles Rams vs. Pittsburgh Steelers | LAR -175 | PIT +145 |
| Seattle Seahawks vs. Arizona Cardinals | SEA -375 | ARI +290 |
| Denver Broncos vs. Green Bay Packers | GB -115 | DEN -105 |
| Kansas City Chiefs vs. Los Angeles Chargers | KC -250 | LAC +190 |
| Philadelphia Eagles vs. Miami Dolphins | PHI -130 | MIA +110 |
| Minnesota Vikings vs. San Francisco 49ers | SF -300 | MIN +240 |
NFL over/unders Week 7
| Game | Over/Under |
| New Orleans Saints vs. Jacksonville Jaguars | 40 |
| Chicago Bears vs. Las Vegas Raiders | 37.5 |
| Indianapolis Colts vs. Cleveland Browns | 39 |
| New England Patriots vs. Buffalo Bills | 41.5 |
| New York Giants vs. Washington Commanders | 39.5 |
| Tampa Bay Buccaneers vs. Atlanta Falcons | 38 |
| Baltimore Ravens vs. Detroit Lions | 42 |
| Los Angeles Rams vs. Pittsburgh Steelers | 44 |
| Seattle Seahawks vs. Arizona Cardinals | 44.5 |
| Denver Broncos vs. Green Bay Packers | 45 |
| Kansas City Chiefs vs. Los Angeles Chargers | 47.5 |
| Philadelphia Eagles vs. Miami Dolphins | 52 |
| Minnesota Vikings vs. San Francisco 49ers | 44 |
NFL best bets for Week 7
*Odds and analysis as of Monday 10/16*
Browns -1.5 (-115) @ Colts
Cleveland will likely be a popular public side this week, but we'll still lay this short number to back the league's most efficient defense. There's a chance Deshaun Watson (shoulder) returns this week, and while he hasn't been that impressive in his time with Cleveland, he's undoubtedly an upgrade from backup P.J. Walker. We don't think the Gardner Minshew-led Colts will generate enough scoring drives to notch the home win.
Rams-Steelers UNDER 43.5 (-110)
With Matt Canada still calling the plays for the Steelers offense, we'll gladly bet the UNDER 43.5 in what's probably a low-scoring game won by whichever team wins the turnover battle. We've seen Pittsburgh's defense singlehandedly win games this season, and although the Rams offense is an above-average unit, Pittsburgh's pass rush should give Matthew Stafford and company some problems. We'd be fine with a 23-20 final here.