To juice up an already exciting Thanksgiving weekend, all 32 teams are in action for a loaded 16-game Week 12 slate. The action gets underway with three Thanksgiving day tilts (Lions-Packers, Cowboys-Commanders, and Seahawks-49ers) before the league's first-ever Black Friday matchup featuring the Dolphins and Jets.
Sunday's 11-game slate should lend itself to plenty of high-intensity moments, with 10 games priced with spreads less than a touchdown. That's a recipe for some nail-biting finishes, which should be a perfect end to the holiday weekend. To make things even sweeter, a profitable NFL betting weekend is the perfect way to cap off the holiday.
Below, we'll look at the latest odds for Week 12 from Caesars Sportsbook and offer up a couple of early bets to consider. Keep in mind these lines will move throughout the week as we get updates on the playing status of key starters and betting limits increase.
NFL odds Week 12
Odds courtesy of Caesars Sportsbook
| Game | Spread |
| Detroit Lions vs. Green Bay Packers | DET -7.5 (-105) |
| Dallas Cowboys vs. Washington Commanders | DAL -12 (-110) |
| Seattle Seahawks vs. San Francisco 49ers | SEA +7 (-110) |
| New York Jets vs. Miami Dolphins | NYJ +10 (-110) |
| New York Giants vs. New England Patriots | NYG +3 (+105) |
| Indianapolis Colts vs. Tampa Bay Buccaneers | IND -2.5 (-110) |
| Atlanta Falcons vs. New Orleans Saints | ATL PK (-110) |
| Cincinnati Bengals vs. Pittsburgh Steelers | CIN +1 (-110) |
| Tennessee Titans vs. Carolina Panthers | TEN -3.5 (-110) |
| Houston Texans vs. Jacksonville Jaguars | HOU +1.5 (-110) |
| Arizona Cardinals vs. Los Angeles Rams | ARI PK (-110) |
| Denver Broncos vs. Cleveland Browns | DEN PK (-110) |
| Philadelphia Eagles vs. Buffalo Bills | PHI -3 (-120) |
| Las Vegas Raiders vs. Kansas City Chiefs | LV +9 (-110) |
| Los Angeles Chargers vs. Baltimore Ravens | LAC +3.5 (-110) |
| Minnesota Vikings vs. Chicago Bears | MIN -3.5 (-105) |
NFL moneylines Week 12
| Game | Moneyline |
| Detroit Lions vs. Green Bay Packers | DET -365 | GB +285 |
| Dallas Cowboys vs. Washington Commanders | DAL -700 | WAS +500 |
| Seattle Seahawks vs. San Francisco 49ers | SF -350 | SEA +275 |
| New York Jets vs. Miami Dolphins | MIA -480 | NYJ +360 |
| New York Giants vs. New England Patriots | NE -160 | NYG +135 |
| Indianapolis Colts vs. Tampa Bay Buccaneers | IND -140 | TB +118 |
| Atlanta Falcons vs. New Orleans Saints | ATL -110 | NO -110 |
| Cincinnati Bengals vs. Pittsburgh Steelers | PIT -115 | CIN -105 |
| Tennessee Titans vs. Carolina Panthers | TEN -190 | CAR +158 |
| Houston Texans vs. Jacksonville Jaguars | JAX -130 | HOU +110 |
| Arizona Cardinals vs. Los Angeles Rams | LAR -115 | ARI -105 |
| Denver Broncos vs. Cleveland Browns | DEN -110 | CLE -110 |
| Philadelphia Eagles vs. Buffalo Bills | PHI -170 | BUF +143 |
| Las Vegas Raiders vs. Kansas City Chiefs | KC -430 | LV +328 |
| Los Angeles Chargers vs. Baltimore Ravens | BAL -190 | LAC +158 |
| Minnesota Vikings vs. Chicago Bears | MIN -178 | CHI +150 |
NFL over/unders Week 12
| Game | Over/Under |
| Detroit Lions vs. Green Bay Packers | 47 |
| Dallas Cowboys vs. Washington Commanders | 48.5 |
| Seattle Seahawks vs. San Francisco 49ers | 44 |
| New York Jets vs. Miami Dolphins | 41.5 |
| New York Giants vs. New England Patriots | 33.5 |
| Indianapolis Colts vs. Tampa Bay Buccaneers | 44 |
| Atlanta Falcons vs. New Orleans Saints | 42 |
| Cincinnati Bengals vs. Pittsburgh Steelers | 34.5 |
| Tennessee Titans vs. Carolina Panthers | 37 |
| Houston Texans vs. Jacksonville Jaguars | 48.5 |
| Arizona Cardinals vs. Los Angeles Rams | 44.5 |
| Denver Broncos vs. Cleveland Browns | 35 |
| Philadelphia Eagles vs. Buffalo Bills | 48.5 |
| Las Vegas Raiders vs. Kansas City Chiefs | 43 |
| Los Angeles Chargers vs. Baltimore Ravens | 47 |
| Minnesota Vikings vs. Chicago Bears | 43 |
NFL best bets for Week 12
*Odds and analysis as of Monday 11/20*
Steelers -1 (-110) @ Bengals
This game isn't going to be pretty, just like every Steelers game this season, but if Mike Tomlin and company can't beat the Joe Burrow-less Bengals, then I'll officially waive the white flag on this season. Pittsburgh's offense still can't do much of anything right now, but there's no excuse not to take advantage of a reeling Bengals bunch.
Chargers +4 (-110) vs. Ravens
I'll take a contrarian stance and back the Chargers to stay within the number at home on Sunday night. What else is new? The Chargers are coming off a one-score loss, and while they don't have to win outright for us to cash our ticket, L.A. tends to play close games when they step up in class.