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Michigan vs. USC Picks: How to Bet Saturday Night Prime Time CFB

Alex Payton

Michigan vs. USC Picks: How to Bet Saturday Night Prime Time CFB image

© Gary A. Vasquez-Imagn Images

Today's college football action features a matchup of two of the sport's classic blueblood programs, and fans can get a detailed breakdown, including the best Michigan vs. USC betting pick for this high-stakes showdown.

 
  •  USC's explosive offense, averaging 48.4 points per game, clashes with Michigan's stout defense that allows just 16.2 points per contest.
  • The betting line has seen a significant four-point swing, moving from Michigan (-1.5) at open to USC (-2.5), indicating strong market confidence in the Trojans at home.
  • Key player props to watch include USC quarterback Jayden Maiava's passing yards (266.5) against a tough secondary and Michigan running back Justice Haynes' rushing total (105.5) against an underrated Trojan run defense.

A marquee Big Ten showdown with potential College Football Playoff implications is set for Los Angeles as two titans clash in a classic offense vs. defense battle. The USC Trojans bring their high-octane air raid attack, led by quarterback Jayden Maiava, into a head-on collision with the Wolverines' punishing, ground-and-pound identity. Maiava has been surgical this season, completing 70.5% of his passes while orchestrating an offense that churns out a staggering 338 passing yards per game with a stellar 11-to-1 touchdown-to-interception ratio.

On the other sideline, the Michigan Wolverines prefer to dictate the terms of engagement through brute force. Quarterback Bryce Underwood has been an effective game manager, completing 59.2% of his passes, but his primary role is to hand the ball off and let the offensive line and stable of running backs bulldoze through opposing defenses.

This NCAAF matchup presents a fascinating schematic chess match: can USC’s offense score enough to force Michigan out of its comfort zone, or will the Wolverines’ defense and clock-controlling run game suffocate the Trojans at home? This preview will break down the odds, key matchups, and player props to provide the best betting angles for this pivotal Week 7 contest.

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Best Michigan vs. USC Betting Picks

The Wolverines (5-0) travel to face the Trojans (5-0) at the historic Los Angeles Memorial Coliseum in Los Angeles, CA. This Big Ten conference battle is scheduled for kickoff at 4:30 PM PDT, and the game will be broadcast nationally on NBC. The weather forecast calls for a perfect afternoon for football, with clear skies and temperatures in the low 70s with minimal wind, ensuring conditions won't hinder either team's game plan.

Michigan vs. USC Betting Odds

Bet TypeMichigan WolverinesUSC Trojans
Spread+2.5 (-108)-2.5 (-112)
Moneyline+114-135
Total PointsOver 57.5 (-111)Under 57.5 (-109)

The odds paint the Trojans as slight home favorites, with their (-135) moneyline price implying a 57.5% probability of victory. After removing the vigorish, the market projects USC's true win probability at approximately 55.2%, with the Wolverines holding a 44.8% chance.

Both teams enter this contest with a 2-3 record against the spread (ATS) this season, making this a difficult matchup to handicap from a trend perspective. The high total of 57.5 reflects the market's respect for USC's explosive offense, which averages over 48 points per game.

Michigan vs. USC Odds Movement & Analysis

This betting line has experienced a significant shift since opening. Oddsmakers initially installed Michigan as 1.5-point road favorites, but the market has swung a full four points in favor of the Trojans, who now sit as 2.5-point favorites. This dramatic movement suggests that early and heavy money, likely from sharp bettors, has backed USC at home.

The total has also seen a substantial jump, climbing from an opening of 53.5 to its current perch at 57.5. This upward trend indicates that bettors are anticipating a high-scoring affair, driven by USC's quick-strike offense and the potential for Michigan to be drawn into a shootout.

The line movement creates a fascinating dynamic for bettors. Those who backed USC early got tremendous value, while the current line at (-2.5) still keeps the key number of three in play. The public appears to be slightly favoring Michigan to cover the spread, creating a classic sharp vs. public divide. The value may now lie in taking the under, as the total has been inflated by four points from its opening number, potentially overcorrecting for USC's offensive prowess against a top-tier Michigan defense.

Michigan vs. USC – Key Matchups to Watch

Quarterback vs Pass Defense

This is the game's central conflict. USC's Maiava operates an offense averaging a blistering 317.4 passing yards per game with a 191.1 QB rating. He's protected by an offensive line that has surrendered only four sacks all year. He faces a Michigan secondary that allows a respectable 206.4 passing yards per game and has generated seven interceptions. The Wolverines' pass rush has been effective, tallying 15 sacks, and their ability to generate pressure without blitzing will be critical to disrupting Maiava's rhythm.

