49ers vs. Rams Betting Promos: Get Top Thursday Night Football Offers

An NFC West rivalry renews as the San Francisco 49ers travel to SoFi Stadium to take on the Los Angeles Rams. To get you ready for this pivotal matchup, top online sportsbooks are featuring some of the best new betting promos of the season.

Bettors looking to get in on the action can unlock up to six valuable new user welcome bonuses, which can be applied to this Thursday night clash or any other NFL game on the Week 5 slate. We've compiled and will break down the top offers available from leading sportsbooks to help you make the most of your NFL wagers.

49ers vs. Rams Betting Promos for Thursday Night Football

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bet365 Bonus Code TSN365: Claim Your Choice of NFL Offer

Known globally for its extensive betting markets, bet365 gives new users a unique and flexible welcome offer. By using the bonus code TSN365 at sign-up, you get to decide which promotion best suits your betting style for all the upcoming NFL action.

You can choose between two distinct but equally valuable offers:

• Bet $5, Win a $200 Guaranteed Bonus: This is the ideal path for bettors who want to start with a guaranteed win. Simply place your first wager of at least $5, and bet365 will credit your account with $200 in bonus bets, regardless of your initial bet's outcome. It's a fantastic, low-risk way to build your betting bankroll from a small starting stake.
• $1,000 First Bet Safety Net: For those who want to make a larger opening play, this offer acts as a valuable insurance policy. Place your first real-money bet up to $1,000. If it loses, bet365 refunds your entire stake in the form of bonus bets. This allows you to take a confident swing on your first wager, knowing you have a second chance in your back pocket.

Whether you want the security of a guaranteed $200 bonus or the high-stakes protection of the $1,000 Safety Net, remember to use code TSN365 to unlock your choice at bet365.

BetMGM Bonus Code TSN1500: Claim $1,500 First Bet

BetMGM, "The King of Sportsbooks," provides new users with a royal welcome, offering two distinct and valuable promotions depending on your location.

For bettors in most states, the bonus code TSN1500 unlocks a massive $1,500 first bet offer. This is an ideal promotion for those looking to make a significant first wager on an NFL game. Place your first bet, and if it loses, BetMGM will credit your account back with bonus bets equal to your original stake, up to $1,500. This incredible offer allows you to take a big swing with your first pick, knowing you have a safety net in place.

For users signing up in Michigan, New Jersey, Pennsylvania, or West Virginia, a different bonus is available with the code TSN150. This promotion is perfect for building a bankroll with a small initial investment.

• Register a new account with code TSN150
• Place a first wager of at least $10 on any market
• If your bet wins, you will receive $150 in bonus bets

San Francisco 49ers vs. Los Angeles Rams Odds

Odds as of October 2, 2025, from MGM.

The betting lines for this NFC West clash tell a story of complete dominance by the home team. The Los Angeles Rams are massive -455 favorites, a line that has moved significantly from its -120 opening. The spread has also ballooned from an initial 1.5 points to a hefty 8.5 points in favor of the Rams.

The market's confidence in the Rams is backed by several powerful trends. Los Angeles has been nearly unbeatable at home as a favorite, going 8-1 straight-up in their last nine such contests. Furthermore, they have been an excellent bet against the spread, covering in four straight home games and going a perfect 4-0 ATS against the 49ers in their last four meetings.

For the 49ers, the trends are equally stark but in the opposite direction. They are currently on a seven-game losing streak as an underdog and have failed to cover the spread in their last six games when getting points. Their struggles are magnified on the road, where they are 0-4 ATS as an underdog over their last four games.

The total for this game has seen a notable drop from its opening of 47.5 down to 44.5. While the over has hit in four of the last five matchups between these two teams, a contradictory trend shows the under hitting in the last five Rams home games where they were the favorite. With the game being played indoors at SoFi Stadium, weather will not be a factor in the scoring.

San Francisco 49ers vs. Los Angeles Rams Anytime Touchdown Scorer Props

Anytime touchdown scorer props are among the most popular bets for any NFL game, and this rivalry matchup is loaded with offensive talent. The odds indicate that oddsmakers expect the primary playmakers for both teams to find the end zone. Rams running back Kyren Williams leads all players as the most likely to score with odds of -205, closely followed by 49ers star Christian McCaffrey (-123) and Rams receiver Puka Nacua (-106).

These three are the only players with negative odds to score, highlighting their critical roles. Davante Adams, another key target for the Rams, sits just on the plus-money side at +102. For those looking for a bit more value on the 49ers' side, receiver Kendrick Bourne presents an intriguing option at +305.

Here are the consensus odds for some of the top players to score a touchdown at any point during the game:

Odds from consensus market data as of Oct. 2, 2025.