There are two teams on bye in Week 6, which means there are going to be 14 games from Sunday to Monday, with Thursday Night Football in the rear view. Below, we have NFL picks against the spread for each matchup.
NFL ATS Picks
Register on DraftKings, BetMGM, FanDuel and other sportsbook apps to make these wagers with NFL betting bonuses. In addition to against the spread picks, you’ll find markets for a variety of passing, rushing and receiving props.
Broncos vs. Jets
This is the overseas game being played in London this week. The Jets have looked dreadful and are the only team left this season without a win, but it would not be a surprise to see the Broncos come out a little slow in this one. They are coming off an impressive victory against the Eagles in Philadelphia last week and now must travel across the pond to London. It might take garbage time, but the Jets cover here.
Pick: Jets +7.5 (-115) BetMGM
Rams vs. Ravens
This is a tough one, as both teams need positive momentum this week. The Rams are coming off two brutal losses in a row, while the Ravens are still without Lamar Jackson, 1-4, and just got trounced two weeks in a row by the Chiefs and Texans. Do not feel great about this one, but the guess is here is the Ravens show some fight in this one.
Pick: Ravens +7.5 (-110) BetMGM
Cowboys vs. Panthers
The Panthers are 2-0 at home this year, and 0-3 on the road. For whatever reason, they seem to play much better at home, which has been the case over the past couple years even as they have struggled as a team. The Cowboys offense has been fantastic, but their defense has been anything but. The Panthers would not be a surprising home-dog to win outright.
Pick: Panthers +3 (+100) DraftKings
Cardinals vs. Colts
This Cardinals team looks dead in the water, especially now with Kyler Murray missing practice and possibly missing this week. The Colts just blew out the Raiders last week, and get another blowout victory this week.
Pick: Colts -7 (-118) BetMGM
Seahawks vs. Jaguars
This game is essentially a pick'em, with the spread ranging from Seahawks +1.5 to Seahawks -1.5. The Jaguars are 4-1, but have lived off turnovers, which is hard to replicate. The Seahawks get the job done here after a tough loss to Tampa Bay last week.
Pick: Seahawks Moneyline (-104) FanDuel
Chargers vs. Dolphins
After an impressive 3-0 start, the Chargers have now lost two in a row and are dealing with major injuries on both sides of the ball, especially their offensive line. Even though the Dolphins have not looked great this year, they are showing some fight, and OL injuries are always a team’s death sentence. This game stays within a field goal.
Pick: Dolphins +4.5 (-112) DraftKings
Patriots vs. Saints
The Patriots are coming off an impressive, emotional victory over the Bills in Buffalo last week, and now must travel to New Orleans to take on a Saints team coming off their first win of the season. This screams let-down spot for the Patriots.
Pick: Saints +3.5 (-110) Fanatics Sportsbook
Browns vs. Steelers
The Steelers are getting healthy on defense and coming off their bye week against a rookie QB making a road start. Hard to trust Dillon Gabriel and the Browns here.
Pick: Steelers -5.5 (-110) BetMGM
Titans vs. Raiders
The Titans just got their first win of the season but needed about three miraculous plays to go their way to win off a last-second field goal. The Raiders certainly have not looked great either as Geno Smith has been a turnover machine, but luckily the Titans run defense is among the worst in the NFL, so the Raiders can just lean on Jeanty here.
Pick: Raiders -3.5 (-115) ESPN BET
Bengals vs. Packers
Interesting game here, as the Packers are coming off a bye week after losing to the Browns three weeks ago and allowing 40 points in a tie to the Cowboys two weeks ago. Now, they face a broken Bengals team who has been blown out in each of the three weeks since QB Joe Burrow went down but now have Joe Flacco making his start for the team after trading for him. Flacco did manage to beat the Packers when he was a member of the Browns. Bengals keep this one within two touchdowns.
Pick: Bengals +14.5 (-115) FanDuel
49ers vs. Buccaneers
Both teams are 4-1 but probably do not deserve to have that record, at least based on point differential. The 49ers are a +8 and the Buccaneers are a +3. With the 49ers still dealing with a ton of injuries, the Bucs get the job done at home here.
Pick: Buccaneers -3 (-105) FanDuel
Lions vs. Chiefs
We have a great SNF game this week, with the Chiefs as slight home-favorites. The Chiefs lost last week but look to have figured out a lot of stuff after their 0-2 start, especially on offense. The Lions, meanwhile, have looked dominant after a bad Week 1 loss to the Packers. Tough game to predict, so we'll take the points with the underdog and hope it stays close.
Pick: Lions +2.5 (-110) Caesars Sportsbook
Bills vs. Falcons
The first of two Monday Night Football games features a Bills team coming off their first loss of the year, and a Falcons team fresh off a bye week. It has been hit-or-miss with QB Michael Penix this year, but the Bills run defense has been somewhat leaky, so this could be a big Bijan Robinson game. Falcons keep this one somewhat close at home.
Pick: Falcons +4.5 (-105) DraftKings
Bears vs. Commanders
This game features a lot of storylines, as it is a matchup between the No. 1 and No. 2 picks in the 2024 draft, and a rematch of the famous Hail Mary game last year, a Commanders miraculous victory. The Commanders got Jayden Daniel back last week and, unsurprisingly, got back on track with a victory against the Chargers. They get the job done Monday night.
Pick: Commanders -4.5 (-108) FanDuel