Running Game vs Run Defense

Michigan's identity is its ground-and-pound attack, which racks up 240.4 rushing yards per game behind a powerful offensive line. Running back Justice Haynes is the bell cow, and his ability to control the clock is Michigan's best defense against USC's offense. They'll be running into a surprisingly stout USC run defense that yields just 108.4 yards per game and 3.5 yards per carry. If the Trojans can win on early downs and force Michigan into obvious passing situations, it will fundamentally alter the game.

Pass Catchers vs Secondary

USC receiver Makai Lemon (82.5 receiving yards prop) headlines a deep and talented group that excels at creating separation. They will be tested by a physical Michigan secondary that thrives on tight coverage and contested catches. For Michigan, Donaven McCulley (51.5 receiving yards prop) is the primary target for Bryce Underwood. They will look for favorable matchups against a USC secondary that can be susceptible to giving up big plays, allowing 251 passing yards per game.

Offensive Line vs Pass Rush

The battle in the trenches will be decisive. USC's offensive line has been elite in pass protection, allowing Maiava ample time in the pocket. They face their toughest test yet against a Michigan front that features multiple disruptive pass rushers. Conversely, Michigan's offensive line is built to create movement in the run game but has shown some vulnerability in pass protection. USC's defense has recorded 17 sacks and will need to generate consistent pressure to keep Underwood uncomfortable.

Michigan vs. USC Player Props: Passing

Maiava's passing yards prop of 266.5 is significantly below his team's season average of 317.4, a nod to the strength of Michigan's defense. However, given USC's offensive scheme and pace, he could easily surpass this number even in an efficient performance.

Underwood's line is set at a modest 186.5 yards, reflecting Michigan's run-first approach. If USC jumps out to an early lead, Underwood will be forced to throw more than usual, potentially pushing him over this total.

Rushing & Receiving Props

PlayerRushing YardsReceiving YardsReceptionsAnytime TD
Justice Haynes (MICH)105.5 (O -115 | U -115)N/AN/AYes -260 | No +192
Waymond Jordan (USC)72.5 (O -115 | U -114)N/AN/AYes -180 | No +288
Makai Lemon (USC)N/A82.5 (O -115 | U -115)N/AYes -126 | No +463
Donaven McCulley (MICH)N/A51.5 (O -114 | U -115)N/AYes +292 | No +2750

Haynes is expected to carry a heavy workload, and his 105.5 rushing yards prop reflects that. He faces a tough USC run defense, making the under a tempting play. For USC, lead receiver Lemon's line is set at 82.5 yards. Against a formidable Michigan secondary, he'll need to win his one-on-one matchups to hit the over. His Anytime TD prop at -126 offers value, as he is Maiava's most trusted target in the red zone.

Michigan vs. USC Picks & Prediction

 

This matchup boils down to whether the USC Trojans' elite offense can impose its will on the Michigan Wolverines' elite defense. The four-point line move in USC's favor is a massive indicator that the market believes the Trojans' offensive firepower and home-field advantage will be the difference.

USC's offense is not just productive, averaging 8.5 yards per play, but also incredibly efficient, converting on 56% of their third downs and scoring on 96% of their red zone trips. Jayden Maiava is protected by a phenomenal offensive line that should be able to neutralize Michigan's pass rush just enough to allow him to find his playmakers in space.

While Michigan's strategy to control the clock with a rushing attack is sound, they may not have the offensive firepower to keep pace if they fall behind. The Wolverines average a modest 200.6 passing yards per game, and their offense can become one-dimensional against a defense that doesn't have to respect the deep ball.

USC's run defense is statistically strong, allowing only 3.5 yards per carry, which could be enough to get Michigan off schedule. The Trojans thrive in high-possession games, and even a dominant Michigan rushing performance might not be enough to keep the ball away from USC's offense. In what should be a highly entertaining contest, I'm backing the team with the more explosive and multiple offense playing in their home stadium.

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Picks:

  • USC -2.5 (-112)
  • Over 57.5 (-111)
  • Player Prop: Jayden Maiava Over 266.5 Passing Yards (-115)

Public Betting Splits

Early betting data indicates a slight lean from the public on the Michigan Wolverines to cover the +2.5 spread. However, the significant line movement from Michigan (-1.5) to USC (-2.5) suggests that the larger, sharper bets have come in on the Trojans. This classic "sharps vs. public" disagreement often points to value on the side the professional bettors are backing.

Recent History: Michigan Wolverines vs. USC Trojans

These two programs met last season in 2024, with the Wolverines securing a tight 27-24 comeback victory. That game was a hard-fought, physical affair, but both teams have evolved since then. The Trojans will undoubtedly be looking for revenge on their home turf in this new chapter of their Big Ten rivalry.

Alex Payton

Alex Payton is a betting content producer for The Sporting News. A resident of Kentucky, Alex graduated from the University of Louisville in 2017 and is a devoted Cardinals fan. He has several years of experience creating dedicated content for various publications in the online sports betting industry.