The Week 6 edition of Thursday Night Football features an NFC East showdown as the defending Super Bowl champion Philadelphia Eagles visit the New York Giants.
Saquon Barkley returns to his old stomping grounds in MetLife Stadium once again, and he looks to be cleared of an early-week knee injury.
Which other Eagles and Giants should you consider starting in your fantasy football matchups?
Continue scrolling for our full breakdown of TNF Week 6 fantasy tips.
Week 6 TNF Start-Sit: Eagles vs. Giants Lineup Picks
Click to read Vinnie Iyer's full Week 6 Start 'Em Sit 'Em fantasy tips.
TNF Week 6 Must-Start Players
- QB Jalen Hurts, Eagles
- RB Saquon Barkley, Eagles
- WR A.J. Brown, Eagles
- WR DeVonta Smith, Eagles
- TE Dallas Goedert, Eagles
- Eagles D/ST
Start 'Em TNF Week 6
- RB Cam Skattebo, Giants
Sit 'Em TNF Week 6
- WR Wan'Dale Robinson, Giants
Week 6 TNF fantasy rankings by position
Note: Weekly fantasy rankings were last updated Wednesday at 5 p.m. ET.
QB Week 6 TNF rankings
- Jalen Hurts QB2
- Jaxson Dart QB24
RB Week 6 TNF rankings (PPR)
- Saquon Barkley RB13
- Cam Skattebo RB17
- Tyrone Tracy RB35
- Will Shipley/AJ Dillon Bench
WR Week 6 TNF rankings (PPR)
- DeVonta Smith WR15
- A.J. Brown WR25
- Wan'Dale Robinson WR40
TE Week 6 TNF rankings (PPR)
- Dallas Goedert TE9
- Theo Johnson TE17
D/ST Week 6 rankings
- Philadelphia Eagles DST2
- New York Giants DST24
PK Week 6 rankings
- Jake Elliott PK4
- Jude McAtamney PK26
Click to see the full Half-PPR Week 6 flex fantasy rankings if you're playing in those formats.
NFL DFS Week 6 TNF Perfect Lineups
Read Sloan Piva's full TNF Week 6 NFL DFS strategy.
DraftKings TNF Week 6 Showdown Optimal NFL DFS Lineup
| POS | PLAYER | TEAM/OPP | SALARY |
| Captain | A.J. Brown, WR | Eagles @ NY | $14,700 |
| FLEX | Jalen Hurts, QB | Eagles @ NY | $11,000 |
| FLEX | Cam Skattebo, RB | Giants vs. PHI | $10,000 |
| FLEX | Dallas Goedert, TE | Eagles @ NY | $6,400 |
| FLEX | Theo Johnson, TE | Giants vs. PHI | $5,800 |
| FLEX | Devin Singletary, RB | Giants vs. PHI | $2,000 |
FanDuel TNF Week 6 Single-Game Optimal NFL DFS Lineup
| POS | PLAYER | TEAM/OPP | SALARY |
| MVP | Jalen Hurts, QB | Eagles @ NY | $20,400 |
| FLEX | Saquon Barkley, RB | Eagles @ NY | $13,000 |
| FLEX | Cam Skattebo, RB | Giants vs. PHI | $11,000 |
| FLEX | Dallas Goedert, TE | Eagles @ NY | $8,000 |
| FLEX | Theo Johnson, TE | Giants vs. PHI | $5,200 |
| FLEX | Beaux Collins, WR | Giants vs. PHI | $1,800 |