Phillies vs. Brewers Odds, Picks, Predictions (Sept. 1)

Two division leaders begin a series in Milwaukee on Monday. Read this Phillies-Brewers betting preview to view odds, trends and sportsbook bonuses.

• The Milwaukee Brewers send high-strikeout prospect Jacob Misiorowski to the mound against the Philadelphia Phillies and veteran Taijuan Walker.
• Milwaukee has dominated this head-to-head matchup recently, winning the last four meetings between the clubs.
• Christian Yelich has exceptional career numbers against Walker, boasting a 2.400 OPS in five at-bats, making his player props particularly noteworthy.

The Brewers, behind their hard-throwing young arm Jacob Misiorowski (4-2, 4.33 ERA), look to open their series against the visiting Phillies with a victory. Misiorowski, known for his elite strikeout potential, faces a formidable challenge in a Phillies lineup that lives and dies by the long ball. Philadelphia counters with veteran right-hander Taijuan Walker (4-7, 3.63 ERA), who has struggled to find consistency this season and has historically been roughed up by the current Brewers roster.

This matchup presents a classic clash of styles. The Brewers combine contact, speed, and aggressive baserunning to manufacture runs, while the Phillies deploy a power-heavy, all-or-nothing offensive approach. With both teams in the thick of the playoff hunt, this series opener carries significant weight as September baseball gets underway. 

First pitch is scheduled for 4:10 pm ET at American Family Field in Milwaukee. Below, we look at MLB betting odds from DraftKings Sportsbook.

Brewers vs. Phillies Betting Odds

Odds as of Sep 1, 2025 on DraftKings.

The odds favor the Brewers at home, a reflection of their strong record at home and the favorable pitching matchup. The moneyline implies a significant edge for Milwaukee.

Odds Movement & Analysis

The betting market has shown subtle but telling movement. The Brewers opened as -164 favorites, but the line has shifted slightly to -158, indicating some money has come in on the underdog Phillies. This movement runs contrary to public betting splits, which show over 75% of moneyline tickets on the Brewers, suggesting potential sharp action on Philadelphia.

The total opened at 8.5 runs and has been bet up to a flat 9.0, with over 80% of the public backing the Over. This move is likely driven by Walker's recent struggles, Misiorowski's volatility, and injuries to key bullpen arms on both sides.

The Phillies are without closer Jordan Romano and ace Zack Wheeler, while the Brewers' relief corps is also banged up, creating a scenario where late-inning runs could be plentiful. The current lines may offer value on the Brewers' run line, as the +133 price is more attractive than the opening +128 despite the heavy public backing.

Brewers vs. Phillies Batter Props

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MLB batter props as of Sep 1, 2025 from DraftKings.

Pitcher Props

MLB pitcher props as of Sep 1, 2025 from DraftKings.

The prop market offers several intriguing angles. For the Brewers, Christian Yelich's total bases prop of 1.5 at +120 odds is highly appealing. He is 4-for-5 with a home run and a double in his career against Taijuan Walker, translating to an absurd 2.400 OPS. Given this history, he has a clear path to exceeding this number.

On the pitching side, Misiorowski's strikeout prop is set at 6.5. While the Phillies have a potent offense, they also strike out frequently. With Misiorowski's elite swing-and-miss stuff, the Over at +110 presents solid value, especially if he can maintain his command for five innings. For Taijuan Walker, the Over 2.5 earned runs (-130) seems likely, considering his recent form (9 ER in 16.2 IP) and the Brewers' collective success against him.

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Brewers vs. Phillies Final Prediction

The Brewers are well-positioned to take the series opener, primarily due to the significant pitching mismatch. Walker has not only struggled recently but has been historically ineffective against this Brewers lineup. Key hitters like  Yelich, Chourio, and Turang have all had success against him in the past.

Walker's tendency to surrender hard contact aligns poorly with a Brewers team that excels at putting the ball in play and using their speed to create scoring chances. On the other side, Misiorowski is a high-variance pitcher, but his strikeout ability is the perfect antidote to a Phillies offense that ranks among the league leaders in both home runs and strikeouts. If he can limit his walks, he has the arsenal to mow down the Phillies' top power threats.

Several MLB betting trends strongly support a Milwaukee victory. The Brewers are an incredible 9-1 in their last 10 home games against teams with a winning record and have gone 15-5 after a loss over their last 20 contests. Furthermore, they have won their last four games against the Phillies, showcasing a clear head-to-head advantage.

Conversely, the Phillies are just 1-4 in their last five road games. With both bullpens depleted by injuries, runs could come in bunches, especially late. The Brewers' offense should do enough damage against Walker to build an early lead, and their stellar home record makes them a confident pick.

Picks:

• Milwaukee Brewers Moneyline (-158)
• Milwaukee Brewers -1.5 Run Line (+133)
• Over 9 Runs (-106)

Public Betting Splits

The public is heavily favoring the Brewers on both the moneyline and the run line, as well as the Over on the total. This overwhelming support aligns with our analysis, suggesting that the pitching matchup and recent team trends are clear indicators for most bettors.

While it's often wise to be wary of such lopsided public action, the underlying data in this specific matchup strongly supports the popular plays.